File Entry: SCHOLARLY JOURNAL OF FOOD AND NUTRITION-Route Evaluation and Analytical HPLC Method Development of Buprenorphine, Naloxone, and Comparison Overall Efficiency of Naltrexone Nalbuphine Traces the Evolution of Various Approaches

Created: 2018-06-04 05:32:46 Last updated: 2018-06-04 05:34:44

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Version created on: 2018-06-04 05:32:46

Last edited on: 2018-06-04 05:34:44

Title	SCHOLARLY JOURNAL OF FOOD AND NUTRITION-Route Evaluation and Analytical HPLC Method Development of Buprenorphine, Naloxone, and Comparison Overall Efficiency of Naltrexone Nalbuphine Traces the Evolution of Various Approaches
File name	Krishnasarma P. Route Evaluation and Analytical HPLC Method Development of Buprenorphine, Naloxone, and Comparison OverallSJFN.MS.ID.000105.pdf
File size	1707027
SHA1	a225748b69be9995e8c6fe6d62f1cd1e308d1640
Content type	Adobe PDF

Description

This is out line work on the process development for the synthesis of buprenorphine, naltrexone, naloxone, and nalbuphine from naturally occurring opiates such as Thebaine, also known as codeine methyl enol ether, and oripavine. Several new methods for N-demethylation of morphinans have been developed during the pursuit of this research. The article traces the evolution of various approaches and provides a comparison for overall efficiency. A reverse phase high performance liquid chromatographic (RPHPLC) method has been developed and validated for simultaneous estimation of Naloxone Hydrochloride and Buprenorphine Hydrochloride in pure and marketed formulations. Separation was carried out using column Hypersil ODS C18 (250 mm x 4.6mm x 5μm particle size) in isocratic mode using mobile pha.....