Q16:Targets in Parkinson's disease or Alzheimer's disease are activated by which compounds? and Q20: For a given disease, retrieve all targets in the pathway and all active compounds hitting them.

In the Open PHACTS project, we have developed KNIME utility nodes that can be set to automatically leverage the desired content from Open PHACTS web services and simplify the construction of workflow processes.  In this workflow we use the these KNIME nodes (which can be down loaded here: https://github.com/openphacts/OPS-Knime ) with the Open PHACTS API call Target for Disease followed by Target Pharmacology with filter minEx-pChembl=5 to answer scientific competency question Q16:Targets in Parkinson's disease or Alzheimer's disease are activated by which compounds? and Q20: For a given disease, retrieve all targets in the pathway and all active compounds hitting them.