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Drkrish...

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STUDY OF QUANTIFICATION OF IMPURITIES AND RELATED SU...

Created: 2012-08-13 16:46:39

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Bulk drug during its production process, after its scale up, it is necessary to analyse for the presence of any impurities or related substances in it. This is to ensure the impurities and related substances are within their limits as per ICH Guidelines. The impurities and related substances are defined as; Impurity: Any component present in the drug substance or drug product which is not the desired product, a product-related substance, or excipient including buffer com...

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Khalid Belhajjame

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Execution traces copied from the vistrails console ...

Created: 2012-08-06 11:00:38

Credits: Khalid Belhajjame

License: Creative Commons Attribution-Share Alike 3.0 Unported License

This is the execution trace as it appeared in the Vistrailsworkbench of the workflow that retrieves the pathways associated with given kegg gene identifier.

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Khalid Belhajjame

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Provenance traces of the Gene To Pathway Taverna Wor...

Created: 2012-08-06 10:58:38

Credits: Khalid Belhajjame

License: Creative Commons Attribution-Share Alike 3.0 Unported License

This is the provenance trace in Janus of the Tavrerna workflow that retrieves the pathways associated with given kegg gene identifier.

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Khalid Belhajjame

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Provenance traces of the Gene To Pathway Taverna Wor...

Created: 2012-08-06 10:57:37

Credits: Khalid Belhajjame

License: Creative Commons Attribution-Share Alike 3.0 Unported License

This is the provenance trace in provo of the Tavrerna workflow that retrieves the pathways associated with given kegg gene identifier.

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Program...

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Combined workflow from my master work

Created: 2012-08-03 11:13:35

Credits: Programmerva

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Here is two workflows is combined to one workflow. One part of this workflows is taken from MyExperiment.

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Cherian Mathew

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Data Refinement Workflow Utility Jar (Current Version)

Created: 2012-07-26 14:56:42 | Last updated: 2012-11-07 08:48:49

Credits: Cherian Mathew

License: Creative Commons Attribution-Share Alike 3.0 Unported License

jar which includes all utility classes with functionality used in the Data Refeinement workflow

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Drkrish...

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Process for the preparation of amorphous atorvastati...

Created: 2012-07-24 12:07:03

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Atorvastatin calcium is a drug compound that is used as a lipid-lowering agent, fortreating hypercholesterolemia. The compound has the chemical name[R-(R*,R*)]-2-(4-fluorophenyl)-3,ö-dihydroxy-5-(1-methylethyl)-3-phenyl-4-{(phenylamino)carbonyl}-1H-pyrolle-1-hepatonic acid, calcium salt (2:1) trihydrate. Pharmaceutical productscontaining crystalline atorvastatin calcium trihydrate are sold using the trademarkLIPITOR.

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Drkrish...

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Novel polymorph of 5-cyanopthalide high purity inter...

Created: 2012-07-24 12:02:16

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

The present invention relates to obtaining a new polymorph of 5-Cyanophthalide in highly pure form (99.5 to 99.99%), which is an intermediate used forthe synthesis of citalopram& escitalopram both of which are potent antidepressant drugs.Moreover this new polymorph of 5-cyanophthalide does not contain impurities liketerephthalic acid & diphthalide derivatives.

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Drkrish...

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Enantioselective method of synthesizing methylphenid...

Created: 2012-07-24 11:51:52

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Process for the preparation of enantioselective method of making methylphenidate and derivatives . The method involves use of a rhodium catalyst, and selectively produces the D-enantiomer of the methylphenidate derivative in excess of the L-enantiomer . Furthermore, the method selectively produces the threo-diastereomer in excess of the erythro-diastereomer. The method is thus suitable for synthesis of D-threo-methylphenidate (the biologically active form of this compound) and derivatives &...

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Drkrish...

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Quality Assurance and GMP and ICH

Created: 2012-07-24 11:46:03

Credits: Drkrishnasarmapathy

License: Creative Commons Attribution-Share Alike 3.0 Unported License

Quality Assurance is a planned and systematic approach to generate enough confidence in the quality of the product and processes in the long run as per the specifications." In this biog you will find post related to ICH, GMP and Quality related matters.

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