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4450?size=60x60 In Drkrish...
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Blob HCV NS3/4A 3 Protease Inhibitors: Simeprevir, Proces...

Created: 2020-02-19 06:12:03

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

In polymerase and protease drug targets and drug development, which has resulted in a strong infectious disease R&D portfolio,”and has given the company its key pipeline asset, simeprevir (TMC435), a novel protease inhibitor in Phase III clinicaldevelopment for hepatitis C that is being developed in collaboration with Janssen Pharmaceuticals. Currently, hepatitis C virus(HCV) infection is considered a serious health-care problem all over the world. A good number of direct-acting ant...

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Blob Chronic Hepatitis (Chc), Viral Polymerase Nucleotide...

Created: 2019-10-12 11:22:31

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Sofosbuvir is a viral polymerase nucleotide inhibitor that was approved in December2013 by the United States Food and Drug Administration (FDA), and in January 2014by the European Medicines Agency for the treatment of HCV infection [1]. The WHOGuidelines for the screening, care and treatment of persons with hepatitis C infectionrecommend sofosbuvir in combination with ribavirin in genotypes 1, 2, 3 and 4 HCVinfection, either with or without pegylated interferon (depending on the HCV genotype)...

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4540?size=60x60 Us Joshua Borycz
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Blob Test

Created: 2019-10-03 17:25:58

Credits: User Joshua Borycz

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Test

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Blob Bempedoic Acid a Small Molecule Drug Process and Syn...

Created: 2019-07-23 07:04:13

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Low Density Lipoprotein Cholesterol AbstractBempedoic acid (ETC-1002), a small molecule drug, promotes low density lipoprotein (LDL) receptor mediated clearanceof LDL-cholesterol (LDL-C) by inhibition of adenosine triphosphate citrate lyase (ACL), a mechanism complementary to thoseof existing lipid-modifying therapies. Bempedoic acid is a pro-drug activated specifically within the liver where it inhibits ACL,a regulatory checkpoint within the cholesterol biosynthesis pathway. By inhibiti...

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Blob Crystallization and Polymorphism-Scalable Process fo...

Created: 2018-12-04 11:45:47

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Crystallization and Polymorphism-Scalable Process for Celecoxib and It’s Polymorph From-3

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Blob Citation: Krishnasarma P, MS Chakravarthy. Crystalli...

Created: 2018-12-04 11:43:44

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Citation: Krishnasarma P, MS Chakravarthy. Crystallization and Polymorphism-Scalable Process for Celecoxib and It’s Polymorph From-3(Non- Steroidal Anti-Inflammatory Drug (NSAID). LOJ Med Sci 2(2)-2018. LOJMS.MS.ID.000134. 125Review ArticleCrystallization and Polymorphism-Scalable Process forCelecoxib and It’s Polymorph From-3 (Non- SteroidalAnti-Inflammatory Drug (NSAID) 

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Blob Cefpodoxime Proxetil and its By-Products: A Comparat...

Created: 2018-08-31 07:40:48

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Cefpodoxime Proxetil and its By-Products: A Comparative Study as Per EP-7 Krishnasarma pathy*LOJ Med Sci 

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Blob Biomedical Journal of Scientific & Technical Research.

Created: 2018-08-31 06:24:53

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Considerations for Successful Scale-Up to Tox Batches and Phase-Api (Bulk Drug substance)[*]       Krishnasarma pathy* DOI : 10.26717/BJSTR.2018.08.001662Biomedical Journal of Scientific & Technical Research.

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Blob Biomedical Journal of Scientific & Technical Researc...

Created: 2018-08-31 06:23:50

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Considerations for Successful Scale-Up to Tox Batches and Phase-Api (Bulk Drug substance)[*]       Krishnasarma pathy* DOI : 10.26717/BJSTR.2018.08.001662Biomedical Journal of Scientific & Technical Research.

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Blob Case History-The Control of Impurities-A Critical Is...

Created: 2018-08-01 05:40:18

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Case History-The Control of Impurities-A CriticalIssue to The Active Pharmaceutical Ingredient 

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Blob Case History-The Control of Impurities-A Critical Is...

Created: 2018-08-01 05:35:55

Credits: User Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Case History-The Control of Impurities-A CriticalIssue to The Active Pharmaceutical Ingredient 

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4367?size=60x60 Ve William Senior
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Blob Distribución de metales pesados en sedimentos superf...

Created: 2018-07-29 18:42:42

Credits: User William Senior

License: Creative Commons Attribution-Share Alike 3.0 Unported License

La concentración total y las formas químicas de los metales pesados se determinaron en sedimentossuperficiales del Orinoco Medio, Venezuela, utilizando una solución 25% (v/v) de acidoacético/solución HNO3: HCl: HClO4 (3:2:1), espectrofotometría de absorción atómica con llama ytécnica de vapor en frio. El rango de los valores totales variaron entre 8871 a 116.759 μgFeg-1,102,45 a 469,44 μgMn g-1; 0,93 a 17,64 μgCu g-1; 4,4...

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4367?size=60x60 Ve William Senior
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Blob DISTRIBUCIÓN Y ESPECIACIÓN DE ALGUNOS METALES PESADO...

Created: 2018-07-29 18:31:20

Credits: User William Senior

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Se evaluó la distribución y especiación de los metales pesados Cd, Ni, Mn y Cu en sedimentos superficiales de tres áreas geográficas del oriente del país ubicadas en la Bahía de Guanta-Pertigalete, estado Anzoátegui, Venezuela. Las muestras fueron recolectadas utilizando una draga Diez Laffont de 0,02 m2 de área. Los sedimentos fueron sometidos a un proceso de extracción por pasos para extraer las diferentes fracciones geoq...

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4367?size=60x60 Ve William Senior
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Blob DESCRIPCIÓN DE LAS CARACTERÍSTICAS FISICOQUÍMICAS DE...

Created: 2018-07-29 18:26:25

Credits: User William Senior

License: Creative Commons Attribution-Share Alike 3.0 Unported License

En Venezuela los estudios limnológicos en los grandes ríos como el Apure, el niño es debido a la complejidad de la logística sobre todo, para la captación de las muestras. En esta investigación se determinaron algunos parámetrosfisicoquímicos (nivel del río, conductividad, temperatura, pH, Oxígeno disuelto, Material en suspensión, turbidez, transparenciadel agua, nitrógeno total, nitrato, nitrito, amonio, f&oa...

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4367?size=60x60 Ve William Senior
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Blob Estudio de la degradación de la materia orgánica en ...

Created: 2018-07-29 18:21:47

Credits: User William Senior

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Una muestra de agua colectada en el estuario de l´ Elorn (Brest-Francia), fue incubada durante 118 días en la oscuridad a temperatura ambiente 

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4367?size=60x60 Ve William Senior
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Blob Analyse des sucres par chromatographie liquide de ha...

Created: 2018-07-29 17:55:30 | Last updated: 2018-07-29 18:06:16

Credits: User William Senior

License: Creative Commons Attribution-Share Alike 3.0 Unported License

L´eau de mer contient en différents proportions les composés organiques les plus diverses.

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4367?size=60x60 Ve William Senior
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Blob Corrientes superficiales en la Bahía de Bergantín (E...

Created: 2018-07-29 17:43:19

Credits: User William Senior

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Un conjunto de observaciones de corrientes superficiales realizadas por el Instituto Oceanográficode Venezuela en la Bahía de Bergantín, se obtuvieron durante algunos meses de1989. Ese conjunto de mediciones se analiza a la luz de nuevas metodologías; en particular sedescribe y analiza la naturaleza del registro de corriente y su posible vinculación con agentesforzantes. Se encuentra que: a) Opuesto a la creencia generalizada de que la bahía de Bergan...

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4367?size=60x60 Ve William Senior
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Blob CONTENIDO DE GRASA Y PROTEINA EN Pygocentrus cariba,...

Created: 2018-07-29 16:16:43

Credits: User William Senior

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Se determinó la concentración de grasa y proteína en el tejido muscular de 40 peces de cada una de las especies Pygocentrus cariba, Prochilodus mariae, Plagioscion squamosissimus, Piaractus brachypomus e Hypostomus plecostomus,capturados en una laguna de inundación del rio Orinoco medio utilizando redes de enmalle. Los contenidos de proteína y grasa se determinaron por los métodos de la Asociación de Químico...

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4367?size=60x60 Ve William Senior
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Blob Concentration of K, Na, Ca, Mg, Fe, proteins and fat...

Created: 2018-07-29 16:08:23

Credits: User William Senior

License: Creative Commons Attribution-Share Alike 3.0 Unported License

An analysis of the concentratlons of potassiurn, sodium. calcium. magnesiurn. tron, proteíns and fat, was made in the muscular tissue of the líned catftsh PseUliop laiystomajasciatLtm from the middle Orlnoco ínVenezuela, as a contribu tlon to the knowledge ofthe ecofisiology ofthe species and ofits importance from the nutritious point ofview. The salts were analyzed by Espectrofotometria ofAtomic AbsorpUon with fIame of air-acetylene and correction ofdeuterium bottom, usi...

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4367?size=60x60 Ve William Senior
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Blob Concentraciones y comportamiento de metales pesados ...

Created: 2018-07-29 15:48:18

Credits: User William Senior

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Existe una amplia gamade productos derivadosde las actividades humanasque, una vez vertidos a los ríos, costasy estuarios, causan alteraciones ecológicasespecificas. Tal es el caso de losmetales pesados. El Grupo de ExpertosSobre Aspectos Científicos de ContaminaciónMarina (GESAM) advierte sobrela imperativa y urgente necesidad decrear programas de seguimiento continuoen los ríos, estuarios y zonas costeras,para obtener información que permita dise&nt...

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