Content from the VLe group

Affimetrix microarray: part two (perm) (1)

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We use a permutation test to infer the significance of the differently expressed genes found by the ANOVA analysis. Permutation tests are computationally intensive, needing at least 1000 permutations per gene to obtain acceptable results. For large experiments, the in-built feature of running R/MAANOVA in a single cluster may not be enough. We are using WS- VLAM workflow management system [2] to create a Grid-enabled R/MAANOVA workflow (Grid-MAANOVA) that will simultaneously run in multiple c...

Created: 2008-12-05

Credits: Zhiming Zhao

Affimetrix microarray: part three (concat) (1)

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Collecting the results from the perumtation.

Created: 2008-12-05

Credits: Zhiming Zhao

Affimetrix microarray: part one (obs) (1)

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The R/MAANOVA package [1] is being adapted to carry out our computations. To enable R/MAANOVA to handle probe-sets with different probe numbers, which is necessary when using probe-set definitions other than the original one provided by Affimetrix, we will pre-process the input data by dividing it into groups, each group formed by genes reported by the same number of probes.

Created: 2008-12-05

Credits: Zhiming Zhao