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Route Evaluation and Analytical HPLC Method Developm...

Created: 2018-06-04 05:30:06 | Last updated: 2018-06-04 05:30:26

Credits: Drkrishnasarmapathy

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This is out line work on the process development for the synthesis of buprenorphine, naltrexone, naloxone, and nalbuphine from naturally occurring opiates such as Thebaine, also known as codeine methyl enol ether, and oripavine. Several new methods for N-demethylation of morphinans have been developed during the pursuit of this research. The article traces the evolution of various approaches and provides a comparison for overall efficiency. A reverse phase high performance liquid chromatograp...

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process development of antiviral agents : Amantadin...

Created: 2018-05-05 07:09:19

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Recent advances in process development of antiviral agents targeting the influenza virus: Amantadine-Remantadine-derived pharmaceutical agents"

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Recent advances in process development of antiviral ...

Created: 2018-05-05 07:08:14

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Recent advances in process development of antiviral agents targeting the influenza virus: Amantadine-Remantadine-derived pharmaceutical agents"

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IJMSCI Recent advances in process development of ant...

Created: 2018-05-05 07:07:31

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Recent advances in process development of antiviral agents targeting the influenza virus: Amantadine-Remantadine-derived pharmaceutical agents"

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Bigunidine Metformin Pharmacologically Efficacious T...

Created: 2018-03-23 07:50:58

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Metformin usage may be considered for people with type 2 diabetes to help them control their blood sugar levels a secondary sideeffect may be weight loss, which leads some to believe it may be a viable medication to use for weight loss. However, researchers arestill not clear on whether or not metformin has an actual impact on weight, or if weight loss is due to lifestyle changes in people withtype 2 diabetes. Metformin (Glucophage, Glumetza, Fortamet) is typically prescribed to counteract th...

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Bigunidine Metformin Pharmacologically Efficacious T...

Created: 2018-03-23 07:49:08

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Metformin usage may be considered for people with type 2 diabetes to help them control their blood sugar levels a secondary sideeffect may be weight loss, which leads some to believe it may be a viable medication to use for weight loss. However, researchers arestill not clear on whether or not metformin has an actual impact on weight, or if weight loss is due to lifestyle changes in people withtype 2 diabetes. Metformin (Glucophage, Glumetza, Fortamet) is typically prescribed to counteract th...

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Synthesis of Sildenafil Citrate Validated HPLC Metho...

Created: 2018-03-23 07:47:52

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The present study describes analytical method of 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H–pyrazolo[4,3-d]pyrimidin-5-yl)-4- ethoxyphenyl]sulphonyl]-4methypiperazine citrate (sildenafil Citrate). The following specification particularly describes and ascertains the nature of this invention, and the manner in which it is to be performed. Sildenafil is an oral drug used primarily to treat male sexual function problems (impotence or erectile dysfunction) since becoming available in 199...

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Synthesis of Sildenafil Citrate Validated HPLC Metho...

Created: 2018-03-23 07:46:48

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The present study describes analytical method of 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H–pyrazolo[4,3-d]pyrimidin-5-yl)-4- ethoxyphenyl]sulphonyl]-4methypiperazine citrate (sildenafil Citrate). The following specification particularly describes and ascertains the nature of this invention, and the manner in which it is to be performed. Sildenafil is an oral drug used primarily to treat male sexual function problems (impotence or erectile dysfunction) since becoming available in 199...

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Antihistamine Drugs Possess some Antiacetylcholine P...

Created: 2018-03-10 06:27:28

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Antihistamine Drugs Possess someAntiacetylcholine Properties

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Epidemic Flu Viruses & the influenza a virus

Created: 2018-03-10 06:26:15

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Epidemic Flu Viruses & the influenza a virus

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Nutri Food Sci Int J 5(5): NFSIJ.MS.ID.555674 (2018)...

Created: 2018-03-10 06:24:50

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Nutri Food Sci Int J 5(5): NFSIJ.MS.ID.555674 (2018) 001

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Krishnasarma Pathy* DOI: 10.19080/OAJT.2018.02.55559...

Created: 2018-03-09 08:06:21

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Epidemic Flu Viruses & the influenza a virus subtypes H1N1, H1N2 and H3N2, HDFxKrishnasarma Pathy*Head of QC/QA, IPL Research Centre, IndiaSubmission: October 31, 2017; Published: March 07, 2018*Corresponding author: Krishnasarma Pathy, Head of QC/QA, IPL Research Centre, India, Tel: 9919188895,Email:Open Acc J of Toxicol. 2018; 2(4): OAJT.MS.ID.555593 (2018)001Mini ReviewThe history of flu viruses teaches that the influence has origin from animal’s birds, generically aquatic, and t...

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Krishnasarma Pathy*Flu Viruses Open Acc J of Toxicol...

Created: 2018-03-09 08:04:06

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Krishnasarma Pathy*Head of QC/QA, IPL Research Centre, IndiaSubmission: October 24, 2017; Published: March 07, 2018*Corresponding author: Krishnasarma Pathy, Head of QC/QA, IPL Research Centre, India, Tel: 9919188895Human H1N1 pandemic developed from the originally localized Mexican source early in the spring 2009. For the emergency created by the epidemic of influence of the pigs in Mexico it was correct not to create alarmism being victims of bad information. Cytokine storm should be mentio...

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Abstract Human H1N1 pandemic developed from the orig...

Created: 2018-03-08 10:54:10

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For the emergency created by the epidemic of influence of the pigs in Mexico it was correct not to create alarmisms being victims of a bad information. The possibility that the virus arrives in other parts of the world is real as for all the types of influence virus. In order that a strain has a wide distribution, its antigenic characteristics must ensure that it escapes the neutralization of antibodies of the host and of the surrounding population. The discovery of a new, biologic Host-Defen...

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FLUVIRUSES

Created: 2018-03-08 10:51:51 | Last updated: 2018-03-08 10:52:22

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AbstractHuman H1N1 pandemic developed from the originally localized Mexican source early in the spring 2009. For the emergency created by the epidemic of influence of the pigs in Mexico it was correct not to create alarmism being victims of bad information. Cytokine storm should be mentioned as one of the key pathogenic events contributing to the overall mortality in substantial portion of patients. If active immunization is assumed to be preventive measure of proven efficacy, clinicians are ...

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http://scifed.com/fulltext/the-influenza-a-virus-sub...

Created: 2017-12-28 05:55:47 | Last updated: 2017-12-28 05:55:56

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http://scifed.com/fulltext/the-influenza-a-virus-subtypes-h1n1-h1n2-and-h3n2-hdfx-a-novel-immunomodulatorand-potential-fighter-against-cytokine-storms-in-viral-flu-infections-carica-papaya-linn/21844#one

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http://scifed.com/fulltext/the-influenza-a-virus-sub...

Created: 2017-12-28 05:54:34

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http://scifed.com/fulltext/the-influenza-a-virus-subtypes-h1n1-h1n2-and-h3n2-hdfx-a-novel-immunomodulatorand-potential-fighter-against-cytokine-storms-in-viral-flu-infections-carica-papaya-linn/21844#one

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Krishnasarma pathy, (2017) The influenza A virus sub...

Created: 2017-11-20 11:10:44

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The discovery of a new, biologic host-defense protein, “HDFx”, may provide a unique way to ameliorate and prevent the “cytokinestorms” and haemorrhages seen in severe influenza infections.The influenza A virus subtypes H1N1, H1N2 and H3N2 are prevalent inpig populations worldwide. All scientific data point towards swine as the key host species for new human influenza pandemics, whichhave been suggested to evolve in pigs from viral genes of avian, human and porcine orig...

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Krishnasarma pathy, (2017) The influenza A virus sub...

Created: 2017-11-20 11:10:20

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The discovery of a new, biologic host-defense protein, “HDFx”, may provide a unique way to ameliorate and prevent the “cytokinestorms” and haemorrhages seen in severe influenza infections.The influenza A virus subtypes H1N1, H1N2 and H3N2 are prevalent inpig populations worldwide. All scientific data point towards swine as the key host species for new human influenza pandemics, whichhave been suggested to evolve in pigs from viral genes of avian, human and porcine orig...

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The influenza A virus subtypes H1N1, H1N2 and H3N2 ,...

Created: 2017-11-16 12:21:14

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The influenza A virus subtypes H1N1, H1N2 and H3N2 ,HDFx: A NovelImmunomodulator and Potential Fighter Against Cytokine Storms inViral Flu Infections- Carica papaya Linn

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Oxcarbazepine by HPLC Method

Created: 2017-04-12 10:18:08

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~Oxcarbazepine is in a class of drug called anticonvulsants. It inhibits unusual electrical activity in the brain. Oxcarbazepine may help control seizures, but it does not cure the disease. However, this medication is also used for treatment of epilepsy. Oxcarbazepine HPLC chromatography determination method was developed to quantify the quality of the synthesized drug. The developed method was then validated for the determination of Oxcarbazepine The separation was achieved in a octylsilyl s...

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5 Batch Analysis,Guidance to the manufacturer and th...

Created: 2016-09-10 09:21:16

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~~The term ‘5 – batch analysis’ originates from the US EPA guidelines for testing of pesticides. The term is accepted now by most regulatory bodies like EEC, Indian registration authorities namely CIB & RC and other countries as well. There are no guidelines of OECD for this study. The study is essential to determine the composition of the product with respect to the active ingredient and its associated impurities.

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SILDENAFIL CITRATE (Viagra) IN ITS POLYMORPHIC FORMS

Created: 2013-04-08 05:17:04

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AN IMPROVED PROCESS FOR THE PREPARATION OF SILDENAFIL CITRATE (Viagra) IN ITS POLYMORPHIC FORM The present invention provides an improved process for preparation of 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H –pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulphonyl]-4methypiperazine citrate (Sildenafil Citrate) ofPolymorphic form I)

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STUDY OF QUANTIFICATION OF IMPURITIES AND RELATED SU...

Created: 2012-08-13 16:46:39

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Bulk drug during its production process, after its scale up, it is necessary to analyse for the presence of any impurities or related substances in it. This is to ensure the impurities and related substances are within their limits as per ICH Guidelines. The impurities and related substances are defined as; Impurity: Any component present in the drug substance or drug product which is not the desired product, a product-related substance, or excipient including buffer com...

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Process for the preparation of amorphous atorvastati...

Created: 2012-07-24 12:07:03

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Atorvastatin calcium is a drug compound that is used as a lipid-lowering agent, fortreating hypercholesterolemia. The compound has the chemical name[R-(R*,R*)]-2-(4-fluorophenyl)-3,ö-dihydroxy-5-(1-methylethyl)-3-phenyl-4-{(phenylamino)carbonyl}-1H-pyrolle-1-hepatonic acid, calcium salt (2:1) trihydrate. Pharmaceutical productscontaining crystalline atorvastatin calcium trihydrate are sold using the trademarkLIPITOR.

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