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Blob HOW TO START ANALYTICAL METHOD DEVELOPMENT

Created: 2012-07-24 11:28:31

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

 A bulk drug during its production process, after its scale up, it is necessary to analyse for the presence of any impurities or related substances in it. This is to ensure the impurities and related substances are within their limits as per ICH Guidelines.The impurities and related substances are defined as; Impurity: Any component present in the drug substance or drug product which is not the desired product, a product-related substance, or excipient including buffer components. I...

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Blob DEFINITION “IMPURITY”

Created: 2012-07-24 11:18:54

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Impurities are normally generated during the formation of Active PharmaceuticalIngredients and their intermediates. Chances of their generation during Drug Productsformation are less as formulation is a physical blending process. Care is taken that theseexcipients do not react with each other to produce the degradants. They may consist oforganic and inorganic, and define levels at which impurities/degradants should beidentified.ICH Q3A covers drug substances and Q3B covers drug products. Th...

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Blob Improved process for preparing L-phenylephrine hydro...

Created: 2012-07-24 11:12:15

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

The present invention relates to an improved process for preparing L-phenylephrinehydrochloride on an industrial scale    

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Blob PROCESS FOR PREPARATIN OF VITAMIN-C-Dr.krishnasarma ...

Created: 2012-07-24 11:03:13

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Ascorbic acid (vitamin C) is a water-soluble vitamin. It occurs as a white or slightly yellowcrystal or powder with a slight acidic taste. It is an antiscorbutic product. On exposure to light, itgradually darkens. In the dry state, it is reasonably stable in air, but in solution it rapidlyoxidizes. Ascorbic acid (vitamin c) is freely soluble in water; sparingly soluble in alcohol;insoluble in chloroform, in ether, and in benzene. The chemical name of ascorbic acid (vitaminc) is L-ascorbic a...

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Blob Industrial process for preparation of Levetiracetam....

Created: 2012-07-24 10:59:51

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

         Levetiracetam belongs to the class of compounds used in the treatment of epilepsy so it.has huge demand in market and it is worth to develop the product.

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Blob solid-state forms of celecoxib andAN IMPROVED PROCE...

Created: 2012-07-24 10:54:47

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

          The present application provides an improved process for the preparation  of          4-[5-(4-methylphenyl)-3- (trifluoromethyl)-1H-pyrazol-1-yl] benzenesulfonamide           (Celecoxib) and its purification and crystallisation to produce polymorph .  

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Blob A Primer on Intellectual Property Rights-Dr.krishnas...

Created: 2012-07-24 10:39:44

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

  nTypes of Intellectual Property   nWhat is a Patent , its requirements & specification   nPatent claims   nCriteria for claiming inventors   nTypes of patents   nInfringement & validity of patent   nIndian patent scenario   nPatent Cooperation Treaty (PCT)   nDifferences in patent Laws   nPatent Resources  

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Blob Using A Dynamic Bayesian Network-based Model for Inf...

Created: 2012-07-24 04:51:56

Credits: User Mohd Saberi

License: Creative Commons Attribution-Share Alike 3.0 Unported License

 Largely due to the technological advances in bioinformatics, researchers are now garnering interests in inferring gene regulatory networks (GRNs) from gene expression data which is otherwise unfeasible in the past. This is because of the need of researchers to uncover the potentially vast information and understand the dynamic behavior of the GRNs. In this regard, dynamic Bayesian network (DBN) has been broadly utilized for the inference of GRNs thanks to its ability to handle time-seri...

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Blob Aspartate Biosynthesis Pathway Simulation Using an I...

Created: 2012-07-24 04:49:23

Credits: User Mohd Saberi

License: Creative Commons Attribution-Share Alike 3.0 Unported License

 An improved Differential Evolution algorithm (IDE) is proposed in this paper. It is aimed at enhancing its efficiency in estimating the relevant kinetic parameters for metabolic pathway data to simulate aspartate biosynthesis pathway for plant model Arabidopsis. Metabolic pathway data are anticipated to be of vital help in the development of effectual tools in parameter estimation and kinetic modeling platforms. However, a number of computation algorithms face difficulty, produces low a...

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Blob Gene Knockout Strategies Identification by Using a H...

Created: 2012-07-24 04:48:16

Credits: User Mohd Saberi

License: Creative Commons Attribution-Share Alike 3.0 Unported License

 By optimizing microbial strains it is possible to improve product yield or improve growth characteristics. Microbial strains can be optimized through genetic engineering. It is proven that through genetic engineering it is able to obtain the desirable phenotypes. However, it is difficult to predict the effects of genetic modifications on the resulting phenotype due to the complexity of the networks. Optimization algorithms are implemented in previous works in order to identify the effec...

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