ADR_substantiationatc00Workflow ATC input
The 7 digit atc code of a drug 2011-02-08 18:29:15.460 CETM01AH012010-07-19 13:19:34.980 CESTThe drug input.
The ATC code of a drug (5th level, 7 digits)2011-03-11 18:08:12.304 CET2011-03-20 11:53:55.666 CETWorkflow drug input
The ACT code of a drug (5th level, 7 digits)2011-03-11 17:43:54.128 CETWorkflow ATC input 2010-07-19 13:19:29.11 CESTN05AD012011-03-20 11:54:15.83 CETevent00Workflow clinical event input
Allowed events are:
For the clinical events, the following input types are allowed:
1) UMLS CUI concept identifiers (single identifier or a list of identifiers)
2) clinical events observed as adverse drug reactions according to the EU-ADR project (see ref for details) 2011-03-11 17:47:43.212 CET2011-03-20 12:41:32.610 CETThe clinical event input
For the clinical events, the following input types are allowed:
1) UMLS: UMLS CUI concept identifiers
2) EUADR_EVENT: clinical events observed as adverse drug reactions according to the EU-ADR project (see ref for details)
If you use option 1), insert here a single UMLS CUI identifier or a list of identifiers.
If you use option 2), insert here the name of the EUADR_EVENT as defined in ref. 2011-04-15 09:57:26.992 CESTWorkflow clinical event input
Allowed events are:
For the clinical events, the following input types are allowed:
1) UMLS: UMLS CUI concept identifiers
2) EUADR_event: clinical events observed as adverse drug reactions according to the EU-ADR project (see ref for details)
If you use option 1), insert here a single UMLS CUI identifier or a list of identifiers.
If you use option 2), insert here the name of the EUADR_event as defined in ref. 2011-03-11 17:53:02.632 CETThe clinical event input
For the clinical events, the following input types are allowed:
1) UMLS: UMLS concept identifiers
2) EUADR_EVENT: clinical events observed as adverse drug reactions according to the EU-ADR project (see ref for details)
If you use option 1), insert here a single UMLS concept identifier or a list of identifiers.
If you use option 2), insert here the name of the EUADR_EVENT as defined in http://ibi.imim.es/ADR_Substantiation.html. 2011-07-29 15:57:36.998 CESTThe clinical event input
For the clinical events, the following input types are allowed:
1) UMLS: UMLS concept identifiers
2) EUADR_EVENT: clinical events observed as adverse drug reactions according to the EU-ADR project (see http://ibi.imim.es/ADR_Substantiation.html for details).
If you use option 1), insert here a single UMLS concept identifier or a list of identifiers.
If you use option 2), insert here the name of the EUADR_EVENT as defined in http://ibi.imim.es/ADR_Substantiation.html. 2011-07-29 16:38:28.536 CESTC0003811
C0023976
C0035828
C0040479
C15637152011-03-11 17:45:20.320 CETWorkflow event input
Allowed events are:
1) events of type EUADR_EVENT as defined in the EUADR project
2) events of type UMLS being a CUI concept identifier 2011-02-08 18:30:19.406 CETThe clinical event input
For the clinical events, the following input types are allowed:
1) UMLS: UMLS concept identifiers
2) EUADR_EVENT: clinical events observed as adverse drug reactions according to the EU-ADR project (see ref for details)
If you use option 1), insert here a single UMLS concept identifier or a list of identifiers.
If you use option 2), insert here the name of the EUADR_EVENT as defined in . 2011-07-29 15:56:51.84 CESTC0003811
C0023976
C0035828
C0040479
C1563715
C1832916
C1833154
C1835325
C1859062
C1859063
C1860467
C1863518
C1863519
C1867899
C1867904
C1970119
C2678483
C2678484
C26784852011-03-20 12:41:53.377 CETUGIB2010-09-30 17:56:42.141 CESTWorkflow clinical event input
Allowed events are:
1) events of type EUADR_EVENT as defined in the EUADR project
2) events of type UMLS being a CUI concept identifier 2011-03-11 17:44:51.984 CETThe clinical event input
For the clinical events, the following input types are allowed:
1) UMLS: UMLS CUI concept identifiers
2) EUADR_event: clinical events observed as adverse drug reactions according to the EU-ADR project (see ref for details)
If you use option 1), insert here a single UMLS CUI identifier or a list of identifiers.
If you use option 2), insert here the name of the EUADR_event as defined in ref. 2011-03-11 18:08:40.212 CET2011-02-08 18:29:52.77 CETName of the event. This is only required for user-friendly visualization of the results. In particular, if the input is a CUI concept identifier. 2011-02-08 18:29:49.59 CETWorkflow event input 2010-09-30 17:56:35.723 CEST2011-03-11 17:44:58.278 CETeventType00Type of the event to be processed.
For the clinical events, the following types are allowed:
1) UMLS: if you use UMLS CUI concept identifiers (single identifier or a list of identifiers)
2) EUADR_EVENT: if you use clinical events as defined in the EU-ADR project
2011-04-15 09:56:27.129 CESTdefault = EUADR_EVENT2011-02-08 18:30:38.742 CETEUADR_EVENT2011-02-08 18:30:43.830 CETType of the event to be processed.
Must be either EUADR_EVENT if the event is defined in the EUADR project or UMLS if the event is a list of CUI concept identifiers
2011-02-08 18:30:37.869 CETType of the event to be processed.
Must be either EUADR_EVENT if the event is defined in the EUADR project or UMLS if the event is a list of CUI concept identifiers2011-01-24 17:29:31.677 CETType of the event to be processed.
For the clinical events, the following types are allowed:
1) UMLS: if you use UMLS CUI concept identifiers (single identifier or a list of identifiers)
2) EUADR_event: if you use clinical events as defined in the EU-ADR project
2011-03-11 17:50:26.85 CETUMLS2011-03-11 17:50:35.904 CETType of the event to be processed.
For the clinical events, the following types are allowed:
1) UMLS: if you use UMLS concept identifiers (single identifier or a list of identifiers)
2) EUADR_EVENT: if you use clinical events as defined in the EU-ADR project (see http://ibi.imim.es/ADR_Substantiation.html)
2011-07-29 15:58:38.772 CESTcytoscape00Insert here the path to your local cytoscape installation.
2011-03-11 17:44:28.744 CETinsert here the path to your local cytoscape installation e.g. /home/user/cytoscape-v2.7.0/2011-01-10 12:49:09.100 CET/home/user/cytoscape-v2.7.02011-01-10 12:46:23.859 CETcytoscape-v2.7.02011-01-10 12:46:17.448 CETinsert here the path to your local cytoscape installation e.g. /home/user/cytoscape2011-01-10 12:45:49.862 CETinsert here the path to your local cytoscape installation e.g. /home/user/cytoscape-v2.7.02011-01-10 12:46:10.80 CET/home/user/Cytoscape_v2.7.0/2011-07-29 15:55:51.933 CESTInsert here the path to your local cytoscape installation e.g. /home/user/cytoscape-v2.7.0/
2011-02-08 18:34:26.347 CETInsert here the path to your local Cytoscape installation.
2011-03-11 18:10:06.24 CET/home/user/cytoscape-v2.7.0/2011-01-10 12:49:14.15 CETeventName00Acute liver injury2011-03-11 17:54:30.364 CETName of the event. This is only required for user-friendly visualization of the results. In particular, if the input is a CUI concept identifier. 2011-02-08 18:29:57.540 CETUGIB2011-02-08 18:30:03.21 CETLong QT syndrome2011-03-20 11:54:37.770 CETDefine a name for the clinical event.
This is required for user-friendly visualization of the results. 2011-07-29 15:58:01.879 CESTDefine a name for the clinical event.
This is only required for user-friendly visualization of the results. 2011-03-11 17:54:14.812 CETdrugTargetsOutputFull XML output for the get drug targets web service.2010-07-19 13:17:52.912 CESTFull XML output for the getDrugTargets web service.2011-02-08 18:32:03.919 CETXML output file for the getDrugTargets web service.2011-03-11 18:00:23.225 CETdrugEventLinkingPathwaysList of biological pathways in which both proteins associated to the clinical event and to the drug are present. 2011-03-11 18:01:21.856 CETList of pathways in which at least one event and one drug protein are expressed.2011-02-08 18:32:52.619 CETList of biological pathways that link the drug with the event. In each pathway contain proteins that are associated to the clinical event and to the drug. 2011-07-29 16:01:07.332 CESTeventProteinsOutputFull XML output for the get Disease Associated genes web service.2010-07-19 13:19:17.699 CESTFull XML output for the getDiseaseAssociatedProteins web service.2011-02-08 18:31:39.335 CETXML output file for the getDiseaseAssociatedProteins web service.2011-03-11 18:00:03.328 CETdrugEventLinkingProteinsList of proteins that link the drug and the event. They represent the intersection between the Drug-Tarhresult from the intersection of the set of proteins annotated to the drug and the set of proteins annotated to the clinical event. 2011-07-29 16:02:08.860 CESTList of proteins annotated to both the clinical event and the drug.2011-03-11 18:01:52.232 CETList of proteins annotated to both, event and drug.2011-02-08 18:33:19.929 CETList of proteins that link the drug and the event. They represent the intersection between the Drug-Target-Profile and the Event-Protein-Profile.2011-07-29 16:02:54.840 CESTList of proteins that result from the intersection of the set of proteins annotated to the drug and the set of proteins annotated to the clinical event. 2011-03-11 18:02:50.105 CETCytoscapeResultGraphNetwork file that can be visualized in Cytoscape. Simply save this file using the file extension .xgmml and open it in Cytoscape. It contains a multipartite graph in which the nodes are the drug, the clinical event and the proteins and the associations between them.2011-07-29 15:59:11.272 CESTNetwork file that which can be visualized in Cytoscape. Simply store this file using the file extension .xgmml and open it in Cytoscape. It contains a multipartite graph in which the nodes are the drug, the clinical event and the proteins and the associations between them.2011-03-11 17:58:45.680 CETNetwork file that which can be visualized in Cytoscape. Simply save this file using the file extension .xgmml and open it in Cytoscape. It contains a multipartite graph in which the nodes are the drug, the clinical event and the proteins and the associations between them.2011-03-11 17:59:13.504 CETCytoscape graph which can be openend in Cytoscape. Simply store this file using the file ending .xgmml and open it in Cytoscape. It contains the drug, event and their annotated proteins as well as supporting information such as link outs to publications etc.2011-02-08 18:31:18.807 CETeventProteinsList of proteins annotated to the clinical event.2011-03-11 17:59:43.88 CETList of all proteins annoated to the event.2011-02-08 18:31:29.111 CETdrugTargetsList of proteins annotated to the drug.2011-02-08 18:31:51.496 CETCreateDiseaseProteinListstring0concatenated00fail00net.sf.taverna.t2.activitieslocalworker-activity1.2net.sf.taverna.t2.activities.localworker.LocalworkerActivityorg.embl.ebi.escience.scuflworkers.java.StringListMergeworkflowjava.lang.Stringtruestring0l('text/plain')0concatenated00fail0UserNameHere2011-01-27 12:48:28.442 CETUserNameHere2011-01-27 12:54:47.847 CETUserNameHere2011-01-27 12:58:24.852 CETUserNameHere2011-01-27 14:01:57.290 CETUserNameHere2011-01-27 12:48:44.599 CETUserNameHere2011-03-16 11:53:10.628 CETUserNameHere2011-02-10 11:26:20.837 CETUserNameHere2011-02-10 11:14:16.435 CETUserNameHere2011-03-16 12:43:37.265 CETUserNameHere2011-03-16 12:34:50.409 CETnet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Parallelize1net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.ErrorBouncenet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Failovernet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Retry1.0100050000net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.InvokegenerateProteinListseventProteins0drugProteins0output00net.sf.taverna.t2.activitieswsdl-activity1.2net.sf.taverna.t2.activities.wsdl.xmlsplitter.XMLInputSplitterActivity<s:extensions xmlns:s="http://org.embl.ebi.escience/xscufl/0.1alpha"><s:complextype optional="false" unbounded="false" typename="proteinLists" name="proteinLists" qname="{http://service.adrPath.ibi.imim.es/xsd}proteinLists"><s:elements><s:basetype optional="false" unbounded="false" typename="string" name="eventProteins" qname="{http://service.adrPath.ibi.imim.es/xsd}>proteinLists>eventProteins" /><s:basetype optional="false" unbounded="false" typename="string" name="drugProteins" qname="{http://service.adrPath.ibi.imim.es/xsd}>proteinLists>drugProteins" /></s:elements></s:complextype></s:extensions>falseeventProteins0'text/plain'falsedrugProteins0'text/plain'0output0'text/xml'net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Parallelize1net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.ErrorBouncenet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Failovernet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Retry1.0100050000net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.InvokeConvertToHTMLatc0intersectingPathways0event0EUADR_intersectingPathways00net.sf.taverna.t2.activitieslocalworker-activity1.2net.sf.taverna.t2.activities.localworker.LocalworkerActivitynet.sourceforge.taverna.scuflworkers.xml.XSLTWorkerworkflowjava.lang.StringtrueintersectingPathways0text/plainjava.lang.Stringtrueatc0text/plainjava.lang.Stringtrueevent0text/plain0EUADR_intersectingPathways0UserNameHere2011-02-08 14:46:35.637 CETUserNameHere2011-01-10 14:35:06.569 CETUserNameHere2011-01-04 17:28:55.745 CETUserNameHere2011-01-07 11:05:44.551 CETUserNameHere2011-01-07 13:02:47.919 CETUserNameHere2011-01-24 14:12:31.876 CETUserNameHere2011-01-07 13:13:55.151 CETUserNameHere2011-01-07 11:00:56.265 CETUserNameHere2011-01-07 17:01:44.948 CETUserNameHere2011-01-07 10:59:55.696 CETUserNameHere2011-01-07 11:04:06.140 CETUserNameHere2011-01-07 17:03:53.968 CETUserNameHere2011-01-07 15:28:56.549 CETUserNameHere2011-01-04 17:35:25.767 CETUserNameHere2011-02-11 17:38:06.464 CETUserNameHere2011-01-07 13:00:00.84 CETUserNameHere2011-03-16 13:02:19.820 CETUserNameHere2011-03-16 12:50:45.227 CETUserNameHere2011-02-08 14:40:17.130 CETUserNameHere2011-01-07 11:06:39.488 CETUserNameHere2011-02-11 17:30:33.232 CETUserNameHere2011-04-15 13:31:55.549 CESTUserNameHere2011-02-07 16:04:18.641 CETUserNameHere2011-02-11 17:33:40.687 CETUserNameHere2011-01-07 15:23:03.842 CETUserNameHere2011-02-08 15:12:04.667 CETUserNameHere2011-01-07 13:11:13.115 CETUserNameHere2011-01-10 12:48:57.256 CETUserNameHere2011-01-07 12:39:33.114 CETUserNameHere2011-02-07 16:15:40.765 CETUserNameHere2011-01-10 10:27:03.462 CETUserNameHere2011-01-07 12:32:23.168 CETUserNameHere2011-01-07 10:59:16.782 CETUserNameHere2011-02-09 11:13:41.230 CETUserNameHere2011-01-07 12:59:20.325 CETUserNameHere2011-03-16 16:27:06.962 CETUserNameHere2011-01-07 13:08:28.15 CETUserNameHere2011-03-16 12:47:51.603 CETUserNameHere2011-03-16 16:07:59.755 CETUserNameHere2011-01-21 14:43:38.627 CETUserNameHere2011-04-18 17:32:02.605 CESTUserNameHere2011-02-11 17:24:18.555 CETUserNameHere2011-01-07 13:11:29.19 CETUserNameHere2011-01-24 14:12:54.675 CETUserNameHere2011-01-10 12:42:11.271 CETUserNameHere2011-01-07 15:19:59.88 CETUserNameHere2011-02-11 17:28:36.0 CETUserNameHere2011-01-04 17:41:26.968 CETUserNameHere2011-01-04 17:42:55.522 CETUserNameHere2011-01-07 13:15:44.385 CETUserNameHere2011-01-07 12:35:20.444 CETUserNameHere2011-02-11 17:25:04.791 CETnet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Parallelize1net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.ErrorBouncenet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Failovernet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Retry1.0100050000net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.InvokeCheckConnectingPathwaysintersectionList1failDisease0failDrug0result00net.sf.taverna.t2.activitiesbeanshell-activity1.2net.sf.taverna.t2.activities.beanshell.BeanshellActivityworkflowjava.lang.StringtrueintersectionList1text/plainjava.lang.StringtruefailDisease0text/plainjava.lang.StringtruefailDrug0text/plain0result0net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Parallelize1net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.ErrorBouncenet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Failovernet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Retry1.0100050000net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.InvokeXPath_getPathwaysxpath0xml-text0nodelist11net.sf.taverna.t2.activitieslocalworker-activity1.2net.sf.taverna.t2.activities.localworker.LocalworkerActivitynet.sourceforge.taverna.scuflworkers.xml.XPathTextWorkerdom4j:dom4j:1.6workflowdom4jdom4j1.6716010169java.lang.Stringtruexpath0'text/plain'java.lang.Stringtruexml-text0'text/xml'1nodelist1l('text/plain')1nodelistAsXML1l('text/plain')net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Parallelize1net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.ErrorBouncenet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Failovernet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Retry1.0100050000net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Invokexpath_valuevalue00net.sf.taverna.t2.activitiesstringconstant-activity1.2net.sf.taverna.t2.activities.stringconstant.StringConstantActivity//ns3:pathway/ns3:namenet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Parallelize1net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.ErrorBouncenet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Failovernet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Retry1.0100050000net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.InvokeTellResultmessage0net.sf.taverna.t2.activitieslocalworker-activity1.2net.sf.taverna.t2.activities.localworker.LocalworkerActivitynet.sourceforge.taverna.scuflworkers.ui.TellWorkerworkflowjava.lang.Stringtruemessage0'text/plain'0answer0UserNameHere2011-03-16 12:02:48.666 CETnet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Parallelize1net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.ErrorBouncenet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Failovernet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Retry1.0100050000net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.InvokeADR_substantiation_through_proteinsatc0eventType0event0eventName0cytoscape0drugTargetsOutput00diseaseProteinsOutput00CytoscapeResultGraph00diseaseProteins00drugTargets00connectingProteins00net.sf.taverna.t2.activitiesdataflow-activity1.2net.sf.taverna.t2.activities.dataflow.DataflowActivitynet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Parallelize1net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.ErrorBouncenet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Failovernet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Retry1.0100050000net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.InvokeCreateDrugTargetListstring0concatenated00fail00net.sf.taverna.t2.activitieslocalworker-activity1.2net.sf.taverna.t2.activities.localworker.LocalworkerActivityorg.embl.ebi.escience.scuflworkers.java.StringListMergeworkflowjava.lang.Stringtruestring0l('text/plain')0concatenated00fail0UserNameHere2011-01-27 12:48:44.599 CETUserNameHere2011-01-27 12:54:47.847 CETUserNameHere2011-03-16 11:56:59.109 CETUserNameHere2011-03-16 12:35:02.385 CETUserNameHere2011-02-10 11:14:16.435 CETUserNameHere2011-02-10 11:26:20.837 CETUserNameHere2011-01-27 12:48:28.442 CETUserNameHere2011-01-27 12:58:24.852 CETUserNameHere2011-01-27 14:01:57.290 CETUserNameHere2011-03-16 12:43:23.121 CETnet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Parallelize1net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.ErrorBouncenet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Failovernet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Retry1.0100050000net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.InvokegetPathwaysproteinLists0intersectingPathways00net.sf.taverna.t2.activitieswsdl-activity1.2net.sf.taverna.t2.activities.wsdl.WSDLActivityhttp://ibi.imim.es/axis2/services/AdrPathService?wsdlgetPathwaysnet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Parallelize1net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.ErrorBouncenet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Failovernet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Retry1.0100050000net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.InvokeCreateDiseaseProteinListstringgenerateProteinListseventProteinsgenerateProteinListsdrugProteinsConvertToHTMLatcConvertToHTMLintersectingPathwaysConvertToHTMLeventCheckConnectingPathwaysintersectionListCheckConnectingPathwaysfailDiseaseCheckConnectingPathwaysfailDrugXPath_getPathwaysxpathXPath_getPathwaysxml-textTellResultmessageADR_substantiation_through_proteinsatcADR_substantiation_through_proteinseventTypeADR_substantiation_through_proteinseventADR_substantiation_through_proteinseventNameADR_substantiation_through_proteinscytoscapeCreateDrugTargetListstringgetPathwaysproteinListsdrugTargetsOutputdrugEventLinkingPathwayseventProteinsOutputdrugEventLinkingProteinsCytoscapeResultGrapheventProteinsdrugTargetsd471959c-29f3-49f6-bda2-5eaec8dd5ea82011-01-17 11:45:21.958 CET32656a2e-ee50-4835-b479-aabc4396016f2011-01-04 13:57:15.461 CET653e4e25-055c-4379-9a83-2d1151d8478a2011-01-14 18:14:09.85 CET0ed622c5-32b6-4791-be7a-382da065f0862010-12-20 16:03:47.872 CET3f105056-fcab-4bc4-8cf8-9951729b24df2011-01-04 12:17:29.826 CET92b74c17-96d8-4934-8e8e-7a0a6e57cacc2011-03-15 13:47:22.775 CET8b7cf829-7859-420c-b9c8-01f98b083d362011-01-13 14:32:57.871 CETfddb1035-bbbc-4bf5-bef4-17698d5fc1632011-01-24 17:17:23.149 CETcd0ec09d-4927-4e35-b871-c15f973ff63c2011-07-29 16:01:09.361 CESTADR_substantiaion2011-03-03 17:19:02.318 CETf9ba5ab6-b688-47c5-b42a-043bc783a51e2011-03-20 12:41:58.64 CETdeb58f7d-9e66-44bb-b930-e5e49ea313cb2010-12-20 15:29:06.561 CETec1b8920-e38e-4fdf-810a-a2cadf481d9e2011-04-15 13:32:07.580 CESTfee13559-e86b-4418-9599-f2a1d6446c752011-01-13 16:50:29.626 CETf2c45435-2f63-4179-879b-323954bcd7732011-01-17 12:51:01.494 CET9bbca5ad-5e2b-4342-981e-bdbbca78905f2011-03-16 16:21:58.324 CETf9662ff3-5ad3-42ec-8930-68c628fd65022010-09-17 10:42:02.441 CESTe8d8164d-cf5a-43ae-8ca6-18becacf8d8b2011-01-07 12:41:50.692 CETa58cc5d7-34ff-4249-847b-e7ac528a8b492011-02-11 17:55:26.353 CETcb84c608-6105-4b6b-9bb7-77acb56389ed2010-09-17 10:52:24.545 CEST7ab44917-a605-40c4-912d-ad115f75a3152011-03-15 13:33:48.229 CETcba4e9b3-6dcb-4e2f-9ebe-08f42ed5bc382011-01-17 12:49:37.448 CET37a82b12-5862-4b63-8ad6-aee20e96ba262011-03-15 13:38:22.610 CET65e8de2b-f546-489c-a7b3-34e10fceadd42011-02-08 18:08:31.364 CET88f58e58-6f9f-41fa-ac5c-2a24e20ed1ab2011-02-08 17:23:11.786 CET9d1b78c8-5d43-43cd-9e41-2c0d262901192011-01-17 10:57:16.237 CET93d045f8-5566-400e-b931-2aca1f9b39472011-01-13 16:28:44.447 CETce078332-d129-49d8-ac85-90387bfa67e32011-03-11 17:44:02.127 CET554c0775-68cf-419c-8202-2f1baa1a9dca2011-01-04 12:04:35.852 CETcc772697-d010-4057-b756-36c08166d6452011-01-17 10:35:59.185 CETd7824096-eb0c-4fb9-87f5-0341596b52112010-09-17 10:48:39.9 CESTb66fe7cc-39dc-4949-afc0-83c195751d592011-01-04 17:36:27.395 CET7a5af348-2104-49b8-b448-abf464cfa93a2011-03-20 11:54:42.966 CETThis workflow substantiates drug safety signals composed of a drug and an adverse reaction.
In more detail, the workflow tries to find feasible paths connecting the drug and the event.
First, it checks if there are proteins that are annotated to a given adverse event and at the same time target of the given drug. (NESTED WORKFLOW ADR_substantiation_through_proteins)
Second, it tries to connect drug and event through biological pathways. Here, it checks if there are proteins from drug and event side which are expressed in the same tissue and also annotated to the same biological pathway.
As adverse event, the following event types are allowed:
1) events as defined in the EU-ADR project such as UGIB
2) UMLS CUI concept identifiers
As drug input 7 digit drug ATC codes are allowed.
As result a list of intersecting proteins as well as a list of pathways is provided.
If any of the two lists is not empty, the drug-event pair is substantiated as drug safety signal.
For the intersecting proteins, a Cytoscape graph is generated for user-friendly visualization. It contains the event, drug and their annotated proteins as well as additional information such as links to publications etc.
For the intersecting pathways a html page summarizing the results is generated.
2011-03-11 17:13:02.710 CET3149dbd1-5026-465e-a23d-1e84cd2dd4382011-03-16 12:03:06.361 CETAnna Bauer-Mehren
Integrative Biomedical Informatics Laboratory (GRIB, IMIM/UPF)2011-02-08 18:01:15.677 CETff1f9074-7f1b-4f04-b09b-25e8d10759332011-01-17 11:08:52.797 CETADR_substantiation2011-03-10 11:38:43.750 CETe3312a5d-b3fc-4959-8201-679ca1cfe8c92011-03-16 12:13:58.439 CETe57ad22d-32f9-4fc7-80d1-9186a849119b2011-01-07 15:27:40.662 CETf5f7d39a-e76c-4988-88a4-7d9e61f3b1162011-01-04 12:59:27.437 CET06b488ab-b4b6-4fdf-bf4e-557d1d5b0d2c2011-01-04 16:21:31.258 CETe763f27d-93a2-4058-a2eb-4020c8773e5d2011-02-08 17:30:54.650 CET04df6bef-43a4-47c9-ab71-d835f232f82a2011-03-16 12:35:06.863 CETAnna2010-07-19 13:20:04.607 CEST294b7d82-741e-4050-aabf-d92c099dcb762011-03-16 12:47:56.775 CET2f799556-78fe-4d91-a0b9-989191ba37032011-01-13 16:39:50.188 CETa59568bd-3909-4380-a924-be18570272b52011-01-04 13:46:26.232 CETThe signal substantiation workflow seeks to establish a connection between the clinical event and the drug through different paths:
(i) through proteins in common among the proteins that are drug targets or metabolite targets and proteins associated to the clinical event
(ii) through proteins that are drug targets or metabolite targets and proteins associated to the clinical event that participate in a common biological pathway.
The workflow proceeds as follows:
First, it checks if there are proteins that are annotated both to the clinical event and to the drug (NESTED WORKFLOW ADR_substantiation_through_proteins).
Second, it looks for connections between the drug and the clinical event through biological pathways. Information about tissue expression of the proteins is used to filter the results.
Input of the workflow:
The input of the workflow is a drug-event pair.
For the clinical events, the following types are allowed:
1) UMLS concept identifiers (UMLS CUI)
2) clinical events observed as adverse drug reactions according to the EU-ADR project (see http://ibi.imim.es/ADR_Substantiation.html for details)
For the drug, a ATC code (5th level, seven digits) is required. NOTE: only one ATC code can be processed at a time
Output of the workflow:
1) List of Drug-Event-Liniking proteins:
The results can be visualized as a network using Cytoscape. The network is a multi-partite graph, in which the nodes are the event, the drug and the proteins, and the edges the associations between these nodes. In addition, all the evidences supporting the associations can be explored in the graph representation.
2)List of pathways:
The results of the analysis through biological pathways is summarized in an html file.2011-07-29 15:34:40.219 CEST667271d2-597d-4625-91ce-d075886b89de2011-01-04 13:51:48.724 CET7d489ce0-6ed6-43d3-97fa-45fd176e818a2010-09-30 17:57:08.458 CEST66675211-5a30-4208-84ff-ff88264c56fd2011-07-29 16:04:45.403 CEST3037af44-07cf-46e1-ac3c-b91eafa75d742011-02-08 15:37:33.999 CET7aa10c7d-6fe1-4b77-8808-7cffa61ae3db2010-09-14 15:35:08.242 CEST497d97fc-2cb4-499c-a839-51809a6b46542011-01-19 17:30:01.794 CET0ea7d095-fc78-475b-9a96-efc6e41811dc2011-01-04 15:43:14.845 CET5c5101bf-6e14-400c-bcd6-66a7b4f6094b2011-01-19 17:33:29.326 CET8038ad73-2341-401f-9a99-1c9f30862a902011-01-07 11:04:15.227 CETe9ff23a5-0a75-45a8-80da-04db20f6e5012011-04-15 09:57:29.858 CEST2362930f-4165-4040-ae48-972079c15b992011-01-04 14:00:35.449 CET6da62234-8122-49b8-84db-05d8fc69a0e22011-03-11 17:13:18.332 CETa4d41213-eac5-4218-9657-d335797ee6242011-02-10 10:57:23.543 CET3eefa652-556b-4bdb-8571-8916193fa47d2011-02-11 17:20:11.19 CET250f91b2-afa1-4bae-845a-a24cfb89a9bb2011-02-11 17:43:44.119 CET656f5a21-7dc4-4e46-a6e4-67fd197decfe2011-01-14 18:08:30.745 CET7b7bf9ce-5249-4ad0-af27-ef7987d5c0512011-01-07 11:01:45.884 CETcbdfc13f-df16-4965-bc74-605d26c7d03f2011-01-13 12:51:13.433 CET90f41a2a-76c8-4de1-bdac-70a267ce9c3b2011-03-15 13:33:13.917 CET984a9292-80d5-4a03-bf77-cec858d566b32011-01-04 17:45:55.665 CET2986cd93-b5b6-4d68-95ba-6d2e4863fbdd2011-07-29 15:57:37.509 CEST88fc305d-6670-4094-af52-29a51219a9052011-02-04 15:35:17.39 CETbaf8876d-4848-4588-a2bd-f5945bcd74672011-07-29 13:23:01.362 CEST0ae6554a-e8e6-45ce-b37d-b9cbfe1f7a7e2011-01-27 14:19:55.221 CET0db3f322-5f1f-4505-bf6a-85c5a9eeb2892011-01-04 12:48:54.533 CETADR substantiation2011-07-29 15:36:17.466 CEST15d43d13-40f2-4306-b952-02c102c5c8672011-01-27 14:41:42.46 CETThe signal substantiation workflow seeks to establish a connection between the clinical event and the drug through different paths:
(i) through proteins in common between the drug-target
(ii) through proteins that are drug targets or metabolite targets and proteins associated to the clinical event that participate in a common biological pathway.
The workflow proceeds as follows:
First, it checks if there are proteins that are annotated both to the clinical event and to the drug (NESTED WORKFLOW ADR_substantiation_through_proteins).
Second, it looks for connections between the drug and the clinical event through biological pathways. Information about tissue expression of the proteins is used to filter the results.
Input of the workflow:
The input of the workflow is a drug-event pair.
For the clinical events, the following types are allowed:
1) UMLS concept identifiers (UMLS CUI), a single identifier of a list of identifiers are accepted.
2) clinical events observed as adverse drug reactions according to the EU-ADR project (see http://ibi.imim.es/ADR_Substantiation.html for details)
For the drug, a ATC code (5th level, seven digits) is required. NOTE: only one ATC code can be processed at a time.
Output of the workflow:
1) List of Drug-Event-Liniking proteins:
The results can be visualized as a network using Cytoscape. The network is a multi-partite graph, in which the nodes are the event, the drug and the proteins, and the edges the associations between these nodes. In addition, all the evidences supporting the associations can be explored in the graph representation.
2)List of pathways:
The results of the analysis through biological pathways is summarized in an html file.2011-07-29 15:38:46.311 CEST62ec5abb-7c12-4bb9-af57-456cbcbbda9e2011-01-10 12:42:16.19 CET31173be0-dbe9-4ece-b477-3693fa39a7ba2011-07-29 17:38:51.793 CEST04372b6f-fcc3-4b2c-83ac-b64512f59ce22010-09-17 10:39:50.849 CEST776ad2f6-e9ba-4c99-ad3a-772b5e9cb61b2010-12-21 15:39:22.876 CET65eb78b5-485d-4cd9-9a11-7bddd846bbb62011-03-15 13:48:23.665 CETf941ca21-1633-4f04-81ef-b9ba74c78a342011-01-10 14:36:36.252 CETc4308939-a661-4907-8606-1a86778d89472010-07-29 18:24:46.817 CEST15493c2e-a54c-493e-8898-710705b8c5d72010-09-08 16:38:16.856 CESTd19909e8-669b-4d65-9468-f760fd7fa7502011-01-07 17:04:00.846 CETf6450ab7-d5fe-4ae5-b7f0-36f7a29cb8b42011-01-04 12:52:56.78 CETcad732c9-8359-465b-ba8c-b93fd44bfa542011-01-13 16:49:14.442 CET5069111b-8740-4d87-8d97-67f945781f092011-01-27 14:12:18.422 CET882c06d0-a11e-4967-a338-a8c67dfa4fb42010-08-26 19:22:46.869 CEST935964c1-91b9-4e5f-9c32-ed5fccf9f9a22010-09-17 10:14:21.353 CEST6e32b8bb-01e4-4abc-a589-2577b16b8f9c2011-01-13 16:30:25.16 CET46641391-2e52-4d10-826a-e096b79bec402011-02-08 17:40:06.602 CETcf360835-3b60-421b-a4a3-ff67fffa4aaf2011-01-17 11:24:32.777 CET11a2dca5-f9cc-4121-ac2d-1da011bf6ad82011-01-04 16:15:49.408 CET218c5dcc-3492-4ba4-a473-9264f389058b2011-01-17 12:43:10.315 CET1897606e-1d7d-4c96-ab38-6ef1b9cf38ac2010-09-30 18:05:13.306 CEST55fe80fb-04d7-41e7-887b-51c79c87ac7e2011-02-11 17:28:44.612 CETcd50768e-3d13-410b-81bf-69a54a7ca1be2011-02-08 15:12:13.473 CET09b3d4f2-ac6b-49de-bc63-c4fc833798342010-09-08 15:39:11.360 CEST4f339317-dc4d-4151-8203-893f0e707b072011-01-07 15:23:18.432 CETdf0821cc-9125-4b9a-aa73-2211758720bb2011-02-08 17:49:18.886 CET5b108f21-e22f-4d6c-b3a2-280552f432962011-01-13 16:16:16.29 CETaf689045-45d3-4ca2-9e63-d833cdfd48032011-01-20 15:23:08.969 CETae92fb5d-fd57-4faa-ba70-55607ed783472011-01-17 12:38:05.300 CETaf060e60-6938-4295-8797-8c749b8d40852011-01-14 18:04:03.419 CETb80fba38-d085-4bef-924a-4178251076482011-01-04 15:49:32.364 CET2f700972-4f65-4993-9d83-d66122a575482011-01-13 16:13:22.795 CETa063837a-bf23-42da-8892-eb8044555c192010-09-30 18:08:32.887 CEST698f8dc5-519d-42cd-9017-b0e7d12ef34a2011-03-11 17:45:32.765 CET0c323d59-b2a3-48b4-b7e4-be31aff18c8a2011-02-08 17:55:36.60 CET53503b95-945b-46d3-8663-5b176536f52c2011-01-04 15:52:11.52 CET36bfcc9d-c7ca-4be8-9253-4ffbce3c3e352011-02-11 17:15:22.568 CETec258c77-f3a3-4657-9329-c820ab6870c62011-01-04 12:47:28.68 CET85a3ae41-67b5-45fa-820d-912538444b1a2011-01-13 12:45:21.974 CET383b1299-9c53-4115-9343-608a3398d6ed2011-03-16 16:27:15.122 CET9e00fd8b-8dec-498c-a0dc-59d56ba02dc22011-02-08 18:34:28.770 CETfa61c748-de3c-4438-ad8a-33dd39fcb76f2011-01-04 13:59:46.545 CET37c313f4-fc7f-44fb-b486-75344db8f9332011-01-13 15:50:00.475 CET46c1500c-4932-4c68-aa8d-86bb7861dc902011-03-16 11:55:44.735 CET72609134-3363-4249-8add-e098746061012011-01-07 13:00:06.54 CETb5507185-dd64-40aa-8e17-80cc8e6e5e862010-09-14 15:31:11.179 CEST9f6fca78-6d4d-4e62-90d4-2211905b83f12011-01-21 14:20:14.134 CET5f5a4dee-045f-4720-b990-9445ce4ce6272010-09-30 18:03:28.544 CESTThe signal substantiation workflow seeks to establish a connection between the clinical event and the drug through different paths:
(i) through proteins in common among the proteins that are drug targets or metabolite targets and proteins associated to the clinical event
(ii) through proteins that are drug targets or metabolite targets and proteins associated to the clinical event that participate in a common biological pathway.
The workflow proceeds as follows:
First, it checks if there are proteins that are annotated both to the clinical event and to the drug (NESTED WORKFLOW ADR_substantiation_through_proteins).
Second, it looks for connections between the drug and the clinical event through biological pathways. Information about tissue expression of the proteins is used to filter the results.
Input of the workflow:
The input of the workflow is a drug-event pair.
For the clinical events, the following types are allowed:
1) UMLS concept identifiers (UMLS CUI), a single identifier of a list of identifiers are accepted.
2) clinical events observed as adverse drug reactions according to the EU-ADR project (see http://ibi.imim.es/ADR_Substantiation.html for details)
For the drug, a ATC code (5th level, seven digits) is required. NOTE: only one ATC code can be processed at a time.
Output of the workflow:
1) List of Drug-Event-Liniking proteins:
The results can be visualized as a network using Cytoscape. The network is a multi-partite graph, in which the nodes are the event, the drug and the proteins, and the edges the associations between these nodes. In addition, all the evidences supporting the associations can be explored in the graph representation.
2)List of pathways:
The results of the analysis through biological pathways is summarized in an html file.2011-07-29 15:35:53.809 CEST0b1a7caa-589a-4fe2-a52c-3b0611d4abb52011-01-24 17:14:53.841 CET33baa09c-f0a1-42c7-add1-563f6b2541d22011-02-08 17:44:01.638 CET2b00853f-d2b9-4986-8085-fc3de81a76932010-09-08 17:25:02.20 CEST304ef1c5-fee1-4c6d-9d22-2b0a8b3285fc2011-01-17 12:50:25.677 CETde97e1d3-167f-4dae-917d-197e2e4b27b32010-09-30 18:00:40.4 CEST86ef6f43-c15f-4c2b-940a-1a73704cbaac2011-01-10 12:49:33.152 CETThe signal substantiation workflow seeks to establish a connection between the clinical event and the drug through different paths:
(i) through proteins in common among the proteins that are drug targets or metabolite targets and proteins associated to the clinical event
(ii) through proteins that are drug targets or metabolite targets and proteins associated to the clinical event that participate in a common biological pathway.
The workflow proceeds as follows:
First, it checks if there are proteins that are annotated both to the clinical event and to the drug (NESTED WORKFLOW ADR_substantiation_through_proteins)
Second, it looks for connections between the drug and the clinical event through biological pathways. Information about tissue expression of the proteins is used to filter the results
Input of the workflow
The input of the workflow is a drug-event pair.
For the clinical events, the following types are allowed:
1) UMLS CUI concept identifiers (single identifier or a list of identifiers
2) clinical events observed as adverse drug reactions according to the EU-ADR project
For the drug, a ATC code (7 digit level) is required
Output of the workflow
As result a list of connecting proteins as well as a list of pathways is provided.
The results can be visualized as a network using Cytoscape. The network is a multi-partite graph, in which the nodes are the event, the drug and the proteins, and the edges the associations between these nodes. In addition, all the evidences supporting the associations can be explored in the graph representation.
The results of the analyisis through biological pathways is summarized in an html file.2011-03-11 17:27:32.929 CET4b08aa99-b8dc-4318-9bf3-0cf0350ab3b22011-01-04 17:43:08.489 CET14abaab8-def4-4893-bd09-0243317c3a2f2011-02-10 10:36:57.584 CET2720a061-814b-4cf5-9d49-653a1c738e372010-07-29 09:51:48.234 CEST1b8280dd-fcd2-4f10-bdd9-3159f0cf3a9e2011-02-10 10:31:55.239 CETdcc4c0b1-0b8a-4c90-92af-ea02dc89e48f2011-04-18 17:30:43.73 CEST0c4617d8-938b-497a-bd9b-e24a888813332010-09-17 10:49:31.705 CEST2f0b90b4-41c1-4675-bbbb-37ee904f88b42011-01-14 18:10:30.484 CET4780f614-18eb-4264-ab87-5b53914f7f082011-07-29 15:43:04.301 CEST841e6b3c-7b1b-4e30-a333-d4876429e1f22011-01-13 15:08:13.15 CETed4d02f5-5289-42ac-aa18-6939e670363b2011-01-07 11:05:51.928 CETThe signal substantiation workflow seeks to establish a connection between the clinical event and the drug through different paths:
(i) through proteins in common among the proteins that are drug targets or metabolite targets and proteins associated to the clinical event
(ii) through proteins that are drug targets or metabolite targets and proteins associated to the clinical event that participate in a common biological pathway.
The workflow proceeds as follows:
First, it checks if there are proteins that are annotated both to the clinical event and to the drug (NESTED WORKFLOW ADR_substantiation_through_proteins).
Second, it looks for connections between the drug and the clinical event through biological pathways. Information about tissue expression of the proteins is used to filter the results.
Input of the workflow:
The input of the workflow is a drug-event pair.
For the clinical events, the following types are allowed:
1) UMLS concept identifiers (UMLS CUI)
2) clinical events observed as adverse drug reactions according to the EU-ADR project (see for details)
For the drug, a ATC code (5th level, seven digits) is required. NOTE: only one ATC code can be processed at a time
Output of the workflow
As result a list of connecting proteins as well as a list of pathways is provided.
The results can be visualized as a network using Cytoscape. The network is a multi-partite graph, in which the nodes are the event, the drug and the proteins, and the edges the associations between these nodes. In addition, all the evidences supporting the associations can be explored in the graph representation.
The results of the analysis through biological pathways is summarized in an html file.2011-07-29 15:31:15.587 CESTEU-ADR IMIM2010-07-19 13:20:24.541 CEST260f0cc1-0e85-44d3-83fc-9efa5c72fdea2011-03-11 18:06:26.209 CETbf84dfe6-5cbe-488b-86e4-4a71ece58e692010-09-08 15:35:53.307 CEST2fe89980-66f4-4bea-9c9e-c28ef4ea10ac2011-01-24 17:10:29.201 CET21f344c5-c9f9-4801-af16-599fec21492b2011-01-13 16:32:59.459 CETAnna Bauer-Mehren2010-07-19 13:20:18.173 CESTe6af487b-f382-43ce-89fd-1760fb3e11bd2011-03-11 18:10:19.899 CET4346eb60-27f6-4c39-8492-3b400affc3fa2011-02-08 17:23:41.806 CETAnna Bauer-Mehren
Integrative Biomedical Informatics Laboratory (GRIB, IMIM-Hospital del Mar, UPF), Barcelona, Spain.
This workflow is distributed under the GNU GPL licence (http://www.gnu.org/licenses/gpl.html).2011-07-29 15:55:07.542 CEST3d05b413-9350-46d1-afae-f1db198659c72010-09-17 10:40:56.793 CESTd5bc6c59-70e8-43fe-9212-191b0040b8882011-01-04 11:45:28.859 CETb395013e-3879-47e8-822a-18a8a2d431492011-01-04 17:41:43.118 CET510cab98-882c-4510-8959-fdbc3432fe9a2011-02-04 15:29:18.911 CET64f4a75e-d537-42bb-85fd-895bd35969c22011-01-13 15:54:42.790 CETeef744ef-73f2-46c4-a707-9dde6e6989ae2011-01-24 15:28:34.452 CETf4184e56-45ab-4ca0-96f7-4f697a7c2f702011-01-27 14:50:24.104 CETThe signal substantiation workflow seeks to establish a connection between the clinical event and the drug through different paths:
(i) through proteins in common among the proteins that are drug targets or metabolite targets and proteins associated to the clinical event
(ii) through proteins that are drug targets or metabolite targets and proteins associated to the clinical event that participate in a common biological pathway.
The workflow proceeds as follows:
First, it checks if there are proteins that are annotated both to the clinical event and to the drug (NESTED WORKFLOW ADR_substantiation_through_proteins)
Second, it tries to connect drug and event through biological pathways. Here, it checks if there are proteins from drug and event side which are expressed in the same tissue and also annotated to the same biological pathway.
As adverse event, the following event types are allowed:
1) events as defined in the EU-ADR project such as UGIB
2) UMLS CUI concept identifiers
As drug input 7 digit drug ATC codes are allowed.
As result a list of intersecting proteins as well as a list of pathways is provided.
If any of the two lists is not empty, the drug-event pair is substantiated as drug safety signal.
For the intersecting proteins, a Cytoscape graph is generated for user-friendly visualization. It contains the event, drug and their annotated proteins as well as additional information such as links to publications etc.
For the intersecting pathways a html page summarizing the results is generated.
2011-03-11 17:16:15.257 CETa41f5504-baa0-4b99-81ab-f0fef12349792011-03-16 12:43:42.391 CETAnna Bauer-Mehren
Integrative Biomedical Informatics Laboratory (GRIB, IMIM/UPF), Barcelona, Spain2011-03-01 10:50:38.460 CET4f30225c-d702-48ee-9c94-0b631e30f7ed2011-02-07 16:16:31.810 CETThe signal substantiation workflow seeks to establish a connection between the clinical event and the drug through different paths:
(i) through proteins in common among the proteins that are drug targets or metabolite targets and proteins associated to the clinical event
(ii) through proteins that are drug targets or metabolite targets and proteins associated to the clinical event that participate in a common biological pathway.
The workflow proceeds as follows:
First, it checks if there are proteins that are annotated both to the clinical event and to the drug (NESTED WORKFLOW ADR_substantiation_through_proteins)
Second, it looks for connections between the drug and the clinical event through biological pathways. Information about tissue expression of the proteins is used to filter the results
Input of the workflow
The input of the workflow is a drug-event pair.
For the clinical events, the following types are allowed:
1) UMLS CUI concept identifiers (single identifier or a list of identifiers)
2) clinical events observed as adverse drug reactions according to the EU-ADR project (see "Bauer-Mehren A, van Mullingen E, Carrascosa MC, Lopes P, Oliveira JL, Avillach P,
Gayo Diallo, Mestres J, Boyer S, Sanz F, Kors J, Furlong LI.
Workflows for the automatic filtering and substantiation of drug safety signals, 2011" for details)
For the drug, a ATC code (5th level, seven digits) is required.
Output of the workflow
As result a list of connecting proteins as well as a list of pathways is provided.
The results can be visualized as a network using Cytoscape. The network is a multi-partite graph, in which the nodes are the event, the drug and the proteins, and the edges the associations between these nodes. In addition, all the evidences supporting the associations can be explored in the graph representation.
The results of the analyisis through biological pathways is summarized in an html file.2011-03-11 17:48:07.519 CETbe6fdb73-7d48-4f77-9928-0fa22b8bd9542011-07-29 15:48:53.988 CEST9ff8bd28-c30e-4a3a-a0c0-244875db38d12011-07-29 15:34:41.634 CESTae84b161-c6b7-4b21-9f75-2497845699a92011-02-10 11:14:48.730 CET97d747e1-bd62-4a94-bef0-f31729f898fc2011-03-01 10:51:28.485 CET58bbae56-adfb-44c2-9b50-0a055c6559702011-01-17 10:38:00.451 CET29f2b085-a292-4a86-8d90-2e9a965664282011-02-10 11:26:28.282 CETd42fa9b2-722c-4842-b57a-d66e98a651562011-01-17 12:36:51.706 CET96b888b5-0878-4702-84d0-447e7907feec2011-01-04 16:34:24.129 CETf9b47244-65d6-4589-8718-b5e33ef485bd2011-01-13 16:38:20.39 CET0095e0ec-82cd-49ab-9e01-60bdd38172242011-01-24 15:32:15.832 CETAnna Bauer-Mehren
Integrative Biomedical Informatics Laboratory (GRIB, IMIM-Hospital del Mar, UPF), Barcelona, Spain.
This workflow distributed under the GNU GPL licence (http://www.gnu.org/licenses/gpl.html).2011-07-29 15:48:53.589 CESTe2c37fc0-0f67-4d25-8cbb-b37672fc6f192011-01-21 14:21:30.282 CET7a29253f-18a9-4d66-bc12-b0ba271583092011-01-10 12:49:12.709 CET4513d220-c9b3-4c07-8448-554009484ead2011-02-10 11:37:58.38 CET77ddd0cf-245b-4f5e-b041-57f40add07232011-02-10 11:34:34.773 CET42b2ed0c-0986-4653-b953-a0514a4849d02011-01-24 15:29:05.764 CET69676201-0660-4b18-9e0f-5f103d4675232011-01-13 16:31:34.241 CET8e17ab19-7c07-4906-a32f-a416f706188d2010-09-08 15:34:46.474 CEST2af370dd-e15f-452d-849d-201f719696722011-02-08 17:31:49.61 CETc4abbd34-6df9-47ea-acdc-18161d73f58c2011-03-10 11:38:51.140 CETa76a5bbb-91e9-4b5b-b371-83adbb3c2f002011-01-13 15:56:40.508 CET4a634e4a-1597-4a81-8791-c5fd2f6259bb2011-07-29 15:41:07.553 CEST7ff8652c-45ab-446f-b865-79c80d90880a2011-01-17 14:06:06.709 CET0ee7519a-82a4-4f8f-ac1e-6b4a0af1ca8c2011-04-15 09:56:30.896 CESTbbb9fd64-fe0e-4bb4-9604-ec046550ce022011-07-29 15:35:57.399 CEST220f1971-ff47-41eb-84a2-129aca61874b2011-01-27 14:13:58.356 CETEUADR IBI-CGL signal substantiation through pathways2011-02-08 18:02:07.470 CET86bbb993-bfd1-455c-ad86-34cd0bf012af2011-02-08 17:29:56.605 CET37da3e95-eeed-450f-bf0a-9037a652e5002011-01-24 17:29:39.214 CET8cefd2ea-bd66-440a-851d-f6cf69e2ec822011-03-11 18:08:46.493 CET055460a6-d3fe-4572-8acc-b0cb52a80e5b2011-01-27 14:31:51.598 CETd46cd2df-d9a7-4508-9364-bc45cbe8158e2011-01-13 16:20:17.110 CETa75d9a51-eff5-406c-87e4-9b819a305c0b2011-01-04 11:19:54.815 CET314d80ed-264b-4396-a047-2f628bea91612010-09-17 10:43:21.150 CEST1f1150d1-7d13-40de-bb63-b522fe0cc5272011-03-16 12:31:21.793 CET2a0e987e-189e-485c-9a44-b13fb379d4592010-12-21 15:44:16.508 CET8c38e822-a0f2-410e-85ee-91323183e0e02011-01-24 17:15:33.722 CETf59f4c3a-a7d6-4df8-bf54-20cd54c95bad2011-01-04 13:53:35.962 CETb56066b4-fe8d-456a-a6b5-8487fb0f239c2011-02-08 18:02:49.55 CET26f73c21-400f-4c63-8b61-ca6d410a49ca2011-01-04 15:44:49.895 CETc95961bd-86db-47c8-9496-19da4b9c556e2011-03-11 18:04:51.917 CETbac7b5d0-0dce-4c32-9939-6c46467be64d2011-02-11 17:57:28.182 CETbce8d803-d64b-434f-af97-31aebc72300a2011-01-14 18:06:06.550 CET7dcbaabc-a79e-4438-8203-cfd54c97445f2011-01-21 14:43:56.580 CETThe signal substantiation workflow seeks to establish a connection between the clinical event and the drug through different paths:
(i) through proteins in common among the proteins that are drug targets or metabolite targets and proteins associated to the clinical event
(ii) through proteins that are drug targets or metabolite targets and proteins associated to the clinical event that participate in a common biological pathway.
The workflow proceeds as follows:
First, it checks if there are proteins that are annotated both to the clinical event and to the drug (NESTED WORKFLOW ADR_substantiation_through_proteins)
Second, it looks for connections between the drug and the clinical event through biological pathways. Information about tissue expression of the proteins is used to filter the results
Input of the workflow
The input of the workflow is a drug-event pair.
For the clinical events, the following types are allowed:
1) UMLS CUI concept identifiers (single identifier or a list of identifiers
2) clinical events observed as adverse drug reactions according to the EU-ADR project
For the drug, a ATC code (5th level, seven digits) is required.
Output of the workflow
As result a list of connecting proteins as well as a list of pathways is provided.
The results can be visualized as a network using Cytoscape. The network is a multi-partite graph, in which the nodes are the event, the drug and the proteins, and the edges the associations between these nodes. In addition, all the evidences supporting the associations can be explored in the graph representation.
The results of the analyisis through biological pathways is summarized in an html file.2011-03-11 17:29:48.732 CETfc036ee8-4923-46c9-ab97-48fd1d0edba42011-01-04 17:35:51.643 CETd9173713-01e6-42cc-a1e3-cbf3ef27a6b32011-01-13 14:48:14.496 CET5b69bd99-3672-45f0-9518-c0186ea883452011-01-25 09:30:05.429 CETf487558d-5599-490a-9c57-8eeb3f9537ac2010-09-30 18:11:10.559 CEST4183fd75-868c-4209-9b1f-1a69834022882010-09-17 10:44:54.881 CEST658773b8-c856-4e48-a0b8-50e41be3d69d2010-12-20 15:49:39.984 CET9aa3115d-bd94-4143-9527-a47bdbda1c3e2010-09-08 17:07:48.587 CEST88f4c8d8-44e3-46c7-8a2c-54f67b9379822011-01-27 14:45:00.403 CETee4f5456-69c2-41e9-af9d-94e919a4f01a2011-01-14 18:13:16.336 CETSignal substantiation through proteins and pathways2011-03-01 10:50:53.142 CETf13ae848-8516-4192-9e86-4aff2853694d2011-01-07 13:02:55.763 CETc37dbf69-e5ac-451a-b579-163c7ac5d6652011-01-17 10:32:32.30 CET88f6405e-9afb-4f26-9a78-36c60e5a4dcd2011-01-17 12:32:11.716 CETda9c07a9-50c8-4d2f-9fe2-01ac2b82666e2011-03-16 11:45:43.687 CETfca2019e-0450-45b8-8f43-9d05583f56982011-02-08 17:38:35.876 CET423144e5-b1a3-44e0-a4c7-2033e11180852011-01-07 13:14:01.754 CET5625eddc-85bc-4748-a9d4-fea753e8860f2011-01-04 12:06:44.735 CET21e4c0a6-9a6c-4460-9c47-127288c8b2192011-01-07 17:01:53.65 CET23016ee1-4112-467f-8d95-7a0fccec501d2011-01-13 15:52:05.450 CET1b852c51-9908-46b1-b68c-3f169682f23e2011-01-17 12:09:55.130 CETa4c22227-00af-4525-bd90-2741da71a8462010-09-30 17:59:44.739 CESTThe signal substantiation workflow seeks to establish a connection between the clinical event and the drug through different paths:
(i) through proteins in common among the proteins that are drug targets or metabolite targets and proteins associated to the clinical event
(ii) through proteins that are drug targets or metabolite targets and proteins associated to the clinical event that participate in a common biological pathway.
The workflow proceeds as follows:
First, it checks if there are proteins that are annotated both to the clinical event and to the drug (NESTED WORKFLOW ADR_substantiation_through_proteins).
Second, it looks for connections between the drug and the clinical event through biological pathways. Information about tissue expression of the proteins is used to filter the results.
Input of the workflow:
The input of the workflow is a drug-event pair.
For the clinical events, the following types are allowed:
1) UMLS concept identifiers (UMLS CUI), a single identifier of a list of identifiers are accepted.
2) clinical events observed as adverse drug reactions according to the EU-ADR project (see http://ibi.imim.es/ADR_Substantiation.html for details)
For the drug, a ATC code (5th level, seven digits) is required. NOTE: only one ATC code can be processed at a time.
Output of the workflow:
1) List of Drug-Event-Liniking proteins:
The results can be visualized as a network using Cytoscape. The network is a multi-partite graph, in which the nodes are the event, the drug and the proteins, and the edges the associations between these nodes. In addition, all the evidences supporting the associations can be explored in the graph representation.
2)List of pathways:
The results of the analysis through biological pathways is summarized in an html file.2011-07-29 15:38:07.333 CEST8605e865-958b-4f8e-834e-2806d9b1582e2011-01-07 11:06:46.487 CETea3c8053-5bbe-4e33-bd69-2959d54efd112011-01-13 16:18:36.312 CET22bbbb79-c782-4b30-8f56-94997ae64f872011-02-08 17:59:04.315 CETa12cecc7-2962-4b13-89d5-3b60eaf696482011-01-04 12:56:07.950 CETb7af5884-8ad6-4201-a2b5-6d7a2d6160ad2010-09-08 15:45:03.444 CESTThe signal substantiation workflow seeks to establish a connection between the clinical event and the drug through different paths:
(i) through proteins in common among the proteins that are drug targets or metabolite targets and proteins associated to the clinical event
(ii) through proteins that are drug targets or metabolite targets and proteins associated to the clinical event that participate in a common biological pathway.
The workflow proceeds as follows:
First, it checks if there are proteins that are annotated both to the clinical event and to the drug (NESTED WORKFLOW ADR_substantiation_through_proteins)
Second, it lootries to connect drug and event through biological pathways. Here, it checks if there are proteins from drug and event side which are expressed in the same tissue and also annotated to the same biological pathway.
As adverse event, the following event types are allowed:
1) events as defined in the EU-ADR project such as UGIB
2) UMLS CUI concept identifiers
As drug input 7 digit drug ATC codes are allowed.
As result a list of intersecting proteins as well as a list of pathways is provided.
If any of the two lists is not empty, the drug-event pair is substantiated as drug safety signal.
For the intersecting proteins, a Cytoscape graph is generated for user-friendly visualization. It contains the event, drug and their annotated proteins as well as additional information such as links to publications etc.
For the intersecting pathways a html page summarizing the results is generated.
2011-03-11 17:17:27.733 CET501fec94-9965-4157-b32e-867a106712f32011-01-14 18:22:44.494 CET5c12e2cd-c510-4478-bda2-31d5092e0a0a2011-03-03 17:31:49.398 CETd08bc93b-51c4-4c40-bd72-11d549c32ead2011-01-13 14:06:02.321 CETe64aa3ae-eea5-4175-9d7f-21c3e04c99522011-01-27 14:16:52.272 CET1a2f5201-4619-486d-9954-2be1741631b12011-03-11 18:03:10.628 CETae013666-d74a-4624-ab6d-2d39db1ec8b02011-01-27 14:02:11.88 CET151afddc-dd5c-4ed2-beb8-131785f2b8bb2011-04-18 17:32:11.514 CEST44ef6149-c0e2-4466-90b2-f13051fbe7ca2011-01-13 15:49:08.268 CET1bcb72f3-d887-46db-8987-5110137dee7c2011-01-13 16:56:08.617 CETbaedf8f8-43c9-41f8-b5f8-2be50598b57a2011-07-29 16:38:30.656 CESTe5ff72f4-929a-47fb-8592-cae2dbbbd2e02011-01-14 18:29:12.87 CET53931c4d-2c75-4148-acde-8f69bb7fd6262011-01-14 18:03:03.413 CETc73e86bd-e273-493b-9d5c-b8745dff38a02011-07-29 15:58:41.698 CESTa902b378-4626-4df8-809a-93123c33c9a92011-01-04 12:15:24.2 CETcc468b4a-24fe-4463-ad13-fec4ff0264412011-01-04 11:14:23.26 CET24cb7be8-e08f-4491-8bf8-35b00b1184952010-08-26 16:41:14.887 CEST0ae5c9ec-423a-42eb-ba9a-be3c9e02f3232011-01-27 12:55:00.403 CET39610a7c-e061-4f9d-bd80-88309bbd6ab92011-01-17 11:32:10.27 CET5e2ff5a7-5420-4e9f-b02e-114a8e2dc8632011-02-08 14:40:24.758 CET78c2ffad-6362-4ab3-b4b7-934b210ef48b2010-12-20 15:33:23.98 CETe33179de-2871-42c8-8cb1-f04b8e6491812011-01-27 12:47:09.176 CET4d1f9484-623d-40a4-bd35-a7ae467597062011-02-08 18:01:45.640 CET87ce4583-2a1f-477c-9c17-9253f6bf35b92010-09-14 15:33:56.170 CEST9c0b50d0-9972-4be4-9fdd-81eeb5643dff2011-01-27 14:25:54.843 CETf2f5f285-9c68-4a07-a77e-ffc3995a87382011-01-04 13:44:31.852 CETbfb6d7b3-3dd3-43f4-866d-10d2d658bd9a2010-12-22 11:59:44.908 CET55639062-218e-41bb-839e-d2c3d4659a1c2010-08-26 17:15:56.889 CESTAnna Bauer-Mehren
Integrative Biomedical Informatics Laboratory (GRIB, IMIM-Hospital del Mar, UPF), Barcelona, Spain2011-03-11 17:17:25.944 CETb0ee9766-858e-46f7-a2cb-d38178b66a242011-01-13 14:29:33.126 CET9c33a4c4-433f-491f-8dc5-573094ea6e712011-03-11 17:29:53.532 CET6dfd8b4c-94c4-4c81-b9a2-426ef3cf6a4a2011-02-08 17:22:24.892 CET58589cdb-d8d6-45a3-83c5-116afa1f09d32011-01-17 14:03:03.793 CET4a5833ed-2c3c-4fbb-9f4e-0cf112d4eb4e2011-03-11 17:27:44.735 CETde788bee-1e95-4c28-a5b6-0730d2feea472011-07-29 17:34:54.170 CESTfc614a9b-6d64-47a1-8ec9-1e0906f169a22011-03-16 15:43:22.514 CET1dfeeb2f-41ee-445d-b780-38367b4bcc782010-09-30 17:58:44.713 CESTb8238866-091e-4bfd-8b53-3169af5e67ae2011-01-04 12:09:27.450 CETb54625a7-01c7-451c-9c07-2e97ae8ba3262011-01-04 12:57:37.762 CETThe signal substantiation workflow seeks to establish a connection between the clinical event and the drug through different paths:
(i) through proteins in common between the drug-target and the event-protein profiles.
(ii) assessing if the proteins in the drug-target profile and in the event-protein profile participate in a common biological pathway.
The workflow proceeds as follows:
First, it checks if there are proteins that are annotated both to the clinical event and to the drug (NESTED WORKFLOW ADR_substantiation_through_proteins).
Second, it looks for connections between the drug and the clinical event through biological pathways. Information about tissue expression of the proteins is used to filter the results.
Input of the workflow:
The input of the workflow is a drug-event pair.
For the clinical events, the following types are allowed:
1) UMLS concept identifiers (UMLS CUI), a single identifier of a list of identifiers are accepted.
2) clinical events observed as adverse drug reactions according to the EU-ADR project (see http://ibi.imim.es/ADR_Substantiation.html for details)
For the drug, an ATC code (5th level, seven digits) is required. NOTE: only one ATC code can be processed at a time.
Output of the workflow:
1) List of Drug-Event-Liniking proteins:
The list of proteins that link the drug with the event.
The results can be visualized as a network using Cytoscape. The network is a multi-partite graph, in which the nodes are the event, the drug and the proteins, and the edges the associations between these nodes. In addition, all the evidences supporting the associations can be explored in the graph representation.
2)List of pathways:
The list of pathways from Reactome that connect the drug and the event.
The results of the analysis through biological pathways is summarized in an html file.2011-07-29 15:43:00.221 CEST30a8edbd-e0e9-45b9-9bd5-d879e8ff21d82011-01-27 12:58:43.572 CET39cc5e6e-78d7-4866-9e66-3ca38fbd08ec2011-03-11 17:48:10.78 CETfce0bbbe-4c42-427c-96f2-5240cbb65fca2011-02-11 17:30:43.102 CETThe signal substantiation workflow seeks to establish a connection between the clinical event and the drug through different paths:
(i) through proteins in common between the drug-target and the event-protein profiles.
(ii) assessing if the proteins in the drug-target profile and in the event-protein profile participate in a common biological pathway.
The workflow proceeds as follows:
First, it checks if there are proteins that are annotated both to the clinical event and to the drug (NESTED WORKFLOW ADR_substantiation_through_proteins).
Second, it looks for connections between the drug and the clinical event through biological pathways. Information about tissue expression of the proteins is used to filter the results.
Input of the workflow:
The input of the workflow is a drug-event pair.
For the clinical events, the following types are allowed:
1) UMLS concept identifiers (UMLS CUI), a single identifier of a list of identifiers are accepted.
2) clinical events observed as adverse drug reactions according to the EU-ADR project (see http://ibi.imim.es/ADR_Substantiation.html for details)
For the drug, a ATC code (5th level, seven digits) is required. NOTE: only one ATC code can be processed at a time.
Output of the workflow:
1) List of Drug-Event-Liniking proteins:
The results can be visualized as a network using Cytoscape. The network is a multi-partite graph, in which the nodes are the event, the drug and the proteins, and the edges the associations between these nodes. In addition, all the evidences supporting the associations can be explored in the graph representation.
2)List of pathways:
The results of the analysis through biological pathways is summarized in an html file.2011-07-29 15:41:05.349 CESTc5771cbe-778c-4d6b-9f51-542995f8a23f2011-02-09 11:13:11.570 CETcc8f4d14-0ace-4cc8-8fff-f96b782390462010-09-17 10:14:44.745 CESTcc3023d1-fed7-4870-8dd9-467cea4c01fe2010-09-08 15:29:14.947 CESTdf79c8c4-6777-48c5-9d59-00ccab13e43d2011-01-04 16:13:26.111 CETa599c245-6cfe-43dd-b7d2-19c14af0f74c2011-03-15 13:36:17.408 CET843affcb-828f-4624-852b-a2e99dda68ea2011-01-04 16:06:49.11 CETf25c3841-8afe-4c63-94be-d2d454ddbf482011-01-24 12:30:57.285 CET71fee83a-3325-45d9-bd0a-48587b3f48a82011-07-29 13:31:09.487 CEST3b5e0702-3362-4022-9f9b-453acf20494e2011-01-04 16:10:11.817 CETec1e578a-6980-4a25-8a64-471a590d70c42011-01-07 13:22:32.167 CETa567a534-ba76-4fe9-9b1d-b535b46b8c302011-03-16 16:28:54.945 CETfcf5481e-d174-4011-a147-2b71d0a9c3b02011-03-11 17:50:43.833 CETa8565d7f-1947-49e1-9370-015e1f93b6032011-01-07 12:32:28.763 CET2fff42ee-f6f2-418e-8497-fd251d8aaf7d2011-01-10 12:53:40.490 CET92f5d4a5-e715-47fd-9566-d594c2c4b1fa2011-07-29 15:55:52.426 CESTd927ef64-6cd0-45e8-ae2b-9ff77bc317652011-01-04 16:18:35.499 CET6027b3fe-852f-425c-ae29-e863b16614332010-09-08 15:33:59.145 CEST42096290-5966-4a5d-9919-1e278e1f93092011-03-11 17:59:15.996 CET5ff684db-0eed-4796-8dc5-517f213b56a22011-01-10 10:27:14.753 CETbcf15876-78a9-4384-b1e6-3f5cc33ef6052011-02-11 17:38:29.129 CET69c9bf8b-a73f-4202-9294-21928d3c4a2c2011-02-08 18:34:07.981 CETb87d929c-35cb-42b2-9b85-5da55b5717202011-01-17 11:43:19.215 CET37d45e5b-c0ef-4f73-9a69-9b1048f8cc672011-01-13 14:01:08.590 CETfaa5e928-50d1-40db-a001-0b01d669c7022011-03-16 12:47:19.911 CETce77e21e-8c77-4206-a066-6c5b86e2d0372011-03-11 17:28:58.743 CET4d806381-6574-44f8-8a6d-b9112fb7cd4a2011-03-11 17:16:21.275 CETd4af1b5a-8069-4f1b-8053-b93d773a4b792011-01-24 14:13:35.151 CET5022eb2d-6711-4b4b-97e0-8c62f9776c452011-01-07 13:03:46.867 CET639a0092-1856-4571-abac-489ec118f6ec2011-02-08 18:16:17.218 CETThis workflow checks if there are proteins that are annotated to a given adverse event and at the same time target of the given drug. (NESTED WORKFLOW EUADR_IBI_CGL_signal_substantiation_through_proteins)
Moreover, it tries to connect drug and event through biological pathways. It checks if there are proteins, which are expressed in the same tissue and also annotated to the same pathway.
As adverse event, the following event types are allowed:
1) events as defined in the EU-ADR project such as UGIB
2) UMLS CUI concept identifiers
As drug input 7 digit drug ATC codes are allowed.
As result a list of intersecting proteins as well as a list of intersecting pathways is provided.
If any of the two lists is not empty, the drug-event pair is substantiated as signal.
For the intersecting proteins, there is a Cytoscape graph is generated for user-friendly visualization. It contains the event, drug and their annotated proteins as well as additional information such as links to publications etc.
For the intersecting pathways a html page summarizing the results is generated.
2011-02-08 18:14:22.946 CETa7637da4-1853-47eb-b6b6-6b6187de49682010-09-08 15:37:34.78 CESTf331ed5c-0969-4bb7-8888-69b3eccf80f92011-01-10 14:35:40.987 CET0b2a507a-92f5-47ba-8507-22940d44dc712011-03-03 17:21:51.236 CETAnna Bauer-Mehren
Integrative Biomedical Informatics Laboratory (GRIB, IMIM-Hospital del Mar, UPF), Barcelona, Spain.
This workflow distributed under the GNU GPL licence.2011-07-29 15:47:12.138 CEST69d9e94d-4948-4cf2-93ae-a6bb2cd71a8a2010-09-08 15:30:15.132 CEST8eccba26-6a75-488f-a99e-e73d57d7b6012011-01-05 17:56:23.509 CET3a624094-ede6-414f-a630-772aec4839c12011-02-08 17:27:34.284 CETab8a5018-e8a5-4518-8568-af60ea5aa6112011-01-24 15:17:23.110 CETb6fd1029-7f31-49bc-9854-dda121d530f72011-03-11 17:54:35.277 CETd9244dcd-5e77-49c5-bd98-5778ffcbf7a12011-01-07 15:29:00.928 CETThis workflow substantiates drug safety signals composed of a drug and an adverse reaction.
In more detail, the workflow tries to find feasible paths connecting the drug and the event.
First, it checks if there are proteins that are annotated to a given adverse event and at the same time target of the given drug. (NESTED WORKFLOW ADR_substantiation_through_proteins)
Second, it tries to connect drug and event through biological pathways. Here, it checks if there are proteins from drug and event side which are expressed in the same tissue and also annotated to the same biological pathway.
As adverse event, the following event types are allowed:
1) events as defined in the EU-ADR project such as UGIB
2) UMLS CUI concept identifiers
As drug input 7 digit drug ATC codes are allowed.
As result a list of intersecting proteins as well as a list of pathways is provided.
If any of the two lists is not empty, the drug-event pair is substantiated as drug safety signal.
For the intersecting proteins, a Cytoscape graph is generated for user-friendly visualization. It contains the event, drug and their annotated proteins as well as additional information such as links to publications etc.
sFor the intersecting pathways a html page summarizing the results is generated.
2011-03-03 17:21:53.838 CET0cf92a75-21ab-47be-9f1c-d413fbacd5da2011-02-10 11:09:51.857 CETa44786bf-7821-4d57-b90b-5f54ea6fed272011-01-07 13:15:50.669 CET2fc970ff-568d-4991-b44b-cf3081b98a502011-01-14 18:12:06.86 CET2564f676-3ac1-404d-9f5c-c6da9750a0ee2011-01-27 12:49:05.723 CET9fe4accf-0799-41bc-b67c-83a641e8311f2011-01-10 12:46:26.160 CET52875587-1ece-41ba-b152-3142f162b7542011-02-08 18:33:40.593 CET2fda05ef-384b-45cb-9378-146f8d831b222011-02-09 11:13:47.210 CET84cd4fd8-b1e6-4a0d-92e4-7b5fceda028f2011-03-01 10:50:54.88 CET0aabc0d8-a7bb-4b9b-a8aa-6d238ce4d7db2010-08-26 19:24:05.143 CEST646c546a-2c84-4ec5-84ad-53e28b4535652011-07-29 13:22:46.915 CESTe98d765a-4eec-4f87-b05f-04c5591efc9a2011-01-07 11:01:18.944 CETa59a2bab-0fc2-42fc-a036-3c11c376ec332011-01-24 14:13:23.143 CETaf850d3a-cda3-469a-872f-97933edf86872011-03-11 17:53:11.310 CETc6d50660-c118-4896-8133-479b21f168b12010-09-30 18:06:34.340 CEST5014d953-b1a6-4be6-82ca-9896815106452011-01-14 18:31:49.315 CETe5acb382-1cf9-4792-ab8f-ba1ad87eef822011-01-04 14:04:01.351 CET39d7d995-6fdd-4a26-8418-fa1d5ea8c6492011-03-03 17:34:35.658 CET7e527514-eeff-4319-b83b-72c529dfff7f2011-03-16 16:24:32.259 CETb684b5a4-aba5-43ba-a98e-d3b7a6b08be92011-02-08 15:44:37.643 CET8953bc2a-c768-4876-838b-b90aa79254ac2010-09-08 16:31:59.996 CESTThe signal substantiation workflow seeks to establish a connection between the clinical event and the drug through different paths:
(i) through proteins in common between the drug-target and the event-protein profiles.
(ii) through proteins that are drug targets or metabolite targets and proteins associated to the clinical event that participate in a common biological pathway.
The workflow proceeds as follows:
First, it checks if there are proteins that are annotated both to the clinical event and to the drug (NESTED WORKFLOW ADR_substantiation_through_proteins).
Second, it looks for connections between the drug and the clinical event through biological pathways. Information about tissue expression of the proteins is used to filter the results.
Input of the workflow:
The input of the workflow is a drug-event pair.
For the clinical events, the following types are allowed:
1) UMLS concept identifiers (UMLS CUI), a single identifier of a list of identifiers are accepted.
2) clinical events observed as adverse drug reactions according to the EU-ADR project (see http://ibi.imim.es/ADR_Substantiation.html for details)
For the drug, a ATC code (5th level, seven digits) is required. NOTE: only one ATC code can be processed at a time.
Output of the workflow:
1) List of Drug-Event-Liniking proteins:
The results can be visualized as a network using Cytoscape. The network is a multi-partite graph, in which the nodes are the event, the drug and the proteins, and the edges the associations between these nodes. In addition, all the evidences supporting the associations can be explored in the graph representation.
2)List of pathways:
The results of the analysis through biological pathways is summarized in an html file.2011-07-29 15:39:10.491 CESTThe signal substantiation workflow seeks to establish a connection between the clinical event and the drug through different paths:
(i) through proteins in common among the proteins that are drug targets or metabolite targets and proteins associated to the clinical event
(ii) through proteins that are drug targets or metabolite targets and proteins associated to the clinical event that participate in a common biological pathway.
The workflow proceeds as follows:
First, it checks if there are proteins that are annotated both to the clinical event and to the drug (NESTED WORKFLOW ADR_substantiation_through_proteins)
Second, it looks for connections between the drug and the clinical event through biological pathways. Information about tissue expression of the proteins is used to filter the results
Input of the workflow
The input of the workflow is a drug-event pair.
For the clinical events, the following types are allowed:
1) UMLS CUI concept identifiers (single identifier or a list of identifiers)
2) clinical events observed as adverse drug reactions according to the EU-ADR project (see ref. for details)
For the drug, a ATC code (5th level, seven digits) is required. NOTE: only one ATC code can be processed at a time
Output of the workflow
As result a list of connecting proteins as well as a list of pathways is provided.
The results can be visualized as a network using Cytoscape. The network is a multi-partite graph, in which the nodes are the event, the drug and the proteins, and the edges the associations between these nodes. In addition, all the evidences supporting the associations can be explored in the graph representation.
The results of the analysis through biological pathways is summarized in an html file.2011-03-15 13:45:23.148 CETThe signal substantiation workflow seeks to establish a connection between the clinical event and the drug through different paths:
(i) through proteins in common among the proteins that are drug targets or metabolite targets and proteins associated to the clinical event
(ii) through proteins that are drug targets or metabolite targets and proteins associated to the clinical event that participate in a common biological pathway.
The workflow proceeds as follows:
First, it checks if there are proteins that are annotated both to the clinical event and to the drug (NESTED WORKFLOW ADR_substantiation_through_proteins)
Second, it looks for connections between the drug and the clinical event through biological pathways. Information about tissue expression of the proteins is used to filter the results
Input of the workflow
The input of the workflow is a drug-event pair.
For the clinical events, the following types are allowed:
1) UMLS CUI concept identifiers (single identifier or a list of identifiers
2) clinical events observed as adverse drug reactions according to the EU-ADR project
For the drug, a ATC code (7 digit level) is required.
Output of the workflow
As result a list of connecting proteins as well as a list of pathways is provided.
The results can be visualized as a network using Cytoscape. The network is a multi-partite graph, in which the nodes are the event, the drug and the proteins, and the edges the associations between these nodes. In addition, all the evidences supporting the associations can be explored in the graph representation.
The results of the analyisis through biological pathways is summarized in an html file.2011-03-11 17:28:52.916 CETdd6c4837-c654-4f83-912e-d46922e0e0a02010-09-08 17:08:39.265 CEST3edb1d6f-00b2-45d6-94f9-c5b99d15f2eb2010-09-17 10:53:44.129 CEST54841a39-a37a-4b17-9e8b-5bd87f48c0b72011-02-08 14:46:45.233 CETdd12e38a-a639-4553-8fd5-fb278a79b4442011-01-07 12:39:58.59 CETADR_substantiation_through_proteinsatc00Workflow ATC input 2010-07-19 13:19:29.11 CESTWorkflow ATC input
The 7 digit atc code of a drug 2011-02-08 18:23:38.437 CETM01AH012010-07-19 13:19:34.980 CESTevent00UGIB2010-09-30 17:56:42.141 CESTWorkflow event input 2010-09-30 17:56:35.723 CESTWorkflow event input
Allowed events are:
1) events of type EUADR_EVENT as defined in the EUADR project
2) events of type UMLS being a CUI concept identifier2011-02-08 18:23:17.18 CETcytoscape00/home/user/cytoscape-v2.7.0/2011-01-10 12:49:14.15 CETcytoscape-v2.7.02011-01-10 12:46:17.448 CETinsert here the path to your local cytoscape installation e.g. /home/user/cytoscape2011-01-10 12:45:49.862 CETinsert here the path to your local cytoscape installation e.g. /home/user/cytoscape-v2.7.0/2011-01-10 12:49:09.100 CETInsert here the path to your local cytoscape installation e.g. /home/user/cytoscape-v2.7.0/2011-02-08 18:34:44.588 CETinsert here the path to your local cytoscape installation e.g. /home/user/cytoscape-v2.7.02011-01-10 12:46:10.80 CET/home/user/cytoscape-v2.7.02011-01-10 12:46:23.859 CETeventType00EUADR_EVENT2011-02-08 15:47:54.714 CETType of the event to be processed.
Must be either EUADR_EVENT if the event is defined in the EUADR project or UMLS if the event is a list of CUI concept identifiers2011-01-24 17:29:31.677 CETeventName00UGIB2011-02-08 16:00:45.505 CETName of the event. This is only required for user-friendly visualization of the results. In particular, if the input is a CUI concept identifier.2011-02-08 16:00:42.1 CETdiseaseProteinsOutputFull XML output for the get Disease Associated genes web service.2010-07-19 13:19:17.699 CESTFull XML output for the getDiseaseAssociatedProteins web service.2011-02-08 18:26:03.240 CETdrugTargetsOutputFull XML output for the get drug targets web service.2010-07-19 13:17:52.912 CESTFull XML output for the getDrugTargets web service.2011-02-08 18:26:57.248 CETconnectingProteinsList of proteins annotated to both, event and drug.2011-02-08 18:27:43.676 CETCytoscapeResultGraphCytoscape graph which can be openend in Cytoscape. Simply store this file using the file ending .xgmml and open it in Cytoscape. It contains the drug, event and their annotated proteins as well as supporting information such as link outs to publications etc.2011-02-08 18:25:06.342 CETdiseaseProteinsList of all proteins annoated to the event.2011-02-08 18:25:36.785 CETdrugTargetsList of proteins annotated to the drug.2011-02-08 18:26:26.286 CETgetSmileFromATCatc0smile00net.sf.taverna.t2.activitieswsdl-activity1.2net.sf.taverna.t2.activities.wsdl.WSDLActivityhttp://cgl.imim.es/axis2/services/cglAlertService?wsdlgetSmileFromATCnet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Parallelize1net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.ErrorBouncenet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Failovernet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Retry1.0100050000net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.InvokegetUniprotListFromSmilesmile0relationlist00net.sf.taverna.t2.activitieswsdl-activity1.2net.sf.taverna.t2.activities.wsdl.WSDLActivityhttp://cgl.imim.es/axis2/services/cglAlertService?wsdlgetUniprotListFromSmilenet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Parallelize1net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.ErrorBouncenet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Failovernet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Retry1.0100050000net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.InvokeXPath_getDrugTargetsxml-text0xpath0nodelistAsXML11net.sf.taverna.t2.activitieslocalworker-activity1.2net.sf.taverna.t2.activities.localworker.LocalworkerActivitynet.sourceforge.taverna.scuflworkers.xml.XPathTextWorkerdom4j:dom4j:1.6workflowdom4jdom4j1.6716010169java.lang.Stringtruexpath0'text/plain'java.lang.Stringtruexml-text0'text/xml'1nodelist1l('text/plain')1nodelistAsXML1l('text/plain')net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Parallelize1net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.ErrorBouncenet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Failovernet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Retry1.0100050000net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.InvokeXPath_getDiseaseProteinsxpath0xml-text0nodelistAsXML11net.sf.taverna.t2.activitieslocalworker-activity1.2net.sf.taverna.t2.activities.localworker.LocalworkerActivitynet.sourceforge.taverna.scuflworkers.xml.XPathTextWorkerdom4j:dom4j:1.6workflowdom4jdom4j1.6716010169java.lang.Stringtruexpath0'text/plain'java.lang.Stringtruexml-text0'text/xml'1nodelist1l('text/plain')1nodelistAsXML1l('text/plain')net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Parallelize1net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.ErrorBouncenet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Failovernet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Retry1.0100050000net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.InvokeIntersectionlist21list11intersection11net.sf.taverna.t2.activitieslocalworker-activity1.2net.sf.taverna.t2.activities.localworker.LocalworkerActivityorg.embl.ebi.escience.scuflworkers.java.StringSetIntersectionworkflowjava.lang.Stringtruelist11l('text/plain')java.lang.Stringtruelist21l('text/plain')1intersection1UserNameHere2011-03-15 16:02:54.411 CETUserNameHere2011-03-15 15:55:03.945 CETUserNameHere2011-03-15 16:17:09.846 CETUserNameHere2011-03-15 15:54:57.504 CETnet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Parallelize1net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.ErrorBouncenet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Failovernet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Retry1.0100050000net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.InvokeCheckConnectingProteinsintersectionList1fail0text0result00net.sf.taverna.t2.activitiesbeanshell-activity1.2net.sf.taverna.t2.activities.beanshell.BeanshellActivityworkflowjava.lang.StringtrueintersectionList1text/plainjava.lang.Stringtruetext0text/plainjava.lang.Stringtruefail0text/plain0result0net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Parallelize1net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.ErrorBouncenet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Failovernet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Retry1.0100050000net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.InvokeRemove_Duplicate_DTstringlist1strippedlist11net.sf.taverna.t2.activitieslocalworker-activity1.2net.sf.taverna.t2.activities.localworker.LocalworkerActivityorg.embl.ebi.escience.scuflworkers.java.StringStripDuplicatesworkflowjava.lang.Stringtruestringlist1l('text/plain')1strippedlist1UserNameHere2011-03-15 15:48:44.231 CETUserNameHere2011-03-15 16:16:34.632 CETUserNameHere2011-03-15 16:00:05.815 CETUserNameHere2011-03-15 15:49:17.216 CETUserNameHere2011-03-15 15:51:26.452 CETUserNameHere2011-03-15 15:50:45.603 CETnet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Parallelize1net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.ErrorBouncenet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Failovernet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Retry1.0100050000net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.InvokeRemove_Duplicates_DPstringlist1strippedlist11net.sf.taverna.t2.activitieslocalworker-activity1.2net.sf.taverna.t2.activities.localworker.LocalworkerActivityorg.embl.ebi.escience.scuflworkers.java.StringStripDuplicatesworkflowjava.lang.Stringtruestringlist1l('text/plain')1strippedlist1UserNameHere2011-03-15 15:51:13.700 CETUserNameHere2011-03-15 15:51:04.806 CETUserNameHere2011-03-15 15:47:36.710 CETUserNameHere2011-03-15 16:00:18.151 CETUserNameHere2011-03-15 16:15:50.837 CETnet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Parallelize1net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.ErrorBouncenet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Failovernet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Retry1.0100050000net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.InvokeConvertToCytoscapeGraphdrugTargetOutput0cytoscape0atc0event0proteinDiseaseOutput0fail0EUADR_resultGraph00net.sf.taverna.t2.activitieslocalworker-activity1.2net.sf.taverna.t2.activities.localworker.LocalworkerActivitynet.sourceforge.taverna.scuflworkers.xml.XSLTWorkerworkflowjava.lang.StringtrueproteinDiseaseOutput0text/plainjava.lang.StringtruedrugTargetOutput0text/plainjava.lang.Stringtruecytoscape0text/plainjava.lang.Stringtrueatc0text/plainjava.lang.Stringtrueevent0text/plainjava.lang.Stringtruefail0text/plain0EUADR_resultGraph0UserNameHere2011-03-15 17:19:27.826 CETUserNameHere2011-01-07 15:19:59.88 CETUserNameHere2011-02-09 18:20:18.750 CETUserNameHere2011-01-07 13:00:00.84 CETUserNameHere2011-02-09 18:18:35.500 CETUserNameHere2011-01-07 12:35:20.444 CETUserNameHere2011-01-04 17:35:25.767 CETUserNameHere2011-02-09 18:02:11.796 CETUserNameHere2011-01-10 14:35:06.569 CETUserNameHere2011-02-09 17:38:06.273 CETUserNameHere2011-01-07 12:32:23.168 CETUserNameHere2011-01-07 13:11:13.115 CETUserNameHere2011-01-07 13:15:44.385 CETUserNameHere2011-02-08 16:51:30.303 CETUserNameHere2011-01-10 10:27:03.462 CETUserNameHere2011-01-07 13:13:55.151 CETUserNameHere2011-03-15 17:20:56.270 CETUserNameHere2011-02-09 18:05:17.234 CETUserNameHere2011-02-09 17:48:12.734 CETUserNameHere2011-02-09 18:14:39.734 CETUserNameHere2011-02-10 10:22:36.353 CETUserNameHere2011-03-15 16:01:16.314 CETUserNameHere2011-01-04 17:42:55.522 CETUserNameHere2011-01-07 13:11:29.19 CETUserNameHere2011-01-07 10:59:55.696 CETUserNameHere2011-02-09 18:13:29.531 CETUserNameHere2011-01-10 12:48:57.256 CETUserNameHere2011-01-07 13:02:47.919 CETUserNameHere2011-02-09 18:08:07.46 CETUserNameHere2011-02-09 18:30:56.187 CETUserNameHere2011-02-10 10:24:41.228 CETUserNameHere2011-02-09 18:28:03.765 CETUserNameHere2011-02-09 17:51:53.921 CETUserNameHere2011-02-09 17:15:13.402 CETUserNameHere2011-02-09 11:10:10.350 CETUserNameHere2011-02-09 17:55:16.203 CETUserNameHere2011-01-24 14:12:31.876 CETUserNameHere2011-02-09 18:35:54.265 CETUserNameHere2011-02-10 10:28:36.81 CETUserNameHere2011-02-10 10:20:47.133 CETUserNameHere2011-01-07 11:06:39.488 CETUserNameHere2011-01-07 17:03:53.968 CETUserNameHere2011-01-04 17:28:55.745 CETUserNameHere2011-02-09 17:57:41.578 CETUserNameHere2011-01-10 12:42:11.271 CETUserNameHere2011-02-10 10:26:06.861 CETUserNameHere2011-01-07 15:23:03.842 CETUserNameHere2011-02-09 18:32:22.562 CETUserNameHere2011-03-15 15:52:35.766 CETUserNameHere2011-01-07 10:59:16.782 CETUserNameHere2011-01-21 14:43:38.627 CETUserNameHere2011-02-09 17:53:13.531 CETUserNameHere2011-01-24 14:12:54.675 CETUserNameHere2011-01-07 12:59:20.325 CETUserNameHere2011-02-09 17:47:56.968 CETUserNameHere2011-02-09 17:59:21.937 CETUserNameHere2011-01-04 17:41:26.968 CETUserNameHere2011-02-09 17:34:19.484 CETUserNameHere2011-01-07 12:39:33.114 CETUserNameHere2011-02-09 18:04:20.718 CETUserNameHere2011-01-07 15:28:56.549 CETUserNameHere2011-02-09 17:50:34.312 CETUserNameHere2011-01-07 11:00:56.265 CETUserNameHere2011-01-07 11:05:44.551 CETUserNameHere2011-01-07 17:01:44.948 CETUserNameHere2011-01-07 11:04:06.140 CETUserNameHere2011-02-09 18:34:05.937 CETUserNameHere2011-02-09 17:56:21.375 CETUserNameHere2011-02-09 18:10:25.781 CETUserNameHere2011-01-07 13:08:28.15 CETUserNameHere2011-02-08 15:42:36.568 CETUserNameHere2011-02-09 18:09:37.359 CETnet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Parallelize1net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.ErrorBouncenet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Failovernet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Retry1.0100050002net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.InvokeXQuery_getStatusvalue00net.sf.taverna.t2.activitiesstringconstant-activity1.2net.sf.taverna.t2.activities.stringconstant.StringConstantActivity//ns1:creator/ns1:statusnet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Parallelize1net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.ErrorBouncenet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Failovernet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Retry1.0100050000net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.InvokeWarningStatusgetSmileFromATCStatus0getUniProtFromSmileStatus0getDiseaseProteinsStatus0fail00answer00net.sf.taverna.t2.activitieslocalworker-activity1.2net.sf.taverna.t2.activities.localworker.LocalworkerActivitynet.sourceforge.taverna.scuflworkers.ui.WarnWorkerworkflowjava.lang.StringtruegetSmileFromATCStatus0'text/plain'java.lang.StringtruegetUniProtFromSmileStatus0text/plainjava.lang.StringtruegetDiseaseProteinsStatus0text/plain0answer00fail0UserNameHere2011-03-15 16:20:50.578 CETUserNameHere2011-01-24 15:18:27.628 CETUserNameHere2011-01-13 14:20:02.633 CETUserNameHere2011-03-15 14:57:53.97 CETUserNameHere2011-01-13 14:11:15.873 CETUserNameHere2011-01-24 15:21:48.319 CETUserNameHere2011-01-24 15:25:37.445 CETUserNameHere2011-02-08 15:47:20.243 CETUserNameHere2011-03-15 15:35:57.530 CETUserNameHere2011-03-15 17:03:26.511 CETUserNameHere2011-02-08 16:57:01.480 CETUserNameHere2011-03-15 15:20:34.83 CETUserNameHere2011-02-08 17:01:11.345 CETUserNameHere2011-03-15 15:24:43.248 CETUserNameHere2011-01-13 14:27:28.632 CETUserNameHere2011-03-15 14:59:11.164 CETnet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Parallelize1net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.ErrorBouncenet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Failovernet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Retry1.0100050000net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.InvokeXQuery_getTargetsvalue00net.sf.taverna.t2.activitiesstringconstant-activity1.2net.sf.taverna.t2.activities.stringconstant.StringConstantActivity//ns1:targetId/codenet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Parallelize1net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.ErrorBouncenet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Failovernet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Retry1.0100050000net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.InvokegetDiseaseAssociatedProteinsevent0associatedProteins00net.sf.taverna.t2.activitieswsdl-activity1.2net.sf.taverna.t2.activities.wsdl.WSDLActivityhttp://ibi.imim.es/axis2/services/AdrPathService?wsdlgetDiseaseAssociatedProteinsnet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Parallelize1net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.ErrorBouncenet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Failovernet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Retry1.0100050000net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.InvokeXPath_checkStatus1xpath0xml-text0nodelistAsXML11net.sf.taverna.t2.activitieslocalworker-activity1.2net.sf.taverna.t2.activities.localworker.LocalworkerActivitynet.sourceforge.taverna.scuflworkers.xml.XPathTextWorkerdom4j:dom4j:1.6workflowdom4jdom4j1.6716010169java.lang.Stringtruexpath0'text/plain'java.lang.Stringtruexml-text0'text/xml'1nodelist1l('text/plain')1nodelistAsXML1l('text/plain')net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Parallelize1net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.ErrorBouncenet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Failovernet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Retry1.0100050000net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.InvokeXPath_checkStatus2xpath0xml-text0nodelistAsXML11net.sf.taverna.t2.activitieslocalworker-activity1.2net.sf.taverna.t2.activities.localworker.LocalworkerActivitynet.sourceforge.taverna.scuflworkers.xml.XPathTextWorkerdom4j:dom4j:1.6workflowdom4jdom4j1.6716010169java.lang.Stringtruexpath0'text/plain'java.lang.Stringtruexml-text0'text/xml'1nodelist1l('text/plain')1nodelistAsXML1l('text/plain')net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Parallelize1net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.ErrorBouncenet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Failovernet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Retry1.0100050000net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.InvokeXPath_checkStatus3xpath0xml-text0nodelistAsXML11net.sf.taverna.t2.activitieslocalworker-activity1.2net.sf.taverna.t2.activities.localworker.LocalworkerActivitynet.sourceforge.taverna.scuflworkers.xml.XPathTextWorkerdom4j:dom4j:1.6workflowdom4jdom4j1.6716010169java.lang.Stringtruexpath0'text/plain'java.lang.Stringtruexml-text0'text/xml'1nodelist1l('text/plain')1nodelistAsXML1l('text/plain')net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Parallelize1net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.ErrorBouncenet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Failovernet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Retry1.0100050000net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.InvokegetSmileFromATC_atcsource0name0code0output00net.sf.taverna.t2.activitieswsdl-activity1.2net.sf.taverna.t2.activities.wsdl.xmlsplitter.XMLInputSplitterActivity<s:extensions xmlns:s="http://org.embl.ebi.escience/xscufl/0.1alpha"><s:complextype optional="false" unbounded="false" typename="databaseId" name="atc" qname="{http://service.alert.cgl.imim.es/xsd}databaseId"><s:elements><s:basetype optional="true" unbounded="false" typename="string" name="source" qname="databaseId>source" /><s:basetype optional="true" unbounded="false" typename="string" name="code" qname="databaseId>code" /><s:basetype optional="true" unbounded="false" typename="string" name="name" qname="databaseId>name" /></s:elements></s:complextype></s:extensions>falsesource0'text/plain'falsecode0'text/plain'falsename0'text/plain'0output0'text/xml'net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Parallelize1net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.ErrorBouncenet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Failovernet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Retry1.0100050000net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Invokesource_valuevalue00net.sf.taverna.t2.activitiesstringconstant-activity1.2net.sf.taverna.t2.activities.stringconstant.StringConstantActivityATCnet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Parallelize1net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.ErrorBouncenet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Failovernet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Retry1.0100050000net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Invokename_valuevalue00net.sf.taverna.t2.activitiesstringconstant-activity1.2net.sf.taverna.t2.activities.stringconstant.StringConstantActivitynet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Parallelize1net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.ErrorBouncenet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Failovernet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Retry1.0100050000net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.InvokegetDiseaseAssociatedProteins_eventsource0code0name0output00net.sf.taverna.t2.activitieswsdl-activity1.2net.sf.taverna.t2.activities.wsdl.xmlsplitter.XMLInputSplitterActivity<s:extensions xmlns:s="http://org.embl.ebi.escience/xscufl/0.1alpha"><s:complextype optional="false" unbounded="false" typename="databaseId" name="event" qname="{http://service.adrPath.ibi.imim.es/xsd}databaseId"><s:elements><s:basetype optional="true" unbounded="false" typename="string" name="source" qname="databaseId>source" /><s:basetype optional="true" unbounded="false" typename="string" name="code" qname="databaseId>code" /><s:basetype optional="true" unbounded="false" typename="string" name="name" qname="databaseId>name" /></s:elements></s:complextype></s:extensions>falsesource0'text/plain'falsecode0'text/plain'falsename0'text/plain'0output0'text/xml'net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Parallelize1net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.ErrorBouncenet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Failovernet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Retry1.0100050000net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.InvokeMerge_Liststringlist1concatenated00net.sf.taverna.t2.activitieslocalworker-activity1.2net.sf.taverna.t2.activities.localworker.LocalworkerActivityorg.embl.ebi.escience.scuflworkers.java.StringListMergeworkflowjava.lang.Stringtruestringlist1l('text/plain')0concatenated0UserNameHere2011-03-15 17:47:57.643 CETUserNameHere2011-03-16 11:15:42.370 CETUserNameHere2011-03-16 11:26:02.906 CETnet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Parallelize1net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.ErrorBouncenet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Failovernet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Retry1.0100050000net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.InvokeTellResultmessage0title0net.sf.taverna.t2.activitieslocalworker-activity1.2net.sf.taverna.t2.activities.localworker.LocalworkerActivitynet.sourceforge.taverna.scuflworkers.ui.TellWorkerworkflowjava.lang.Stringtruetitle0'text/plain'java.lang.Stringtruemessage0'text/plain'0answer0'text/plain'net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Parallelize1net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.ErrorBouncenet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Failovernet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Retry1.0100050000net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Invoketitle_valuevalue00net.sf.taverna.t2.activitiesstringconstant-activity1.2net.sf.taverna.t2.activities.stringconstant.StringConstantActivityDrug-event connection through proteinsnet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Parallelize1net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.ErrorBouncenet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Failovernet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Retry1.0100050000net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.InvokeMerge_DPstringlist1concatenated00net.sf.taverna.t2.activitieslocalworker-activity1.2net.sf.taverna.t2.activities.localworker.LocalworkerActivityorg.embl.ebi.escience.scuflworkers.java.StringListMergeworkflowjava.lang.Stringtruestringlist1l('text/plain')java.lang.Stringtrueseperator0'text/plain'0concatenated0UserNameHere2011-03-15 15:54:05.439 CETUserNameHere2011-03-15 16:02:13.906 CETUserNameHere2011-03-15 16:02:34.395 CETUserNameHere2011-02-10 10:47:33.906 CETnet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Parallelize1net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.ErrorBouncenet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Failovernet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Retry1.0100050000net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.InvokeMerge_DTstringlist1concatenated00net.sf.taverna.t2.activitieslocalworker-activity1.2net.sf.taverna.t2.activities.localworker.LocalworkerActivityorg.embl.ebi.escience.scuflworkers.java.StringListMergeworkflowjava.lang.Stringtruestringlist1l('text/plain')java.lang.Stringtrueseperator0'text/plain'0concatenated0UserNameHere2011-03-15 16:17:54.276 CETUserNameHere2011-02-10 10:47:33.906 CETUserNameHere2011-03-15 15:57:24.932 CETUserNameHere2011-03-15 16:03:16.76 CETnet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Parallelize1net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.ErrorBouncenet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Failovernet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Retry1.0100050000net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.InvokeFlatten_Listinputlist3output00net.sf.taverna.t2.activitieslocalworker-activity1.2net.sf.taverna.t2.activities.localworker.LocalworkerActivityorg.embl.ebi.escience.scuflworkers.java.FlattenListworkflow[Btrueinputlist3l(l(''))0output0UserNameHere2011-03-16 11:16:23.303 CETUserNameHere2011-03-16 11:25:06.390 CETUserNameHere2011-03-16 11:19:08.115 CETUserNameHere2011-03-16 11:11:10.76 CETUserNameHere2011-03-16 11:20:19.576 CETUserNameHere2011-03-16 11:30:35.918 CETnet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Parallelize1net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.ErrorBouncenet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Failovernet.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.Retry1.0100050000net.sf.taverna.t2.coreworkflowmodel-impl1.2net.sf.taverna.t2.workflowmodel.processor.dispatch.layers.InvokegetSmileFromATCatcgetUniprotListFromSmilesmileXPath_getDrugTargetsxml-textXPath_getDrugTargetsxpathXPath_getDiseaseProteinsxpathXPath_getDiseaseProteinsxml-textIntersectionlist2Intersectionlist1CheckConnectingProteinsintersectionListCheckConnectingProteinsfailCheckConnectingProteinstextRemove_Duplicate_DTstringlistRemove_Duplicates_DPstringlistConvertToCytoscapeGraphdrugTargetOutputConvertToCytoscapeGraphcytoscapeConvertToCytoscapeGraphatcConvertToCytoscapeGrapheventConvertToCytoscapeGraphproteinDiseaseOutputConvertToCytoscapeGraphfailWarningStatusgetSmileFromATCStatusWarningStatusgetUniProtFromSmileStatusWarningStatusgetDiseaseProteinsStatusgetDiseaseAssociatedProteinseventXPath_checkStatus1xpathXPath_checkStatus1xml-textXPath_checkStatus2xpathXPath_checkStatus2xml-textXPath_checkStatus3xpathXPath_checkStatus3xml-textgetSmileFromATC_atcsourcegetSmileFromATC_atcnamegetSmileFromATC_atccodegetDiseaseAssociatedProteins_eventsourcegetDiseaseAssociatedProteins_eventcodegetDiseaseAssociatedProteins_eventnameMerge_ListstringlistTellResultmessageTellResulttitleMerge_DPstringlistMerge_DTstringlistFlatten_ListinputlistdiseaseProteinsOutputdrugTargetsOutputconnectingProteinsCytoscapeResultGraphdiseaseProteinsdrugTargets6ebbf226-8fb0-4091-94d2-b1e8476604402011-02-09 17:48:16.625 CET5014d953-b1a6-4be6-82ca-9896815106452011-01-14 18:31:49.315 CET984a9292-80d5-4a03-bf77-cec858d566b32011-01-04 17:45:55.665 CETEUADR IBI-CGL signal substantiation through proteins2011-02-08 18:00:32.122 CETddc6814a-cbf4-4dda-a811-c62cac1253702011-02-09 17:38:26.900 CET1b852c51-9908-46b1-b68c-3f169682f23e2011-01-17 12:09:55.130 CET93d045f8-5566-400e-b931-2aca1f9b39472011-01-13 16:28:44.447 CET2f799556-78fe-4d91-a0b9-989191ba37032011-01-13 16:39:50.188 CET62ec5abb-7c12-4bb9-af57-456cbcbbda9e2011-01-10 12:42:16.19 CETf62bd8c1-d09f-44de-b891-2c79ae1174682011-03-15 17:15:21.271 CETde0177bc-8afe-45a1-8529-745eb94492ae2011-02-08 17:02:47.966 CETd471959c-29f3-49f6-bda2-5eaec8dd5ea82011-01-17 11:45:21.958 CETb54625a7-01c7-451c-9c07-2e97ae8ba3262011-01-04 12:57:37.762 CET3283fbbf-0535-4a4f-a865-8d4a46e029942011-02-09 17:38:10.996 CET651ca0ac-273a-4389-af28-84ce7367b4512011-03-15 17:42:28.239 CET6ec2cc26-423a-42f7-ac27-a9e7c87bdaf52011-02-09 17:23:41.748 CET7ff8652c-45ab-446f-b865-79c80d90880a2011-01-17 14:06:06.709 CETcad732c9-8359-465b-ba8c-b93fd44bfa542011-01-13 16:49:14.442 CETcc772697-d010-4057-b756-36c08166d6452011-01-17 10:35:59.185 CET6e2b4cbf-362f-458c-901a-9fd1be0c6a592011-03-16 11:16:28.606 CET62c3de99-9361-480c-ade0-4c3c3c7b54d12011-02-10 10:53:41.501 CET69676201-0660-4b18-9e0f-5f103d4675232011-01-13 16:31:34.241 CETc6d50660-c118-4896-8133-479b21f168b12010-09-30 18:06:34.340 CEST58589cdb-d8d6-45a3-83c5-116afa1f09d32011-01-17 14:03:03.793 CET53503b95-945b-46d3-8663-5b176536f52c2011-01-04 15:52:11.52 CETaf689045-45d3-4ca2-9e63-d833cdfd48032011-01-20 15:23:08.969 CET656f5a21-7dc4-4e46-a6e4-67fd197decfe2011-01-14 18:08:30.745 CET1bcb72f3-d887-46db-8987-5110137dee7c2011-01-13 16:56:08.617 CET0db3f322-5f1f-4505-bf6a-85c5a9eeb2892011-01-04 12:48:54.533 CET44ef6149-c0e2-4466-90b2-f13051fbe7ca2011-01-13 15:49:08.268 CET843affcb-828f-4624-852b-a2e99dda68ea2011-01-04 16:06:49.11 CET240b6e21-4a2b-4864-9fe4-24617da3c9232011-02-09 18:09:40.562 CET09b3d4f2-ac6b-49de-bc63-c4fc833798342010-09-08 15:39:11.360 CEST4e6551ac-5a84-4458-9c20-554bcf8f6af92011-02-09 18:10:29.46 CETa902b378-4626-4df8-809a-93123c33c9a92011-01-04 12:15:24.2 CETd19909e8-669b-4d65-9468-f760fd7fa7502011-01-07 17:04:00.846 CET7b7bf9ce-5249-4ad0-af27-ef7987d5c0512011-01-07 11:01:45.884 CETa44786bf-7821-4d57-b90b-5f54ea6fed272011-01-07 13:15:50.669 CET6ec9aa19-abe1-42de-a705-323f80a671312011-03-16 11:16:51.196 CETa59a2bab-0fc2-42fc-a036-3c11c376ec332011-01-24 14:13:23.143 CETADR_substantiation_through_proteins2011-03-03 17:26:30.535 CETa76a5bbb-91e9-4b5b-b371-83adbb3c2f002011-01-13 15:56:40.508 CET6953c726-0841-4a21-b77e-e7f6c2ca6dbc2011-02-10 10:21:11.613 CET653e4e25-055c-4379-9a83-2d1151d8478a2011-01-14 18:14:09.85 CETf487558d-5599-490a-9c57-8eeb3f9537ac2010-09-30 18:11:10.559 CEST9aa3115d-bd94-4143-9527-a47bdbda1c3e2010-09-08 17:07:48.587 CEST8038ad73-2341-401f-9a99-1c9f30862a902011-01-07 11:04:15.227 CETd5bc6c59-70e8-43fe-9212-191b0040b8882011-01-04 11:45:28.859 CETf331ed5c-0969-4bb7-8888-69b3eccf80f92011-01-10 14:35:40.987 CET23016ee1-4112-467f-8d95-7a0fccec501d2011-01-13 15:52:05.450 CETb80fba38-d085-4bef-924a-4178251076482011-01-04 15:49:32.364 CETf9b47244-65d6-4589-8718-b5e33ef485bd2011-01-13 16:38:20.39 CETcbb45c11-e394-4e86-8c64-ccd5ddac15572011-03-15 16:58:40.666 CET04372b6f-fcc3-4b2c-83ac-b64512f59ce22010-09-17 10:39:50.849 CEST20f2f5df-9b73-4c47-b553-b87ed68e70892011-02-10 10:47:58.865 CETb7af5884-8ad6-4201-a2b5-6d7a2d6160ad2010-09-08 15:45:03.444 CEST33ba9d75-43b9-40e6-a927-a2405aed31db2011-02-08 16:51:34.505 CETdd6c4837-c654-4f83-912e-d46922e0e0a02010-09-08 17:08:39.265 CESTa806ad18-4400-4a05-892d-60824552fb1d2011-03-16 11:26:10.901 CET5c5101bf-6e14-400c-bcd6-66a7b4f6094b2011-01-19 17:33:29.326 CETfc739216-5572-42da-b597-25164e559ad82011-03-16 11:30:48.20 CET252516db-cfe7-46d5-9881-9dec832ee3252011-02-08 15:59:28.584 CETf59f4c3a-a7d6-4df8-bf54-20cd54c95bad2011-01-04 13:53:35.962 CET8eccba26-6a75-488f-a99e-e73d57d7b6012011-01-05 17:56:23.509 CETbe65a81f-1248-489e-8568-c4a852d6824f2011-02-08 15:48:18.768 CETb66fe7cc-39dc-4949-afc0-83c195751d592011-01-04 17:36:27.395 CET5f5a4dee-045f-4720-b990-9445ce4ce6272010-09-30 18:03:28.544 CESTfc036ee8-4923-46c9-ab97-48fd1d0edba42011-01-04 17:35:51.643 CETAnna Bauer-Mehren
Integrative Biomedical Informatics Laboratory (GRIB, IMIM/UPF)2011-02-08 15:52:33.136 CETf2f5f285-9c68-4a07-a77e-ffc3995a87382011-01-04 13:44:31.852 CETabbe5ecd-c5c5-461f-9b16-860c7f8e6a172011-03-15 17:03:34.308 CETe57ad22d-32f9-4fc7-80d1-9186a849119b2011-01-07 15:27:40.662 CET37da3e95-eeed-450f-bf0a-9037a652e5002011-01-24 17:29:39.214 CETaf060e60-6938-4295-8797-8c749b8d40852011-01-14 18:04:03.419 CET76842ae5-75ab-40b2-a41a-c819c08de42a2011-02-09 17:59:28.250 CETAnna Bauer-Mehren2010-07-19 13:20:18.173 CEST2fff42ee-f6f2-418e-8497-fd251d8aaf7d2011-01-10 12:53:40.490 CETab8a5018-e8a5-4518-8568-af60ea5aa6112011-01-24 15:17:23.110 CET77ccfaf3-08a2-49da-812d-c02cca424c892011-03-15 15:24:47.4 CETAnna Bauer-Mehren
Integrative Biomedical Informatics Laboratory (GRIB, IMIM/UPF), Barcelona, Spain2011-03-03 17:27:24.897 CET24cb7be8-e08f-4491-8bf8-35b00b1184952010-08-26 16:41:14.887 CESTce90a78b-213d-4780-b28e-45585adcfd4c2011-02-10 10:23:45.17 CETa4c22227-00af-4525-bd90-2741da71a8462010-09-30 17:59:44.739 CEST8d0c6e40-d3b7-4e40-9c18-b7ced289aaa32011-02-09 18:18:39.484 CET3f105056-fcab-4bc4-8cf8-9951729b24df2011-01-04 12:17:29.826 CETe5acb382-1cf9-4792-ab8f-ba1ad87eef822011-01-04 14:04:01.351 CET15493c2e-a54c-493e-8898-710705b8c5d72010-09-08 16:38:16.856 CEST43b3cf7d-34d8-49d6-9eae-19e8a5d41cc12011-03-15 16:18:53.106 CETd59db508-04af-4d13-b5c6-5523ff815d7a2011-03-15 17:37:45.624 CETc92f43ec-b8a5-4238-bbba-c7e950131b3f2011-02-09 18:28:07.843 CET7aa10c7d-6fe1-4b77-8808-7cffa61ae3db2010-09-14 15:35:08.242 CESTed4d02f5-5289-42ac-aa18-6939e670363b2011-01-07 11:05:51.928 CETcb84c608-6105-4b6b-9bb7-77acb56389ed2010-09-17 10:52:24.545 CESTae92fb5d-fd57-4faa-ba70-55607ed783472011-01-17 12:38:05.300 CET501fec94-9965-4157-b32e-867a106712f32011-01-14 18:22:44.494 CETcc3023d1-fed7-4870-8dd9-467cea4c01fe2010-09-08 15:29:14.947 CEST2720a061-814b-4cf5-9d49-653a1c738e372010-07-29 09:51:48.234 CESTd46cd2df-d9a7-4508-9364-bc45cbe8158e2011-01-13 16:20:17.110 CET06b488ab-b4b6-4fdf-bf4e-557d1d5b0d2c2011-01-04 16:21:31.258 CET2f0b90b4-41c1-4675-bbbb-37ee904f88b42011-01-14 18:10:30.484 CET2a0e987e-189e-485c-9a44-b13fb379d4592010-12-21 15:44:16.508 CETAnna2010-07-19 13:20:04.607 CESTThis workflow substantiates drug safety signals which are composed of a drug and an adverse reaction.
In more detail, it checks if there are proteins that are annotated to a given adverse event and at the same time target of the given drug.
As adverse event, the following event types are allowed:
1) events as defined in the EU-ADR project such as UGIB
2) UMLS CUI concept identifiers
As drug input 7 digit drug ATC codes are allowed.
As result a list of intersecting proteins is provided. If this list is not empty, the drug-event pair is substantiated as signal.
Moreover, a Cytoscape graph is generated for user-friendly visualization. It contains the event, drug and their annotated proteins as well as additional information such as links to publications etc.
2011-03-03 17:27:12.912 CET8605e865-958b-4f8e-834e-2806d9b1582e2011-01-07 11:06:46.487 CET3b5e0702-3362-4022-9f9b-453acf20494e2011-01-04 16:10:11.817 CET5b69bd99-3672-45f0-9518-c0186ea883452011-01-25 09:30:05.429 CETb395013e-3879-47e8-822a-18a8a2d431492011-01-04 17:41:43.118 CET39610a7c-e061-4f9d-bd80-88309bbd6ab92011-01-17 11:32:10.27 CET9fe4accf-0799-41bc-b67c-83a641e8311f2011-01-10 12:46:26.160 CET076569ba-ad9a-4ba8-8f8e-66c56972887c2011-03-15 17:00:19.815 CET0ea7d095-fc78-475b-9a96-efc6e41811dc2011-01-04 15:43:14.845 CET40464dda-dfeb-4f4d-ad59-8d6800af40bd2011-02-08 17:01:17.380 CET2f700972-4f65-4993-9d83-d66122a575482011-01-13 16:13:22.795 CET935964c1-91b9-4e5f-9c32-ed5fccf9f9a22010-09-17 10:14:21.353 CEST7a9a9b49-6e78-4ad0-b3e6-d63926f362b32011-03-15 13:33:04.772 CET30c736d4-4c56-46cc-8612-f4c24e3e8bf42011-02-09 18:13:35.828 CET37d45e5b-c0ef-4f73-9a69-9b1048f8cc672011-01-13 14:01:08.590 CETf2c45435-2f63-4179-879b-323954bcd7732011-01-17 12:51:01.494 CET1897606e-1d7d-4c96-ab38-6ef1b9cf38ac2010-09-30 18:05:13.306 CEST9f6fca78-6d4d-4e62-90d4-2211905b83f12011-01-21 14:20:14.134 CET6548e9cf-5bec-477f-96a0-6b1d8c5d082d2011-02-08 18:26:56.320 CETbfb6d7b3-3dd3-43f4-866d-10d2d658bd9a2010-12-22 11:59:44.908 CETcc468b4a-24fe-4463-ad13-fec4ff0264412011-01-04 11:14:23.26 CETde97e1d3-167f-4dae-917d-197e2e4b27b32010-09-30 18:00:40.4 CEST554c0775-68cf-419c-8202-2f1baa1a9dca2011-01-04 12:04:35.852 CETa9eb117a-c4ac-4dbf-b89b-ad9f7d8411f42011-02-08 15:54:29.681 CETa063837a-bf23-42da-8892-eb8044555c192010-09-30 18:08:32.887 CESTd0f1571c-f4db-4fb7-876d-d753774020162011-02-09 17:56:25.750 CETfba94945-80a5-49b0-a6e3-af17dd3ef7f02011-02-09 17:34:29.497 CETd7824096-eb0c-4fb9-87f5-0341596b52112010-09-17 10:48:39.9 CEST26f73c21-400f-4c63-8b61-ca6d410a49ca2011-01-04 15:44:49.895 CETd927ef64-6cd0-45e8-ae2b-9ff77bc317652011-01-04 16:18:35.499 CET21f344c5-c9f9-4801-af16-599fec21492b2011-01-13 16:32:59.459 CETf13ae848-8516-4192-9e86-4aff2853694d2011-01-07 13:02:55.763 CET29d4ed3a-8ab6-4d17-95e3-a0f61f4c6bed2011-04-18 17:30:34.694 CEST8953bc2a-c768-4876-838b-b90aa79254ac2010-09-08 16:31:59.996 CEST6e32b8bb-01e4-4abc-a589-2577b16b8f9c2011-01-13 16:30:25.16 CETe8d8164d-cf5a-43ae-8ca6-18becacf8d8b2011-01-07 12:41:50.692 CET64f4a75e-d537-42bb-85fd-895bd35969c22011-01-13 15:54:42.790 CETc2380230-dead-428e-b027-c0ca4ed2233f2011-03-16 12:30:33.623 CET69d9e94d-4948-4cf2-93ae-a6bb2cd71a8a2010-09-08 15:30:15.132 CEST0b1a7caa-589a-4fe2-a52c-3b0611d4abb52011-01-24 17:14:53.841 CETf25c3841-8afe-4c63-94be-d2d454ddbf482011-01-24 12:30:57.285 CET5625eddc-85bc-4748-a9d4-fea753e8860f2011-01-04 12:06:44.735 CET37c313f4-fc7f-44fb-b486-75344db8f9332011-01-13 15:50:00.475 CETd4af1b5a-8069-4f1b-8053-b93d773a4b792011-01-24 14:13:35.151 CETfee13559-e86b-4418-9599-f2a1d6446c752011-01-13 16:50:29.626 CET7fc58eec-fb7e-4719-951c-f8c7402bdbdd2011-02-09 18:20:22.593 CET2b00853f-d2b9-4986-8085-fc3de81a76932010-09-08 17:25:02.20 CEST53931c4d-2c75-4148-acde-8f69bb7fd6262011-01-14 18:03:03.413 CETff1f9074-7f1b-4f04-b09b-25e8d10759332011-01-17 11:08:52.797 CETf6450ab7-d5fe-4ae5-b7f0-36f7a29cb8b42011-01-04 12:52:56.78 CETcf360835-3b60-421b-a4a3-ff67fffa4aaf2011-01-17 11:24:32.777 CET0ed622c5-32b6-4791-be7a-382da065f0862010-12-20 16:03:47.872 CET776ad2f6-e9ba-4c99-ad3a-772b5e9cb61b2010-12-21 15:39:22.876 CETEU-ADR IBI-CGL signal substantiation through proteins2011-02-08 15:48:19.784 CETa7637da4-1853-47eb-b6b6-6b6187de49682010-09-08 15:37:34.78 CEST5ff684db-0eed-4796-8dc5-517f213b56a22011-01-10 10:27:14.753 CET78c2ffad-6362-4ab3-b4b7-934b210ef48b2010-12-20 15:33:23.98 CET68aa3ee9-2188-46fe-b328-58cb9ffcef612011-03-16 11:12:34.645 CETbdcb966c-e208-4f2b-9e51-507e2da5a3782011-03-03 17:27:27.737 CET32656a2e-ee50-4835-b479-aabc4396016f2011-01-04 13:57:15.461 CETdd725567-2a4d-4685-9f8c-9722acf4d2252011-03-15 17:31:44.488 CETd42fa9b2-722c-4842-b57a-d66e98a651562011-01-17 12:36:51.706 CETbf84dfe6-5cbe-488b-86e4-4a71ece58e692010-09-08 15:35:53.307 CEST5a385bf1-6932-4e41-80f9-e06dd644f32c2011-07-29 17:38:38.740 CEST40c5876a-1731-454a-8463-a1bc4746279e2011-02-09 18:32:24.812 CET7c0b2875-054e-40a4-a02e-1135e93e90842011-03-16 11:21:50.99 CET11a2dca5-f9cc-4121-ac2d-1da011bf6ad82011-01-04 16:15:49.408 CETc8575cda-c374-412c-8a5a-217362c83ffd2011-03-15 17:33:58.694 CET2fe89980-66f4-4bea-9c9e-c28ef4ea10ac2011-01-24 17:10:29.201 CET4f339317-dc4d-4151-8203-893f0e707b072011-01-07 15:23:18.432 CET88f6405e-9afb-4f26-9a78-36c60e5a4dcd2011-01-17 12:32:11.716 CETa75d9a51-eff5-406c-87e4-9b819a305c0b2011-01-04 11:19:54.815 CETb38d4ffb-21bf-4544-973d-bb152f8433122011-02-09 17:57:43.937 CET7dcbaabc-a79e-4438-8203-cfd54c97445f2011-01-21 14:43:56.580 CET7bdae3e8-a90c-434a-b7d9-a0479072e7cb2011-02-08 15:47:42.312 CET5022eb2d-6711-4b4b-97e0-8c62f9776c452011-01-07 13:03:46.867 CET658773b8-c856-4e48-a0b8-50e41be3d69d2010-12-20 15:49:39.984 CETca5a4b71-527c-4651-acb1-a99f7f6ba08a2011-02-09 18:04:27.312 CET432f00f4-ba45-4877-b237-7352e0217da02011-03-15 13:37:09.657 CETEU-ADR IMIM2010-07-19 13:20:24.541 CEST5407a926-aa31-4f07-a813-f44a9655c7342011-02-09 18:35:59.593 CETThis workflow checks if there are proteins that are annotated to a given adverse event and at the same time target of the given drug.
As adverse event, the following event types are allowed:
1) events as defined in the EU-ADR project such as UGIB
2) UMLS CUI concept identifiers
As drug input 7 digit drug ATC codes are allowed.
As result a list of intersecting proteins is provided. If this list is not empty, the drug-event pair is substantiated as signal.
Moreover, a Cytoscape graph is generated for user-friendly visualization. It contains the event, drug and their annotated proteins as well as additional information such as links to publications etc.
2011-02-08 15:51:53.365 CETf2ce956e-e544-4d6c-a04f-534d59886d872011-02-08 16:00:52.362 CET048a6d98-ed9c-4cd8-bee7-4dc5f1f46c012011-02-08 18:27:28.1 CET29997a06-3ae7-417d-802d-241052e0e37e2011-02-09 17:53:18.656 CET8c38e822-a0f2-410e-85ee-91323183e0e02011-01-24 17:15:33.722 CETa57e7167-8c78-44a8-ae42-46497cef39462011-02-08 15:55:16.626 CETee4f5456-69c2-41e9-af9d-94e919a4f01a2011-01-14 18:13:16.336 CET131d2a55-29eb-4e0b-9fbd-8a4a5d6eea272011-02-08 17:05:26.693 CET72861079-56e6-4799-8d89-c3ef3936d0e92011-02-08 15:47:24.63 CETdf58c7fa-b2a2-47e8-812d-11219ce48b552011-03-16 12:08:28.954 CET72609134-3363-4249-8add-e098746061012011-01-07 13:00:06.54 CETcba4e9b3-6dcb-4e2f-9ebe-08f42ed5bc382011-01-17 12:49:37.448 CET882c06d0-a11e-4967-a338-a8c67dfa4fb42010-08-26 19:22:46.869 CESTf5f7d39a-e76c-4988-88a4-7d9e61f3b1162011-01-04 12:59:27.437 CETb3d4faab-9dfa-45b5-a855-af8fe03235e62011-03-16 11:15:47.889 CET218c5dcc-3492-4ba4-a473-9264f389058b2011-01-17 12:43:10.315 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CETdf79c8c4-6777-48c5-9d59-00ccab13e43d2011-01-04 16:13:26.111 CETab28e2f3-9232-420a-bcf9-13bb1f774a022011-02-08 15:52:34.326 CETdd12e38a-a639-4553-8fd5-fb278a79b4442011-01-07 12:39:58.59 CET55639062-218e-41bb-839e-d2c3d4659a1c2010-08-26 17:15:56.889 CEST58bbae56-adfb-44c2-9b50-0a055c6559702011-01-17 10:38:00.451 CETd0498cc8-621b-4e2f-aa6b-87b5b47aaa462011-02-09 18:14:42.593 CET0aabc0d8-a7bb-4b9b-a8aa-6d238ce4d7db2010-08-26 19:24:05.143 CEST193d9e9b-4196-427e-8fc0-321cbd79a24a2011-02-08 15:42:42.20 CET99b09bd0-fbde-4b36-a901-ddc37b71f19d2011-03-15 15:24:00.539 CET3d05b413-9350-46d1-afae-f1db198659c72010-09-17 10:40:56.793 CEST8cd36716-c8a9-4ff0-93a9-9530dfc78bb92011-02-09 17:55:19.437 CET304ef1c5-fee1-4c6d-9d22-2b0a8b3285fc2011-01-17 12:50:25.677 CET20505947-c57b-4bd0-8ebc-6a2fd70826952011-02-08 18:02:19.99 CET5bb85af5-a496-4d13-a8e3-4dc8ed33713c2011-03-15 15:49:27.533 CET51b94baf-5dc4-4093-93ed-675f22842e6b2011-03-15 17:39:39.758 CET8e17ab19-7c07-4906-a32f-a416f706188d2010-09-08 15:34:46.474 CESTd08bc93b-51c4-4c40-bd72-11d549c32ead2011-01-13 14:06:02.321 CET86ef6f43-c15f-4c2b-940a-1a73704cbaac2011-01-10 12:49:33.152 CET21e4c0a6-9a6c-4460-9c47-127288c8b2192011-01-07 17:01:53.65 CET4b08aa99-b8dc-4318-9bf3-0cf0350ab3b22011-01-04 17:43:08.489 CETe2c37fc0-0f67-4d25-8cbb-b37672fc6f192011-01-21 14:21:30.282 CET4f80ffa7-b20d-46d2-a4dc-0c456188b0b42011-03-03 17:27:23.585 CET423144e5-b1a3-44e0-a4c7-2033e11180852011-01-07 13:14:01.754 CET4746b9ae-526f-48ab-b0c9-8db651c63d992011-03-15 15:20:36.732 CETdeb58f7d-9e66-44bb-b930-e5e49ea313cb2010-12-20 15:29:06.561 CETec258c77-f3a3-4657-9329-c820ab6870c62011-01-04 12:47:28.68 CETb96f98ce-8fe3-4eb7-b6c6-79ddbab803022011-02-09 18:34:08.875 CET234336e6-ed6f-423e-b2ab-f3329a87cb432011-03-15 14:59:32.577 CET0bff4792-0550-4275-9469-51ab7f99b75b2011-03-15 16:23:14.747 CET2c032302-7b2d-456c-8535-738147b8b8992011-02-09 17:51:57.265 CETd9173713-01e6-42cc-a1e3-cbf3ef27a6b32011-01-13 14:48:14.496 CETf6a9a5d5-7bc0-4e6a-a358-86323f82185f2011-03-15 17:26:10.456 CETc37dbf69-e5ac-451a-b579-163c7ac5d6652011-01-17 10:32:32.30 CET41db8492-1074-4db3-a1f7-91f6e570c1e82011-02-08 18:28:32.994 CET