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Case History-The Control of Impurities-A Critical Is...

Created: 2018-08-01 05:35:55

Credits: Drkrishnasarmapathy

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Case History-The Control of Impurities-A CriticalIssue to The Active Pharmaceutical Ingredient

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Distribución de metales pesados en sedimentos superf...

Created: 2018-07-29 18:42:42

Credits: William Senior

License: Creative Commons Attribution-Share Alike 3.0 Unported License

La concentración total y las formas químicas de los metales pesados se determinaron en sedimentossuperficiales del Orinoco Medio, Venezuela, utilizando una solución 25% (v/v) de acidoacético/solución HNO3: HCl: HClO4 (3:2:1), espectrofotometría de absorción atómica con llama ytécnica de vapor en frio. El rango de los valores totales variaron entre 8871 a 116.759 μgFeg-1,102,45 a 469,44 μgMn g-1; 0,93 a 17,64 μgCu g-1; 4,4...

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DISTRIBUCIÓN Y ESPECIACIÓN DE ALGUNOS METALES PESADO...

Created: 2018-07-29 18:31:20

Credits: William Senior

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Se evaluó la distribución y especiación de los metales pesados Cd, Ni, Mn y Cu en sedimentos superficiales de tres áreas geográficas del oriente del país ubicadas en la Bahía de Guanta-Pertigalete, estado Anzoátegui, Venezuela. Las muestras fueron recolectadas utilizando una draga Diez Laffont de 0,02 m2 de área. Los sedimentos fueron sometidos a un proceso de extracción por pasos para extraer las diferentes fracciones geoq...

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DESCRIPCIÓN DE LAS CARACTERÍSTICAS FISICOQUÍMICAS DE...

Created: 2018-07-29 18:26:25

Credits: William Senior

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En Venezuela los estudios limnológicos en los grandes ríos como el Apure, el niño es debido a la complejidad de la logística sobre todo, para la captación de las muestras. En esta investigación se determinaron algunos parámetrosfisicoquímicos (nivel del río, conductividad, temperatura, pH, Oxígeno disuelto, Material en suspensión, turbidez, transparenciadel agua, nitrógeno total, nitrato, nitrito, amonio, f&oa...

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Estudio de la degradación de la materia orgánica en ...

Created: 2018-07-29 18:21:47

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Una muestra de agua colectada en el estuario de l´ Elorn (Brest-Francia), fue incubada durante 118 días en la oscuridad a temperatura ambiente

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Analyse des sucres par chromatographie liquide de ha...

Created: 2018-07-29 17:55:30 | Last updated: 2018-07-29 18:06:16

Credits: William Senior

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L´eau de mer contient en différents proportions les composés organiques les plus diverses.

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Corrientes superficiales en la Bahía de Bergantín (E...

Created: 2018-07-29 17:43:19

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Un conjunto de observaciones de corrientes superficiales realizadas por el Instituto Oceanográficode Venezuela en la Bahía de Bergantín, se obtuvieron durante algunos meses de1989. Ese conjunto de mediciones se analiza a la luz de nuevas metodologías; en particular sedescribe y analiza la naturaleza del registro de corriente y su posible vinculación con agentesforzantes. Se encuentra que: a) Opuesto a la creencia generalizada de que la bahía de Bergan...

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análisis espectral; contaminación costera; corrientes.

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CONTENIDO DE GRASA Y PROTEINA EN Pygocentrus cariba,...

Created: 2018-07-29 16:16:43

Credits: William Senior

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Se determinó la concentración de grasa y proteína en el tejido muscular de 40 peces de cada una de las especies Pygocentrus cariba, Prochilodus mariae, Plagioscion squamosissimus, Piaractus brachypomus e Hypostomus plecostomus,capturados en una laguna de inundación del rio Orinoco medio utilizando redes de enmalle. Los contenidos de proteína y grasa se determinaron por los métodos de la Asociación de Químico...

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Concentration of K, Na, Ca, Mg, Fe, proteins and fat...

Created: 2018-07-29 16:08:23

Credits: William Senior

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An analysis of the concentratlons of potassiurn, sodium. calcium. magnesiurn. tron, proteíns and fat, was made in the muscular tissue of the líned catftsh PseUliop laiystomajasciatLtm from the middle Orlnoco ínVenezuela, as a contribu tlon to the knowledge ofthe ecofisiology ofthe species and ofits importance from the nutritious point ofview. The salts were analyzed by Espectrofotometria ofAtomic AbsorpUon with fIame of air-acetylene and correction ofdeuterium bottom, usi...

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Concentraciones y comportamiento de metales pesados ...

Created: 2018-07-29 15:48:18

Credits: William Senior

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Existe una amplia gamade productos derivadosde las actividades humanasque, una vez vertidos a los ríos, costasy estuarios, causan alteraciones ecológicasespecificas. Tal es el caso de losmetales pesados. El Grupo de ExpertosSobre Aspectos Científicos de ContaminaciónMarina (GESAM) advierte sobrela imperativa y urgente necesidad decrear programas de seguimiento continuoen los ríos, estuarios y zonas costeras,para obtener información que permita dise&nt...

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Comportamiento de los metales trazas Cu, Pb, Mn y Zn...

Created: 2018-07-29 15:33:21

Credits: William Senior

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The concentrations of the metalsCu, Pb, Mn and Zn in fra ctions geochemistry insix sediment core of the lagoon Unare, Venezuela.A procedure of sequential extraction of metalswas determined, for each fraction was usedreagents different and conditions of digestionand the concentrations of metals determinedwith spectrophotometer of Atomic Absorption.The fractionating of metals indicated an order ofdecreasing concentration as it follows: residualfraction > organic/sulfur matter > carbonates...

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CARACTERÍSTICAS GEOQUÍMICAS DE LOS SEDIMENTOS SUPERF...

Created: 2018-07-29 15:22:35

Credits: William Senior

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Esta investigación tuvo como objetivo evaluar algunos parámetros geoquímicos de los sedimentos superficiales de la laguna costera La Restinga, ubicada en la Isla de Margarita, estado Nueva Esparta, Venezuela. Utilizando metodología clásica para estudios geoquímicos, se analizó la composición granulométrica y textura del sedimento, porcentaje de carbono orgánico y materia orgánica total, así como, carbonato de ...

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ASPECTOS GEOQUÍMICOS Y AMBIENTALES DE LOS SEDIMENTOS...

Created: 2018-07-29 15:02:41

Credits: William Senior

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La presente investigación tuvo por objetivo estudiar las características geoquímicas y las condiciones ambientales de los sedimentos del río Cuchivero, Venezuela, en función del tamaño de la partícula, materia orgánica, carbono orgánico, nitrógeno y fósforo total, carbonatos y metales pesados. La granulometría estuvo tipificada por un predominio de arenas con bajo contenido de materia orgánica (0,52-0,8...

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Seasonal Distribution of Nutrients and Primary Produ...

Created: 2018-07-29 14:32:14

Credits: William Senior

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Nutrientes nitrogenados, silicato disuelto y salinidad se midieron en aguas superficiales e hidropesias someras a lo largo de vías de crucero similares durante la primavera (estación seca) y otoño (estación húmeda) de 1988. Ambos cruceros transeccionaron el Caribe oriental, transitaron por el Golfo de Paria. paralelo al delta del Orinoco y al canal principal del río Orinoco. Las tendencias en la productividad primaria también se midieron median...

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Influencia del rio Manzanares en la biodisponibilida...

Created: 2018-07-29 01:32:16

Credits: William Senior

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Se estudian los niveles de metales pesados, Cr, Pb y Zn en la fracción biodisponible en sedimentos superficiales de la región marino-costera de la ciudad de Cumaná, Venezuela, durante los periodos de sequía y lluvia, en 17 estaciones de muestreo distribuidas a lo largo de la costa. Se encontró que hubo una diferencia entre los periodos de muestreo para el ciclo y el plomo, los cuales registraron grados máximos durante la temporada de lluvia. Para el r...

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Especiación química de fosforo en sedimentos superfi...

Created: 2018-07-29 00:49:47

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Método de extracción secuencial sedimentaria (SEDEX) modificado por ANDERSON & DELANEY (2000) para cuantificar cuatro reservorios de fósforo: (P-adsorbido o lábil más P-asociado a óxidos que correspondan a la fracción [F1], P- autigénico [F2], P-detrítico [F3] y P- orgánico [F4], en el sedimento del golfo de Paria y la costa Atlántica venezolana. El origen marino y continental en los sedimentos fue determinado me...

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Evaluación de la distribución del contenido total y ...

Created: 2018-07-29 00:38:31

Credits: William Senior

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La zona costera es una banda de amplitud variable de interacción eintercambio entre los ecosistemas; marino y terrestre. En esta zona, seencuentran los estuarios y cuencas hidrográficas asociadas. Estas zonas se hanconvertido en grandes sumideros de diversas sustancias, entre las que seencuentran los metales pesados, los cuales constituyen un grupo deelementos cuya abundancia en el ambiente marino ha sido muy estudiadadebido a su toxicidad (Moose et al., 1993). El aporte de meta...

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CARACTERÍSTICAS GEOQUÍMICAS DE LOS SEDIMENTOS SUPERF...

Created: 2018-07-29 00:11:15

Credits: William Senior

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Esta investigación tuvo como objetivo evaluar algunos parámetros geoquímicos de los sedimentos superficiales de la laguna costera La Restinga, ubicada en la Isla de Margarita, estado Nueva Esparta, Venezuela. Utilizando metodología clásica para estudios geoquímicos, se analizó la composición granulométrica y textura del sedimento, porcentaje de carbono orgánico y materia orgánica total, así como, carbonato de ...

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Metales pesados (cadmio, plomo, mercurio) y arsénico...

Created: 2018-07-28 22:55:25

Credits: William Senior

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Se realizó un estudio preliminar sobre el contenidode cadmio (Cd), plomo (Pb), mercurio (Hg) yarsénico (As) en muestras de fi letes de pescadocongelado de elevado consumo en El Ecuadorcomo, corvina (Cynoscion phoxocephalus), dorado(Coryphaena hippurus), tilapia (Oreochromisniloticus) y atún (Thunnus obesus); adquiridos endiversos supermercados de la ciudad de Machala,Provincia El Oro. Los resultados preliminaresmuestran la contaminación de estos productos porAs, Pb...

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Estado de conservación del sistema hidrográfico del ...

Created: 2018-07-28 22:37:39

Credits: William Senior

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El río Manzanares tiene una relación histórica con la ciudad de Cumaná, ya sea por su papelecológico, cultural y económico pero también por los impactos ambientales que han afectadonegativamente el estado de conservación de este hidrosistema. Se efectuó una actualización de lainformación sobre el estado de conservación del río Manzanares y sus tributarios con base en larevisión de artículo...

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Especiación Química y Biodisponibilidad del Fósforo ...

Created: 2018-07-28 21:08:16

Credits: William Senior

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En esta investigación se determinaron las fracciones P-adsorbida o lábil (F1), P-autigénica (F2), P-asociada a óxidos (F3), P-detrítica (F4) y P-orgánica (F5), y la biodisponibilidad del fósforo en los sedimentos del Golfo de Paria, Venezuela. La concentración de fósforo total (PT) osciló entre 3,93-4,97 μmol P/g, y se encuentra principalmente en forma detrítica y orgánica. Se evidencian diferentes mecanism...

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Herald Scholarly Open Access Pathy K (2018) Entecavi...

Created: 2018-07-28 07:03:39

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Herald Scholarly Open Access krishnasarma Pathy K (2018) Entecavir Patent Evaluation & Genotoxicity.pdf

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Herald Scholarly Open Accesskrishnasarma Pathy K (20...

Created: 2018-07-28 07:01:30 | Last updated: 2018-07-28 07:01:52

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Herald Scholarly Open Accesskrishnasarma Pathy K (2018) Entecavir Patent Evaluation & Genotoxicity.

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Krishnasarma Pathy (2018) Process for Preparation of...

Created: 2018-07-14 06:13:35

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Krishnasarma Pathy (2018) Process for Preparation of Vitamin C and Method for Determination of Vitamin C in Tablets. SF J Chem Res 2:1.

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Method for Preparation of Vitamin C and Method for D...

Created: 2018-07-14 06:12:11

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Procedure for calcium ascorbate (VITAMIN-C) includes such technological steps as reaction of ascorbic acidon calcium carbonate in water in recent years; the determination of vitamin C has become an important subject in the fieldof biochemistry and commercial foods. This is because vitamin C plays an important role in maintaining human health.Due to the importance of vitamin C in human beings, the quantitative analysis of vitamin C has gained a significantincrease in several areas of analytica...

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Estado de conservación del sistema hidrográfico del ...

Created: 2018-07-10 09:12:04

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El río Manzanares tiene una relación histórica con la ciudad de Cumaná, ya sea por su papelecológico, cultural y económico pero también por los impactos ambientales que han afectadonegativamente el estado de conservación de este hidrosistema. Se efectuó una actualización de lainformación sobre el estado de conservación del río Manzanares y sus tributarios con base en larevisión de artículo...

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Especiación Química y Biodisponibilidad del Fósforo ...

Created: 2018-07-10 08:45:00 | Last updated: 2018-07-10 09:01:19

Credits: William Senior

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En esta investigación se determinaron las fracciones P-adsorbida o lábil (F1), P-autigénica (F2), P-asociada a óxidos (F3), P-detrítica (F4) y P-orgánica (F5), y la biodisponibilidad del fósforo en los sedimentos del Golfo de Paria, Venezuela. La concentración de fósforo total (PT) osciló entre 3,93-4,97 μmol P/g, y se encuentra principalmente en forma detrítica y orgánica. Se evidencian diferentes mecanism...

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Entecavir Patent Evaluation, Method for Diastereomer...

Created: 2018-06-29 10:47:08 | Last updated: 2018-06-29 10:48:15

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Entecavir Patent Evaluation, Method for Diastereomeric ImpuritiesEntecavir is an oral antiviral drug used in the treatment of hepatitis B infection. Entecavir is a guanosine nucleoside analogue with selective activity against hepatitis B virus (HBV), which inhibits reverse transcription, The initial patent on entecavir expired in South Africa in 2011 ZA 1991/07894. Current status available on: http://patentsearch.cipc.co.za/, which should have permitted lower-cost generic competitors to enter...

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Organic and Medicinal Chemistry International Journa...

Created: 2018-06-29 10:43:43

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Organic and Medicinal Chemistry International Journal:Entecavir Patent Evaluation, Method for Diastereomeric ImpuritiesEntecavir is an oral antiviral drug used in the treatment of hepatitis B infection. Entecavir is a guanosine nucleoside analogue with selective activity against hepatitis B virus (HBV), which inhibits reverse transcription, The initial patent on entecavir expired in South Africa in 2011 ZA 1991/07894. Current status available on: http://patentsearch.cipc.co.za/, which should ...

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krishnasarmapathy-Entecavir Patent Evaluation, Molec...

Created: 2018-06-21 05:38:08

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Entecavir is an oral antiviral drug used in the treatment of hepatitis B infection. Entecavir is a guanosine nucleoside analogue with selective activity against hepatitis B virus (HBV), which inhibits reverse transcription, Hepatitis B virus (HBV) is highly endemic in South Africa and across sub-Saharan Africa, where around 8% of people are chronically infected, and rates of HBV-related liver cancer are some of the highest in the world. Globally, viral hepatitis causes approximately 1.3 milli...

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Entecavir Patent Evaluation, Molecular Modelling Stu...

Created: 2018-06-21 05:36:07

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Entecavir is an oral antiviral drug used in the treatment of hepatitis B infection. Entecavir is a guanosine nucleoside analogue with selective activity against hepatitis B virus (HBV), which inhibits reverse transcription, Hepatitis B virus (HBV) is highly endemic in South Africa and across sub-Saharan Africa, where around 8% of people are chronically infected, and rates of HBV-related liver cancer are some of the highest in the world. Globally, viral hepatitis causes approximately 1.3 milli...

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Process for Preparation of Vitamin C and Method for ...

Created: 2018-06-19 06:44:55

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Process for Preparation of Vitamin C and Method for Determination of Vitamin C in Tablets

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Process for Preparation of Vitamin C and Method for ...

Created: 2018-06-19 06:43:19 | Last updated: 2018-06-19 06:43:37

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Process for Preparation of Vitamin C and Method for Determination of Vitamin C in Tablets

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SCHOLARLY JOURNAL OF FOOD AND NUTRITION-Route Evalua...

Created: 2018-06-04 05:32:46 | Last updated: 2018-06-04 05:34:44

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This is out line work on the process development for the synthesis of buprenorphine, naltrexone, naloxone, and nalbuphine from naturally occurring opiates such as Thebaine, also known as codeine methyl enol ether, and oripavine. Several new methods for N-demethylation of morphinans have been developed during the pursuit of this research. The article traces the evolution of various approaches and provides a comparison for overall efficiency. A reverse phase high performance liquid chromatograp...

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Route Evaluation and Analytical HPLC Method Developm...

Created: 2018-06-04 05:30:06 | Last updated: 2018-06-04 05:30:26

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This is out line work on the process development for the synthesis of buprenorphine, naltrexone, naloxone, and nalbuphine from naturally occurring opiates such as Thebaine, also known as codeine methyl enol ether, and oripavine. Several new methods for N-demethylation of morphinans have been developed during the pursuit of this research. The article traces the evolution of various approaches and provides a comparison for overall efficiency. A reverse phase high performance liquid chromatograp...

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process development of antiviral agents : Amantadin...

Created: 2018-05-05 07:09:19

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Recent advances in process development of antiviral agents targeting the influenza virus: Amantadine-Remantadine-derived pharmaceutical agents"

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Recent advances in process development of antiviral ...

Created: 2018-05-05 07:08:14

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Recent advances in process development of antiviral agents targeting the influenza virus: Amantadine-Remantadine-derived pharmaceutical agents"

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IJMSCI Recent advances in process development of ant...

Created: 2018-05-05 07:07:31

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Recent advances in process development of antiviral agents targeting the influenza virus: Amantadine-Remantadine-derived pharmaceutical agents"

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Bigunidine Metformin Pharmacologically Efficacious T...

Created: 2018-03-23 07:50:58

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Metformin usage may be considered for people with type 2 diabetes to help them control their blood sugar levels a secondary sideeffect may be weight loss, which leads some to believe it may be a viable medication to use for weight loss. However, researchers arestill not clear on whether or not metformin has an actual impact on weight, or if weight loss is due to lifestyle changes in people withtype 2 diabetes. Metformin (Glucophage, Glumetza, Fortamet) is typically prescribed to counteract th...

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Bigunidine Metformin Pharmacologically Efficacious T...

Created: 2018-03-23 07:49:08

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Metformin usage may be considered for people with type 2 diabetes to help them control their blood sugar levels a secondary sideeffect may be weight loss, which leads some to believe it may be a viable medication to use for weight loss. However, researchers arestill not clear on whether or not metformin has an actual impact on weight, or if weight loss is due to lifestyle changes in people withtype 2 diabetes. Metformin (Glucophage, Glumetza, Fortamet) is typically prescribed to counteract th...

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Synthesis of Sildenafil Citrate Validated HPLC Metho...

Created: 2018-03-23 07:47:52

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The present study describes analytical method of 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H–pyrazolo[4,3-d]pyrimidin-5-yl)-4- ethoxyphenyl]sulphonyl]-4methypiperazine citrate (sildenafil Citrate). The following specification particularly describes and ascertains the nature of this invention, and the manner in which it is to be performed. Sildenafil is an oral drug used primarily to treat male sexual function problems (impotence or erectile dysfunction) since becoming available in 199...

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Synthesis of Sildenafil Citrate Validated HPLC Metho...

Created: 2018-03-23 07:46:48

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

The present study describes analytical method of 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H–pyrazolo[4,3-d]pyrimidin-5-yl)-4- ethoxyphenyl]sulphonyl]-4methypiperazine citrate (sildenafil Citrate). The following specification particularly describes and ascertains the nature of this invention, and the manner in which it is to be performed. Sildenafil is an oral drug used primarily to treat male sexual function problems (impotence or erectile dysfunction) since becoming available in 199...

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Antihistamine Drugs Possess some Antiacetylcholine P...

Created: 2018-03-10 06:27:28

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Antihistamine Drugs Possess someAntiacetylcholine Properties

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Epidemic Flu Viruses & the influenza a virus

Created: 2018-03-10 06:26:15

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Epidemic Flu Viruses & the influenza a virus

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Nutri Food Sci Int J 5(5): NFSIJ.MS.ID.555674 (2018)...

Created: 2018-03-10 06:24:50

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Nutri Food Sci Int J 5(5): NFSIJ.MS.ID.555674 (2018) 001

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CONCENTRACIÓN DE METALES PESADOS EN BIVALVOS Anadara...

Created: 2018-03-09 21:41:04

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The concentrations of heavy metals in the bivalve molluscs Anadara similis and A. tuberculosa are determined. The specimens were collected at 2 km from the mouth of Estero Huaylá, El Oro Province, Ecuador, in November 2013. The length and weight of each species were determined in the laboratory, with two length ranges being established for A. similis and four for A. tuberculosa. The meat of the organisms was extracted, washed and dried in an oven at 60 ° C for 72 h, then digested w...

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Krishnasarma Pathy* DOI: 10.19080/OAJT.2018.02.55559...

Created: 2018-03-09 08:06:21

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Epidemic Flu Viruses & the influenza a virus subtypes H1N1, H1N2 and H3N2, HDFxKrishnasarma Pathy*Head of QC/QA, IPL Research Centre, IndiaSubmission: October 31, 2017; Published: March 07, 2018*Corresponding author: Krishnasarma Pathy, Head of QC/QA, IPL Research Centre, India, Tel: 9919188895,Email:Open Acc J of Toxicol. 2018; 2(4): OAJT.MS.ID.555593 (2018)001Mini ReviewThe history of flu viruses teaches that the influence has origin from animal’s birds, generically aquatic, and t...

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Krishnasarma Pathy*Flu Viruses Open Acc J of Toxicol...

Created: 2018-03-09 08:04:06

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Krishnasarma Pathy*Head of QC/QA, IPL Research Centre, IndiaSubmission: October 24, 2017; Published: March 07, 2018*Corresponding author: Krishnasarma Pathy, Head of QC/QA, IPL Research Centre, India, Tel: 9919188895Human H1N1 pandemic developed from the originally localized Mexican source early in the spring 2009. For the emergency created by the epidemic of influence of the pigs in Mexico it was correct not to create alarmism being victims of bad information. Cytokine storm should be mentio...

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Abstract Human H1N1 pandemic developed from the orig...

Created: 2018-03-08 10:54:10

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For the emergency created by the epidemic of influence of the pigs in Mexico it was correct not to create alarmisms being victims of a bad information. The possibility that the virus arrives in other parts of the world is real as for all the types of influence virus. In order that a strain has a wide distribution, its antigenic characteristics must ensure that it escapes the neutralization of antibodies of the host and of the surrounding population. The discovery of a new, biologic Host-Defen...

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FLUVIRUSES

Created: 2018-03-08 10:51:51 | Last updated: 2018-03-08 10:52:22

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AbstractHuman H1N1 pandemic developed from the originally localized Mexican source early in the spring 2009. For the emergency created by the epidemic of influence of the pigs in Mexico it was correct not to create alarmism being victims of bad information. Cytokine storm should be mentioned as one of the key pathogenic events contributing to the overall mortality in substantial portion of patients. If active immunization is assumed to be preventive measure of proven efficacy, clinicians are ...

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