ID 1A29_HUMAN Reviewed; 365 AA. AC P30512; O02955; O19687; O98011; P30451; P79562; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 15-JUL-1998, sequence version 2. DT 22-JUL-2008, entry version 78. DE RecName: Full=HLA class I histocompatibility antigen, A-29 alpha chain; DE AltName: Full=MHC class I antigen A*29; DE AltName: Full=Aw-19; DE Flags: Precursor; GN Name=HLA-A; Synonyms=HLAA; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*2901). RX MEDLINE=89065816; PubMed=2461903; DOI=10.1007/BF02341610; RA Trapani J.A., Mizuno S., Kang S.H., Yang S.Y., Dupont B.; RT "Molecular mapping of a new public HLA class I epitope shared by all RT HLA-B and HLA-C antigens and defined by a monoclonal antibody."; RL Immunogenetics 29:25-32(1989). RN [2] RP SEQUENCE REVISION TO 345. RA Yang S.Y.; RL Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE (ALLELE A*2901). RA Szmania S., Baxter-Lowe L.A.; RL Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*2902). RX MEDLINE=92145462; PubMed=1782566; RA Tabary T., Prochnicka-Chalufour A., Cornillet P., Lehoang P., RA Betuel H., Cohen H.M.; RT "HLA-A29 sub-types and 'Birdshot' choroido-retinopathy susceptibility: RT a possible 'resistance motif' in the HLA-A29.1 molecule."; RL C. R. Acad. Sci. III, Sci. Vie 313:599-605(1991). RN [5] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ALLELE A*2903). RX MEDLINE=98119601; PubMed=9459513; RA Prokupek B., Dunn P., Ross J., Jordan F., Holman R., Madrigal J.A., RA Little A.-M.; RT "HLA-A*2903 expresses an epitope shared with HLA-A*8001."; RL Tissue Antigens 51:115-118(1998). RN [6] RP NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*2904). RX MEDLINE=21160440; PubMed=11260503; RX DOI=10.1034/j.1399-0039.2001.057002095.x; RA Hickman H.D., Cavett J.W., Ellexson-Turner M.E., Sparkman J.N., RA Bennett T.T., Turner S., Sidebottom D.A., Trachtenberg E.A., RA Confer D.L., Hildebrand W.H.; RT "Non-conservative substitutions distinguish previously uncharacterized RT HLA-A molecules."; RL Tissue Antigens 57:95-102(2001). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- CC microglobulin). Interacts with human herpesvirus 8 MIR1 protein CC (By similarity). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- PTM: Polyubiquitinated in a post ER compartment by interaction CC with human herpesvirus 8 MIR1 protein. This targets the protein CC for rapid degradation via the ubiquitin system (By similarity). CC -!- POLYMORPHISM: The following alleles of A-29 are known: A*2901 CC (A29.1), A*2902 (A29.2), A*2903 and A*2904. The sequence shown is CC that of A*2901. CC -!- SIMILARITY: Belongs to the MHC class I family. CC -!- SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like) CC domain. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; M23739; AAB47873.1; -; mRNA. DR EMBL; U83415; AAB53373.1; -; mRNA. DR EMBL; X60108; CAA42702.1; -; mRNA. DR EMBL; AJ000661; CAA04209.1; -; mRNA. DR EMBL; Y09218; CAA70419.1; -; Genomic_DNA. DR EMBL; AF042189; AAD02224.1; -; Genomic_DNA. DR EMBL; AF042188; AAD02224.1; JOINED; Genomic_DNA. DR PIR; A45847; A45847. DR RefSeq; NP_001074309.1; -. DR UniGene; Hs.181244; -. DR UniGene; Hs.652059; -. DR HSSP; P10315; 1HSB. DR SMR; P30512; 25-299. DR Ensembl; ENSG00000206505; Homo sapiens. DR GeneID; 649853; -. DR KEGG; hsa:649853; -. DR HGNC; HGNC:4931; HLA-A. DR MIM; 142800; gene. DR PharmGKB; PA35055; -. DR HOVERGEN; P30512; -. DR CleanEx; HS_HLA-A; -. DR GermOnline; ENSG00000204632; Homo sapiens. DR InterPro; IPR007110; Ig-like. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1. DR Gene3D; G3DSA:3.30.500.10; MHC_I-like_Ag-recog; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR ProDom; PD000050; MHC_I; 1. DR SMART; SM00407; IGc1; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Glycoprotein; Host-virus interaction; Immune response; Membrane; KW MHC I; Polymorphism; Signal; Transmembrane; Ubl conjugation. FT SIGNAL 1 24 FT CHAIN 25 365 HLA class I histocompatibility antigen, FT A-29 alpha chain. FT /FTId=PRO_0000018821. FT TOPO_DOM 25 308 Extracellular (Potential). FT TRANSMEM 309 332 Potential. FT TOPO_DOM 333 365 Cytoplasmic (Potential). FT DOMAIN 209 295 Ig-like C1-type. FT REGION 25 114 Alpha-1. FT REGION 115 206 Alpha-2. FT REGION 207 298 Alpha-3. FT REGION 299 308 Connecting peptide. FT CARBOHYD 110 110 N-linked (GlcNAc...) (By similarity). FT DISULFID 125 188 By similarity. FT DISULFID 227 283 By similarity. FT VARIANT 90 90 N -> H (in allele A*2904). FT /FTId=VAR_016347. FT VARIANT 126 126 H -> D (in allele A*2902, allele A*2903 FT and allele A*2904). FT /FTId=VAR_004365. FT VARIANT 190 191 EW -> DG (in allele A*2903). FT /FTId=VAR_010372. SQ SEQUENCE 365 AA; 40863 MW; 56E4B9039B3C783C CRC64; MAVMAPRTLL LLLLGALALT QTWAGSHSMR YFTTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDLQTRN VKAQSQTDRA NLGTLRGYYN QSEAGSHTIQ MMYGCHVGSD GRFLRGYRQD AYDGKDYIAL NEDLRSWTAA DMAAQITQRK WEAARVAEQL RAYLEGTCVE WLRRYLENGK ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAS VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP SSQPTIPIVG IIAGLVLFGA VFAGAVVAAV RWRRKSSDRK GGSYSQAASS DSAQGSDMSL TACKV //