In User: Drkrishnasarmapathy

4450?size=160x160

Name: Drkrishnasarmapathy

Joined: Tuesday 24 July 2012 08:13:50 (UTC)

Last seen: Wednesday 11 May 2022 06:13:28 (UTC)

Email (public): drkrishnasarmapathy

Website: http://www.linkedin.com/profile/view?id=59539573&trk=tab_pro

Location: lucknow, India

Drkrishnasarmapathy has been credited 67 times

Drkrishnasarmapathy has an average rating of:

0.0 / 5

(0 ratings in total)

for their items

To carry out  Quality assurance  and development activity in the field of Organic Chemistry, to make profit for the organization, motivate, guide & lead a team of scientists, Direct strategic planning and the development of goals allied with organization objectives for the Quality group. Ensure the development of talent for leadership roles and plan talent succession for Quality Specialty Operations. Key focuses on maintaining State Of Control, Quality, Compliance, robust and efficient service level and continues improvement.Recommend actions or policies that result in quality operational sites enhancements for compliance and inspection readiness, ensure that critical or strategic priorities at the regional sites are adhering to global quality policies and that sufficient quality oversight is demonstrated in all operational deliverables. Acting as Quality Program Lead for assigning projects to ensure appropriate quality of development and production within defined timelines. Representing Quality Operations in cross-functional project teams with responsibility for oversight of the overall quality of the project .Co-ordinate with inter department functions and manufacturing site functions for technical evaluations and review wherever required.
Assure the cross regional systems implementations are integrated and provide the highest level of efficiency. This includes Laboratory Process optimization, Operational Excellence, analytical excellence, compliance level setting and Global Strategic IT implementations (LIMS, TrackWise, Documentum and other GMP system etc.). Up date knowledge and understanding of worldwide requirements of cGMP and Quality Systems for Commercial products.Hands-on expertise in highest quality standards, GMP compliance and build a quality orientated culture.and worked in regulated plants having approvals of US FDA, MHRA.etc.Hands-on experience in successfully handling and implementing cGMP (Current Good Manufacturing Practice) practices, quality management system, risk assessment, mitigation and Good Documentation Practices


Other contact details:

researchgate
scribd

Interests:

: To carry out research and development activity in the field of Organic Chemistry, to make profit for the organization, motivate, guide & lead a team of scientists, conduct literature search, identify and execute new/novel routes for the synthesis, scale up from grams to kilo levels in lab., conduct pilot trials and assist in production upto ton levels. Carry out impurity profiles and assist in dossier writing. All the above being done keeping in mind the regulatory, safety, environmental issues. To keep in mind IPR issues and draft patents , Commercial aspects taken care are the time schedules, quality parameters and cost factors. All this with a view of non infringement and confidentiality. Simultaneously develop business acumen and convert to profits.file DMFS in US and EU, file patents and contribute to intellectual property

Field/Industry: CHEMICAL/PHARMA

Occupation/Role(s): HEAD

Organisation(s):

IPL LTD

 

Note: some items may not be visible to you, due to viewing permissions.

File

Uploader

Blob Antiviral Drugs in the battle against COVID-19 & Min...

Created: 2022-02-02 07:17:26

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Patent Evaluation of Antiviral Drugs in the battle against COVID-19 &Minimization of Risks Associated with Occurrence of Dangerousviral mutations During Treatment with Antiviral Mutagenic Agents 

File type: Adobe PDF

Comments: 0 | Viewed: 29 times | Downloaded: 2 times

Tags:

File

Uploader

Blob International Journal of Research Studies in Medical...

Created: 2020-08-21 11:22:57

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Abstract – Hydroquinone as a volatile aromatic hydrocarbon; There is a huge confusion in the public, as well as among politicians and even some scientists, about those two molecules. That confusion ultimately led to people accidently overdosing. Both molecules can be classified as 4-aminoquinolines, and both have anti-plasmodial activities, but they remain two different molecules with some different metabolites. Chloroquine has been widely used since the 1950s for prophylactic and ...

File type: Adobe PDF

Comments: 0 | Viewed: 45 times | Downloaded: 2 times

Tags:

File

Uploader

Blob Antiviral nucleosides- Flu Viruses- QUINOLINES-COV...

Created: 2020-08-21 10:58:20 | Last updated: 2020-08-21 10:58:52

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Antiviral nucleosides-  Flu Viruses-                QUINOLINES-COVID-19 Hydroquinone as a volatile aromatic hydrocarbon; There is a huge confusion in the public, as well as among politicians and even some scientists, about those two molecules. That confusion ultimately led to people accidently overdosing. Both molecules can be classified as 4-aminoquinolines, and both have anti-plasmodial activities, but they...

File type: Adobe PDF

Comments: 0 | Viewed: 40 times | Downloaded: 2 times

This File has no tags!

File

Uploader

Blob HCV NS3/4A 3 Protease Inhibitors: Simeprevir, Proces...

Created: 2020-02-19 06:12:03

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

In polymerase and protease drug targets and drug development, which has resulted in a strong infectious disease R&D portfolio,”and has given the company its key pipeline asset, simeprevir (TMC435), a novel protease inhibitor in Phase III clinicaldevelopment for hepatitis C that is being developed in collaboration with Janssen Pharmaceuticals. Currently, hepatitis C virus(HCV) infection is considered a serious health-care problem all over the world. A good number of direct-acting ant...

File type: Adobe PDF

Comments: 0 | Viewed: 7 times | Downloaded: 1 time

This File has no tags!

File

Uploader

Blob Chronic Hepatitis (Chc), Viral Polymerase Nucleotide...

Created: 2019-10-12 11:22:31

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Sofosbuvir is a viral polymerase nucleotide inhibitor that was approved in December2013 by the United States Food and Drug Administration (FDA), and in January 2014by the European Medicines Agency for the treatment of HCV infection [1]. The WHOGuidelines for the screening, care and treatment of persons with hepatitis C infectionrecommend sofosbuvir in combination with ribavirin in genotypes 1, 2, 3 and 4 HCVinfection, either with or without pegylated interferon (depending on the HCV genotype)...

File type: Adobe PDF

Comments: 0 | Viewed: 11 times | Downloaded: 1 time

This File has no tags!

File

Uploader

Blob Bempedoic Acid a Small Molecule Drug Process and Syn...

Created: 2019-07-23 07:04:13

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Low Density Lipoprotein Cholesterol AbstractBempedoic acid (ETC-1002), a small molecule drug, promotes low density lipoprotein (LDL) receptor mediated clearanceof LDL-cholesterol (LDL-C) by inhibition of adenosine triphosphate citrate lyase (ACL), a mechanism complementary to thoseof existing lipid-modifying therapies. Bempedoic acid is a pro-drug activated specifically within the liver where it inhibits ACL,a regulatory checkpoint within the cholesterol biosynthesis pathway. By inhibiti...

File type: Adobe PDF

Comments: 0 | Viewed: 14 times | Downloaded: 2 times

This File has no tags!

File

Uploader

Blob Crystallization and Polymorphism-Scalable Process fo...

Created: 2018-12-04 11:45:47

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Crystallization and Polymorphism-Scalable Process for Celecoxib and It’s Polymorph From-3

File type: Adobe PDF

Comments: 0 | Viewed: 12 times | Downloaded: 1 time

This File has no tags!

File

Uploader

Blob Citation: Krishnasarma P, MS Chakravarthy. Crystalli...

Created: 2018-12-04 11:43:44

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Citation: Krishnasarma P, MS Chakravarthy. Crystallization and Polymorphism-Scalable Process for Celecoxib and It’s Polymorph From-3(Non- Steroidal Anti-Inflammatory Drug (NSAID). LOJ Med Sci 2(2)-2018. LOJMS.MS.ID.000134. 125Review ArticleCrystallization and Polymorphism-Scalable Process forCelecoxib and It’s Polymorph From-3 (Non- SteroidalAnti-Inflammatory Drug (NSAID) 

File type: Adobe PDF

Comments: 0 | Viewed: 22 times | Downloaded: 3 times

This File has no tags!

File

Uploader

Blob Cefpodoxime Proxetil and its By-Products: A Comparat...

Created: 2018-08-31 07:40:48

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Cefpodoxime Proxetil and its By-Products: A Comparative Study as Per EP-7 Krishnasarma pathy*LOJ Med Sci 

File type: Adobe PDF

Comments: 0 | Viewed: 2 times | Downloaded: 2 times

Tags:

File

Uploader

Blob Biomedical Journal of Scientific & Technical Research.

Created: 2018-08-31 06:24:53

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Considerations for Successful Scale-Up to Tox Batches and Phase-Api (Bulk Drug substance)[*]       Krishnasarma pathy* DOI : 10.26717/BJSTR.2018.08.001662Biomedical Journal of Scientific & Technical Research.

File type: Adobe PDF

Comments: 0 | Viewed: 7 times | Downloaded: 1 time

This File has no tags!

File

Uploader

Blob Biomedical Journal of Scientific & Technical Researc...

Created: 2018-08-31 06:23:50

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Considerations for Successful Scale-Up to Tox Batches and Phase-Api (Bulk Drug substance)[*]       Krishnasarma pathy* DOI : 10.26717/BJSTR.2018.08.001662Biomedical Journal of Scientific & Technical Research.

File type: Adobe PDF

Comments: 0 | Viewed: 1 time | Downloaded: 1 time

This File has no tags!

File

Uploader

Blob Case History-The Control of Impurities-A Critical Is...

Created: 2018-08-01 05:40:18

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Case History-The Control of Impurities-A CriticalIssue to The Active Pharmaceutical Ingredient 

File type: Adobe PDF

Comments: 0 | Viewed: 2 times | Downloaded: 2 times

Tags:

File

Uploader

Blob Case History-The Control of Impurities-A Critical Is...

Created: 2018-08-01 05:35:55

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Case History-The Control of Impurities-A CriticalIssue to The Active Pharmaceutical Ingredient 

File type: Adobe PDF

Comments: 0 | Viewed: 1 time | Downloaded: 2 times

Tags:

File

Uploader

Blob Herald Scholarly Open Access Pathy K (2018) Entecavi...

Created: 2018-07-28 07:03:39

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Herald Scholarly Open Access  krishnasarma Pathy K (2018) Entecavir Patent Evaluation & Genotoxicity.pdf

File type: Adobe PDF

Comments: 0 | Viewed: 2 times | Downloaded: 2 times

Tags:

File

Uploader

Blob Herald Scholarly Open Accesskrishnasarma Pathy K (20...

Created: 2018-07-28 07:01:30 | Last updated: 2018-07-28 07:01:52

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Herald Scholarly Open Accesskrishnasarma Pathy K (2018) Entecavir Patent Evaluation & Genotoxicity.

File type: Adobe PDF

Comments: 0 | Viewed: 5 times | Downloaded: 1 time

Tags:

File

Uploader

Blob Krishnasarma Pathy (2018) Process for Preparation of...

Created: 2018-07-14 06:13:35

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Krishnasarma Pathy (2018) Process for Preparation of Vitamin C and Method for Determination of Vitamin C in Tablets. SF J Chem Res 2:1.

File type: Adobe PDF

Comments: 0 | Viewed: 1 time | Downloaded: 1 time

This File has no tags!

File

Uploader

Blob Method for Preparation of Vitamin C and Method for D...

Created: 2018-07-14 06:12:11

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Procedure for calcium ascorbate (VITAMIN-C) includes such technological steps as reaction of ascorbic acidon calcium carbonate in water in recent years; the determination of vitamin C has become an important subject in the fieldof biochemistry and commercial foods. This is because vitamin C plays an important role in maintaining human health.Due to the importance of vitamin C in human beings, the quantitative analysis of vitamin C has gained a significantincrease in several areas of analytica...

File type: Adobe PDF

Comments: 0 | Viewed: 1 time | Downloaded: 1 time

This File has no tags!

File

Uploader

Blob Entecavir Patent Evaluation, Method for Diastereomer...

Created: 2018-06-29 10:47:08 | Last updated: 2018-06-29 10:48:15

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Entecavir Patent Evaluation, Method for Diastereomeric ImpuritiesEntecavir is an oral antiviral drug used in the treatment of hepatitis B infection. Entecavir is a guanosine nucleoside analogue with selective activity against hepatitis B virus (HBV), which inhibits reverse transcription, The initial patent on entecavir expired in South Africa in 2011 ZA 1991/07894. Current status available on: http://patentsearch.cipc.co.za/, which should have permitted lower-cost generic competitors to enter...

File type: Adobe PDF

Comments: 0 | Viewed: 3 times | Downloaded: 2 times

This File has no tags!

File

Uploader

Blob Organic and Medicinal Chemistry International Journa...

Created: 2018-06-29 10:43:43

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Organic and Medicinal Chemistry International Journal:Entecavir Patent Evaluation, Method for Diastereomeric ImpuritiesEntecavir is an oral antiviral drug used in the treatment of hepatitis B infection. Entecavir is a guanosine nucleoside analogue with selective activity against hepatitis B virus (HBV), which inhibits reverse transcription, The initial patent on entecavir expired in South Africa in 2011 ZA 1991/07894. Current status available on: http://patentsearch.cipc.co.za/, which should ...

File type: Adobe PDF

Comments: 0 | Viewed: 3 times | Downloaded: 1 time

This File has no tags!

File

Uploader

Blob krishnasarmapathy-Entecavir Patent Evaluation, Molec...

Created: 2018-06-21 05:38:08

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Entecavir is an oral antiviral drug used in the treatment of hepatitis B infection. Entecavir is a guanosine nucleoside analogue with selective activity against hepatitis B virus (HBV), which inhibits reverse transcription, Hepatitis B virus (HBV) is highly endemic in South Africa and across sub-Saharan Africa, where around 8% of people are chronically infected, and rates of HBV-related liver cancer are some of the highest in the world. Globally, viral hepatitis causes approximately 1.3 milli...

File type: Adobe PDF

Comments: 0 | Viewed: 4 times | Downloaded: 1 time

Tags:

File

Uploader

Blob Entecavir Patent Evaluation, Molecular Modelling Stu...

Created: 2018-06-21 05:36:07

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Entecavir is an oral antiviral drug used in the treatment of hepatitis B infection. Entecavir is a guanosine nucleoside analogue with selective activity against hepatitis B virus (HBV), which inhibits reverse transcription, Hepatitis B virus (HBV) is highly endemic in South Africa and across sub-Saharan Africa, where around 8% of people are chronically infected, and rates of HBV-related liver cancer are some of the highest in the world. Globally, viral hepatitis causes approximately 1.3 milli...

File type: Adobe PDF

Comments: 0 | Viewed: 3 times | Downloaded: 1 time

This File has no tags!

File

Uploader

Blob Process for Preparation of Vitamin C and Method for ...

Created: 2018-06-19 06:44:55

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Process for Preparation of Vitamin C and Method for Determination of Vitamin C in Tablets

File type: Adobe PDF

Comments: 0 | Viewed: 2 times | Downloaded: 1 time

This File has no tags!

File

Uploader

Blob Process for Preparation of Vitamin C and Method for ...

Created: 2018-06-19 06:43:19 | Last updated: 2018-06-19 06:43:37

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Process for Preparation of Vitamin C and Method for Determination of Vitamin C in Tablets

File type: Adobe PDF

Comments: 0 | Viewed: 3 times | Downloaded: 1 time

This File has no tags!

File

Uploader

Blob SCHOLARLY JOURNAL OF FOOD AND NUTRITION-Route Evalua...

Created: 2018-06-04 05:32:46 | Last updated: 2018-06-04 05:34:44

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

This is out line work on the process development for the synthesis of buprenorphine, naltrexone, naloxone, and nalbuphine from naturally occurring opiates such as Thebaine, also known as codeine methyl enol ether, and oripavine. Several new methods for N-demethylation of morphinans have been developed during the pursuit of this research. The article traces the evolution of various approaches and provides a comparison for overall efficiency. A reverse phase high performance liquid chromatograp...

File type: Adobe PDF

Comments: 0 | Viewed: 6 times | Downloaded: 1 time

This File has no tags!

File

Uploader

Blob Route Evaluation and Analytical HPLC Method Developm...

Created: 2018-06-04 05:30:06 | Last updated: 2018-06-04 05:30:26

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

This is out line work on the process development for the synthesis of buprenorphine, naltrexone, naloxone, and nalbuphine from naturally occurring opiates such as Thebaine, also known as codeine methyl enol ether, and oripavine. Several new methods for N-demethylation of morphinans have been developed during the pursuit of this research. The article traces the evolution of various approaches and provides a comparison for overall efficiency. A reverse phase high performance liquid chromatograp...

File type: Adobe PDF

Comments: 0 | Viewed: 5 times | Downloaded: 1 time

This File has no tags!

File

Uploader

Blob process development of antiviral agents : Amantadin...

Created: 2018-05-05 07:09:19

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Recent advances in process development of antiviral agents targeting the influenza virus: Amantadine-Remantadine-derived pharmaceutical agents"

File type: Adobe PDF

Comments: 0 | Viewed: 6 times | Downloaded: 3 times

This File has no tags!

File

Uploader

Blob Recent advances in process development of antiviral ...

Created: 2018-05-05 07:08:14

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Recent advances in process development of antiviral agents targeting the influenza virus: Amantadine-Remantadine-derived pharmaceutical agents"

File type: Adobe PDF

Comments: 0 | Viewed: 5 times | Downloaded: 3 times

This File has no tags!

File

Uploader

Blob IJMSCI Recent advances in process development of ant...

Created: 2018-05-05 07:07:31

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Recent advances in process development of antiviral agents targeting the influenza virus: Amantadine-Remantadine-derived pharmaceutical agents"

File type: Adobe PDF

Comments: 0 | Viewed: 5 times | Downloaded: 1 time

This File has no tags!

File

Uploader

Blob Bigunidine Metformin Pharmacologically Efficacious T...

Created: 2018-03-23 07:50:58

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Metformin usage may be considered for people with type 2 diabetes to help them control their blood sugar levels a secondary sideeffect may be weight loss, which leads some to believe it may be a viable medication to use for weight loss. However, researchers arestill not clear on whether or not metformin has an actual impact on weight, or if weight loss is due to lifestyle changes in people withtype 2 diabetes. Metformin (Glucophage, Glumetza, Fortamet) is typically prescribed to counteract th...

File type: PNG image

Comments: 0 | Viewed: 13 times | Downloaded: 5 times

This File has no tags!

File

Uploader

Blob Bigunidine Metformin Pharmacologically Efficacious T...

Created: 2018-03-23 07:49:08

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Metformin usage may be considered for people with type 2 diabetes to help them control their blood sugar levels a secondary sideeffect may be weight loss, which leads some to believe it may be a viable medication to use for weight loss. However, researchers arestill not clear on whether or not metformin has an actual impact on weight, or if weight loss is due to lifestyle changes in people withtype 2 diabetes. Metformin (Glucophage, Glumetza, Fortamet) is typically prescribed to counteract th...

File type: XML

Comments: 0 | Viewed: 17 times | Downloaded: 5 times

This File has no tags!

File

Uploader

Blob Synthesis of Sildenafil Citrate Validated HPLC Metho...

Created: 2018-03-23 07:47:52

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

The present study describes analytical method of 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H–pyrazolo[4,3-d]pyrimidin-5-yl)-4- ethoxyphenyl]sulphonyl]-4methypiperazine citrate (sildenafil Citrate). The following specification particularly describes and ascertains the nature of this invention, and the manner in which it is to be performed. Sildenafil is an oral drug used primarily to treat male sexual function problems (impotence or erectile dysfunction) since becoming available in 199...

File type: Adobe PDF

Comments: 0 | Viewed: 7 times | Downloaded: 1 time

This File has no tags!

File

Uploader

Blob Synthesis of Sildenafil Citrate Validated HPLC Metho...

Created: 2018-03-23 07:46:48

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

The present study describes analytical method of 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H–pyrazolo[4,3-d]pyrimidin-5-yl)-4- ethoxyphenyl]sulphonyl]-4methypiperazine citrate (sildenafil Citrate). The following specification particularly describes and ascertains the nature of this invention, and the manner in which it is to be performed. Sildenafil is an oral drug used primarily to treat male sexual function problems (impotence or erectile dysfunction) since becoming available in 199...

File type: XML

Comments: 0 | Viewed: 12 times | Downloaded: 3 times

This File has no tags!

File

Uploader

Blob Antihistamine Drugs Possess some Antiacetylcholine P...

Created: 2018-03-10 06:27:28

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Antihistamine Drugs Possess someAntiacetylcholine Properties 

File type: Adobe PDF

Comments: 0 | Viewed: 7 times | Downloaded: 3 times

This File has no tags!

File

Uploader

Blob Epidemic Flu Viruses & the influenza a virus

Created: 2018-03-10 06:26:15

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Epidemic Flu Viruses & the influenza a virus

File type: JPEG image

Comments: 0 | Viewed: 7 times | Downloaded: 3 times

This File has no tags!

File

Uploader

Blob Nutri Food Sci Int J 5(5): NFSIJ.MS.ID.555674 (2018)...

Created: 2018-03-10 06:24:50

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Nutri Food Sci Int J 5(5): NFSIJ.MS.ID.555674 (2018) 001

File type: JPEG image

Comments: 0 | Viewed: 6 times | Downloaded: 3 times

This File has no tags!

File

Uploader

Blob Krishnasarma Pathy* DOI: 10.19080/OAJT.2018.02.55559...

Created: 2018-03-09 08:06:21

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Epidemic Flu Viruses & the influenza a virus subtypes H1N1, H1N2 and H3N2, HDFxKrishnasarma Pathy*Head of QC/QA, IPL Research Centre, IndiaSubmission: October 31, 2017; Published: March 07, 2018*Corresponding author: Krishnasarma Pathy, Head of QC/QA, IPL Research Centre, India, Tel: 9919188895,Email:Open Acc J of Toxicol. 2018; 2(4): OAJT.MS.ID.555593 (2018)001Mini ReviewThe history of flu viruses teaches that the influence has origin from animal’s birds, generically aquatic, and t...

File type: Adobe PDF

Comments: 0 | Viewed: 2 times | Downloaded: 2 times

This File has no tags!

File

Uploader

Blob Krishnasarma Pathy*Flu Viruses Open Acc J of Toxicol...

Created: 2018-03-09 08:04:06

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Krishnasarma Pathy*Head of QC/QA, IPL Research Centre, IndiaSubmission: October 24, 2017; Published: March 07, 2018*Corresponding author: Krishnasarma Pathy, Head of QC/QA, IPL Research Centre, India, Tel: 9919188895Human H1N1 pandemic developed from the originally localized Mexican source early in the spring 2009. For the emergency created by the epidemic of influence of the pigs in Mexico it was correct not to create alarmism being victims of bad information. Cytokine storm should be mentio...

File type: Adobe PDF

Comments: 0 | Viewed: 1 time | Downloaded: 1 time

This File has no tags!

File

Uploader

Blob Abstract Human H1N1 pandemic developed from the orig...

Created: 2018-03-08 10:54:10

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

For the emergency created by the epidemic of influence of the pigs in Mexico it was correct not to create alarmisms being victims of a bad information. The possibility that the virus arrives in other parts of the world is real as for all the types of influence virus. In order that a strain has a wide distribution, its antigenic characteristics must ensure that it escapes the neutralization of antibodies of the host and of the surrounding population. The discovery of a new, biologic Host-Defen...

File type: Adobe PDF

Comments: 0 | Viewed: 3 times | Downloaded: 1 time

This File has no tags!

File

Uploader

Blob FLUVIRUSES

Created: 2018-03-08 10:51:51 | Last updated: 2018-03-08 10:52:22

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

AbstractHuman H1N1 pandemic developed from the originally localized Mexican source early in the spring 2009. For the emergency created by the epidemic of influence of the pigs in Mexico it was correct not to create alarmism being victims of bad information. Cytokine storm should be mentioned as one of the key pathogenic events contributing to the overall mortality in substantial portion of patients. If active immunization is assumed to be preventive measure of proven efficacy, clinicians are ...

File type: Adobe PDF

Comments: 0 | Viewed: 1 time | Downloaded: 1 time

This File has no tags!

File

Uploader

Blob Title (-)-Galantamine Pharmacological screening and...

Created: 2018-01-27 07:48:18 | Last updated: 2018-01-27 07:48:42

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

No description

File type: Adobe PDF

Comments: 0 | Viewed: 3 times | Downloaded: 1 time

This File has no tags!

File

Uploader

Blob http://scifed.com/fulltext/the-influenza-a-virus-sub...

Created: 2017-12-28 05:55:47 | Last updated: 2017-12-28 05:55:56

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

http://scifed.com/fulltext/the-influenza-a-virus-subtypes-h1n1-h1n2-and-h3n2-hdfx-a-novel-immunomodulatorand-potential-fighter-against-cytokine-storms-in-viral-flu-infections-carica-papaya-linn/21844#one

File type: Adobe PDF

Comments: 0 | Viewed: 2 times | Downloaded: 1 time

This File has no tags!

File

Uploader

Blob http://scifed.com/fulltext/the-influenza-a-virus-sub...

Created: 2017-12-28 05:54:34

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

http://scifed.com/fulltext/the-influenza-a-virus-subtypes-h1n1-h1n2-and-h3n2-hdfx-a-novel-immunomodulatorand-potential-fighter-against-cytokine-storms-in-viral-flu-infections-carica-papaya-linn/21844#one

File type: Adobe PDF

Comments: 0 | Viewed: 3 times | Downloaded: 1 time

This File has no tags!

File

Uploader

Blob Krishnasarma pathy, (2017) The influenza A virus sub...

Created: 2017-11-20 11:10:44

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

The discovery of a new, biologic host-defense protein, “HDFx”, may provide a unique way to ameliorate and prevent the “cytokinestorms” and haemorrhages seen in severe influenza infections.The influenza A virus subtypes H1N1, H1N2 and H3N2 are prevalent inpig populations worldwide. All scientific data point towards swine as the key host species for new human influenza pandemics, whichhave been suggested to evolve in pigs from viral genes of avian, human and porcine orig...

File type: Adobe PDF

Comments: 0 | Viewed: 1 time | Downloaded: 1 time

This File has no tags!

File

Uploader

Blob Krishnasarma pathy, (2017) The influenza A virus sub...

Created: 2017-11-20 11:10:20

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

The discovery of a new, biologic host-defense protein, “HDFx”, may provide a unique way to ameliorate and prevent the “cytokinestorms” and haemorrhages seen in severe influenza infections.The influenza A virus subtypes H1N1, H1N2 and H3N2 are prevalent inpig populations worldwide. All scientific data point towards swine as the key host species for new human influenza pandemics, whichhave been suggested to evolve in pigs from viral genes of avian, human and porcine orig...

File type: Adobe PDF

Comments: 0 | Viewed: 2 times | Downloaded: 1 time

This File has no tags!

File

Uploader

Blob The influenza A virus subtypes H1N1, H1N2 and H3N2 ,...

Created: 2017-11-16 12:21:14

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

The influenza A virus subtypes H1N1, H1N2 and H3N2 ,HDFx: A NovelImmunomodulator and Potential Fighter Against Cytokine Storms inViral Flu Infections- Carica papaya Linn 

File type: Adobe PDF

Comments: 0 | Viewed: 2 times | Downloaded: 1 time

Tags:

File

Uploader

Blob Method Development and Pharmacological study of Chem...

Created: 2017-08-18 10:18:59

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

No description

File type: Adobe PDF

Comments: 0 | Viewed: 8 times | Downloaded: 2 times

This File has no tags!

File

Uploader

Blob Oxcarbazepine by HPLC Method

Created: 2017-04-12 10:18:08

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

~Oxcarbazepine is in a class of drug called anticonvulsants. It inhibits unusual electrical activity in the brain. Oxcarbazepine may help control seizures, but it does not cure the disease. However, this medication is also used for treatment of epilepsy. Oxcarbazepine HPLC chromatography determination method was developed to quantify the quality of the synthesized drug. The developed method was then validated for the determination of Oxcarbazepine The separation was achieved in a octylsilyl s...

File type: Adobe PDF

Comments: 0 | Viewed: 28 times | Downloaded: 3 times

This File has no tags!

File

Uploader

Blob 5 Batch Analysis,Guidance to the manufacturer and th...

Created: 2016-09-10 09:21:16

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

~~The term ‘5 – batch analysis’ originates from the US EPA guidelines for testing of pesticides. The term is accepted now by most regulatory bodies like EEC, Indian registration authorities namely CIB & RC and other countries as well. There are no guidelines of OECD for this study. The study is essential to determine the composition of the product with respect to the active ingredient and its associated impurities.

File type: Adobe PDF

Comments: 0 | Viewed: 4 times | Downloaded: 6 times

This File has no tags!

File

Uploader

Blob Industrial process for OXICONAZOLE Dr Krishnasarma P...

Created: 2012-07-24 11:38:44 | Last updated: 2013-06-21 09:49:15

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Industrial process for OXICONAZOLE Dr Krishnasarma PathyOxiconazole inhibits ergosterol biosynthesis, which is required forcytoplasmic membrane integrity of fungi. It acts to destabilize the fungal cyctochromeP450 51 enzyme (also known as Lanosterol 14-alpha demethylase). This is vital in thecell membrance structure of the fungus. Its inhibition leads to cell lysis. Oxiconazole hasalso been shown in inhibit DNA synthesis and suppress intracellular concentrations ofATP. Like other imidazole an...

File type: Adobe PDF

Comments: 0 | Viewed: 63 times | Downloaded: 107 times

Tags:

File

Uploader

Blob SILDENAFIL CITRATE (Viagra) IN ITS POLYMORPHIC FORMS

Created: 2013-04-08 05:17:04

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

 AN IMPROVED PROCESS FOR THE PREPARATION OF SILDENAFIL CITRATE (Viagra) IN ITS POLYMORPHIC FORM The present invention provides an improved process for preparation of 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H –pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulphonyl]-4methypiperazine citrate (Sildenafil Citrate) ofPolymorphic form I)

File type: Adobe PDF

Comments: 0 | Viewed: 212 times | Downloaded: 892 times

Tags:

File

Uploader

Blob synnthesis of Tris[ 2-pyridyl)methyl]amine

Created: 2012-09-14 09:57:46

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

No description

File type: Adobe PDF

Comments: 0 | Viewed: 13 times | Downloaded: 16 times

This File has no tags!

File

Uploader

Blob STUDY OF QUANTIFICATION OF IMPURITIES AND RELATED SU...

Created: 2012-08-13 16:46:39

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

    Bulk drug during its production process, after its scale up, it is necessary to analyse for the presence of any impurities or related substances in it. This is to ensure the impurities and related substances are within their limits as per ICH Guidelines. The impurities and related substances are defined as; Impurity: Any component present in the drug substance or drug product which is not the desired product, a product-related substance, or excipient including buffer com...

File type: Adobe PDF

Comments: 0 | Viewed: 183 times | Downloaded: 551 times

This File has no tags!

File

Uploader

Blob Process for the preparation of amorphous atorvastati...

Created: 2012-07-24 12:07:03

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Atorvastatin calcium is a drug compound that is used as a lipid-lowering agent, fortreating hypercholesterolemia. The compound has the chemical name[R-(R*,R*)]-2-(4-fluorophenyl)-3,ö-dihydroxy-5-(1-methylethyl)-3-phenyl-4-{(phenylamino)carbonyl}-1H-pyrolle-1-hepatonic acid, calcium salt (2:1) trihydrate. Pharmaceutical productscontaining crystalline atorvastatin calcium trihydrate are sold using the trademarkLIPITOR.

File type: Adobe PDF

Comments: 0 | Viewed: 46 times | Downloaded: 110 times

This File has no tags!

File

Uploader

Blob Novel polymorph of 5-cyanopthalide high purity inter...

Created: 2012-07-24 12:02:16

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

The present invention relates to obtaining a new polymorph of 5-Cyanophthalide in highly pure form (99.5 to 99.99%), which is an intermediate used forthe synthesis of citalopram& escitalopram both of which are potent antidepressant drugs.Moreover this new polymorph of 5-cyanophthalide does not contain impurities liketerephthalic acid & diphthalide derivatives.        

File type: Adobe PDF

Comments: 0 | Viewed: 45 times | Downloaded: 119 times

Tags:

File

Uploader

Blob Enantioselective method of synthesizing methylphenid...

Created: 2012-07-24 11:51:52

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Process for the preparation of enantioselective method of making methylphenidate and derivatives . The method involves use of a rhodium catalyst, and selectively produces the D-enantiomer of the methylphenidate derivative in excess of the L-enantiomer . Furthermore, the method selectively produces the threo-diastereomer in excess of the erythro-diastereomer. The method is thus suitable for synthesis of D-threo-methylphenidate (the biologically active form of this compound) and derivatives &...

File type: Adobe PDF

Comments: 0 | Viewed: 51 times | Downloaded: 75 times

Tags:

File

Uploader

Blob Quality Assurance and GMP and ICH

Created: 2012-07-24 11:46:03

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Quality Assurance is a planned and systematic approach to generate enough confidence in the quality of the product and processes in the long run as per the specifications." In this biog you will find post related to ICH, GMP and Quality related matters.

File type: Adobe PDF

Comments: 0 | Viewed: 21 times | Downloaded: 21 times

This File has no tags!

File

Uploader

Blob GLIBENCLAMIDE Complexes ( Complexes of Mg,Cr,Ni,Zn a...

Created: 2012-07-24 11:33:50 | Last updated: 2012-07-24 11:33:51

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

The N-acetyl derivative of β-phenethylamine is reacted with chlorosulfonic acid to form the para sulfonyl chloride derivative. This is then subjected to ammonolysis, followed by base-catalyzed removal of the acetamide. This is then acylated with 2-methoxy-5-chlorobenzoic acid chloride to give the amide intermediate. This is then reacted with cyclohexyl isocyanate to yield the sulfonylurea glibenclamide

File type: Adobe PDF

Comments: 0 | Viewed: 23 times | Downloaded: 28 times

This File has no tags!

File

Uploader

Blob HOW TO START ANALYTICAL METHOD DEVELOPMENT

Created: 2012-07-24 11:28:31

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

 A bulk drug during its production process, after its scale up, it is necessary to analyse for the presence of any impurities or related substances in it. This is to ensure the impurities and related substances are within their limits as per ICH Guidelines.The impurities and related substances are defined as; Impurity: Any component present in the drug substance or drug product which is not the desired product, a product-related substance, or excipient including buffer components. I...

File type: Adobe PDF

Comments: 0 | Viewed: 252 times | Downloaded: 856 times

This File has no tags!

File

Uploader

Blob DEFINITION “IMPURITY”

Created: 2012-07-24 11:18:54

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Impurities are normally generated during the formation of Active PharmaceuticalIngredients and their intermediates. Chances of their generation during Drug Productsformation are less as formulation is a physical blending process. Care is taken that theseexcipients do not react with each other to produce the degradants. They may consist oforganic and inorganic, and define levels at which impurities/degradants should beidentified.ICH Q3A covers drug substances and Q3B covers drug products. Th...

File type: Adobe PDF

Comments: 0 | Viewed: 17 times | Downloaded: 17 times

This File has no tags!

File

Uploader

Blob Improved process for preparing L-phenylephrine hydro...

Created: 2012-07-24 11:12:15

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

The present invention relates to an improved process for preparing L-phenylephrinehydrochloride on an industrial scale    

File type: Adobe PDF

Comments: 0 | Viewed: 124 times | Downloaded: 337 times

This File has no tags!

File

Uploader

Blob PROCESS FOR PREPARATIN OF VITAMIN-C-Dr.krishnasarma ...

Created: 2012-07-24 11:03:13

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Ascorbic acid (vitamin C) is a water-soluble vitamin. It occurs as a white or slightly yellowcrystal or powder with a slight acidic taste. It is an antiscorbutic product. On exposure to light, itgradually darkens. In the dry state, it is reasonably stable in air, but in solution it rapidlyoxidizes. Ascorbic acid (vitamin c) is freely soluble in water; sparingly soluble in alcohol;insoluble in chloroform, in ether, and in benzene. The chemical name of ascorbic acid (vitaminc) is L-ascorbic a...

File type: Adobe PDF

Comments: 0 | Viewed: 25 times | Downloaded: 75 times

This File has no tags!

File

Uploader

Blob Industrial process for preparation of Levetiracetam....

Created: 2012-07-24 10:59:51

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

         Levetiracetam belongs to the class of compounds used in the treatment of epilepsy so it.has huge demand in market and it is worth to develop the product.

File type: Adobe PDF

Comments: 0 | Viewed: 23 times | Downloaded: 81 times

This File has no tags!

File

Uploader

Blob solid-state forms of celecoxib andAN IMPROVED PROCE...

Created: 2012-07-24 10:54:47

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

          The present application provides an improved process for the preparation  of          4-[5-(4-methylphenyl)-3- (trifluoromethyl)-1H-pyrazol-1-yl] benzenesulfonamide           (Celecoxib) and its purification and crystallisation to produce polymorph .  

File type: Adobe PDF

Comments: 0 | Viewed: 37 times | Downloaded: 112 times

This File has no tags!

File

Uploader

Blob Amorphous solids - Pharmaceutical technology and d...

Created: 2012-07-24 10:45:30

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

No description

File type: Adobe PDF

Comments: 0 | Viewed: 6 times | Downloaded: 55 times

This File has no tags!

File

Uploader

Blob A Primer on Intellectual Property Rights-Dr.krishnas...

Created: 2012-07-24 10:39:44

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

  nTypes of Intellectual Property   nWhat is a Patent , its requirements & specification   nPatent claims   nCriteria for claiming inventors   nTypes of patents   nInfringement & validity of patent   nIndian patent scenario   nPatent Cooperation Treaty (PCT)   nDifferences in patent Laws   nPatent Resources  

File type: PowerPoint presentation

Comments: 0 | Viewed: 20 times | Downloaded: 32 times

This File has no tags!

Workflow

Uploader

Workflow analytical flow (1)

Thumb
No description

Created: 2012-09-17 | Last updated: 2012-09-21

Credits: User Drkrishnasarmapathy

Workflow

Workflow STUDY OF QUANTIFICATION OF IMPURITIES AND ... (1)

  Bulk drug during its production process, after its scale up, it is necessary to analyse for the presence of any impurities or related substances in it. This is to ensure the impurities and related substances are within their limits as per ICH Guidelines. Required brief study        The primary objective of the study is to develop HPLC method and validate it for the detection and quantification of impurities and related substances in the manufactu...

Created: 2012-09-16

Credits: User Drkrishnasarmapathy

What is this?

Linked Data

Non-Information Resource URI:


Alternative Formats

HTML
RDF
XML