File Entry: Bigunidine Metformin Pharmacologically Efficacious Than Herbal Therapies and Its Preparation, The Safest Biguanide Derivates in Use by T2dm Patients

Metformin usage may be considered for people with type 2 diabetes to help them control their blood sugar levels a secondary side
effect may be weight loss, which leads some to believe it may be a viable medication to use for weight loss. However, researchers are
still not clear on whether or not metformin has an actual impact on weight, or if weight loss is due to lifestyle changes in people with
type 2 diabetes. Metformin (Glucophage, Glumetza, Fortamet) is typically prescribed to counteract the effects of insulin resistance
-- the body’s sluggish response to the blood-sugar-lowering hormone insulin. Insulin resistance can lead to high blood sugars and
may eventually progress to prediabetes or type 2 diabetes (T2DM). Metformin improves insulin sensitivity of the body tissues and
reduces liver glucose production, both of which help lower blood sugar levels. The American Diabetes Association recommends metformin
as a first-choice medicine to treat T2DM. It is also sometimes used in combination with exercise and weight loss in people with
prediabetes. Some evidence suggests that a few herbs might mimic some of the effects of metformin. However, no herb is a proven
alternative to metformin