BioAID_EnirchBioModelWithProteinsFromText

Created: 2009-05-16 01:06:26 Last updated: 2009-05-16 01:13:18

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This workflow extracts proteins and protein relations from Medline. Extracted protein names (symbols of at least 3 characters) are validated against mouse, rat, and human UniProt symbols, so the results are limited to these species.

This workflow follows the following basic steps:

it retrieves documents relevant for the query string
it discovers proteins in those documents, considered relevant to the query string (colocation in text mining terms)
it extract protein-protein relations (slightly stronger than colocation)

In addition, the results are added to a biological model to support hypthesis formation and a procedural model to log trails to evidence. The models are based on description logic (RDF/OWL format).

Acknowledgements:

Synonyms and Uniprot services: Martijn Scheumie, BioSemantics Group, University of Rotterdam, The Netherlands (BioRange project)

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Workflow Components

Inputs (3)

Name	Description
query	Biological query, e.g. a protein of interest. See Lucene documentation for advanced queries (http://lucene.apache.org/) Synonyms for protein names will be searched and added for terms within double quotes.
max_document_nr	limits the maximum number of hits search will produce. In Taverna 1 '100' works well while a 1000 and above is likely to halt Taverna 1 due to memory problems. This also depends on the memory setting for the java virtual machine by the client (usually your local Taverna).
aida_magic_word	A magic word is required to make use of the AIDA semantic repository for BioAID workflows. Please ask Scott Marshall (marshall@science.uva.nl) or Marco Roos (M.Roos1@uva.nl) for the magic word. NB: this semantic repository is for temporary data only. You should expect the repository to be cleared often and without warning.

Processors (18)

Name	Type	Description
false	stringconstant
Timestamp	beanshell
true	stringconstant
s07_AddScoreToSemanticModel	workflow	Add RDF cf: @prefix mybio: <http://rdf.adaptivedisclosure.org/owl/BioAID/myModel/Proto-ontology/BiologicalModel.owl#> . @prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> . @prefix pub: <http://rdf.adaptivedisclosure.org/owl/BioAID/myModel/Proto-ontology/Publication.owl#> . @prefix dsc: <http://rdf.adaptivedisclosure.org/owl/BioAID/myModel/Enriched-ontology/DiscoveredEntities.owl#> . @prefix owl: <http://www.w3.org/2002/07/owl#> . @prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> . <http://rdf.adaptivedisclosure.org/owl/BioAID/myModel/Enriched-ontology/BiologicalDiscoveries.owl#ExampleInstance_DiscoveredEnzyme> a <http://rdf.adaptivedisclosure.org/owl/BioAID/myModel/Enriched-ontology/BiologicalDiscoveries.owl#DiscoveredEnzyme> ; dsc:hasLikelihoodScore "1.0"^^<http://www.w3.org/2001/XMLSchema#float> .
s06_AddProteinRelationToSemanticModel	workflow
06_UniProtXrefURLs	workflow	Adds URL cross references to various protein information resources.
s01_AddBiologicalModelToSemanticModel	workflow	Add Query to Semantic model with Sesame service cf example Biological Query
s03_AddExpandedQueryToSemanticModel_Obsolete	workflow	Add Query to Semantic model with Sesame service cf example Biological Query
s05_AddProteinToSemanticModel	workflow	Add Protein to Semantic model with Sesame service cf example Discovered Proteins
02_RetrieveDocumentsFromMedline	workflow	This workflow applies the search web service from the AIDA toolbox. Comments: This search service is based on lucene defaults; it may be necessary to optimize the querystring to adopt the behaviour to what is most relevant in a particular domain (e.g. for medline prioritizing based on publication date is useful). Lucene favours shorter sentences, which may be bad for subsequent information extraction.
s03_AddExpandedQueryToSemanticModel	workflow	Add autamotically expanded query to Semantic model.
s02_AddOriginalQueryToSemanticModel	workflow	Add Query to Semantic model with Sesame service cf example Biological Query
05_ScoreExtractedProteins	workflow	This workflow calculates a min log likelihood score for the combination of a discoverd protein and a protein of interest (the query protein). Note that at the moment the total count of medline papers, which is part of the formula, is hard coded and not exact. Given its size this should not matter that much, and certainly not in comparison with other likelihoods calculated using the same value.
04_ExtractProteinRelations_HomoSapiens	workflow	Workflow to extract protein protein interactions from text, followed by filtering protein names known as human protein names. The protein protein interaction service takes the output in 'IOB' format from applyCRF, which annotates proteins as such in text.
01_ProcessQuery	workflow	Workflow to optimize a Lucene document retrieval query to 1. increase the priority of recent years (in decreasing order from 2009 down to 2002) 2. limit a subsequent search to a specific organism using a mesh organism tag
s04_AddDocToSemanticModel	workflow	Add Document to Semantic model with Sesame service cf example discovered document
03_ExtractProteins_HomoSapiens	workflow	Workflow to extract proteins from text, followed by filtering protein names known as human protein names.
s00_InitializeSemanticStorage	workflow

Beanshells (59)

Name	Inputs	Outputs
InstantiateSemanticType	instance_ontology_url instance_name type_uri label_string comment_string	NTriple_InstanceOf_statement instance_uri
ReplaceCharsForID	input	output
NTriple_AnnotationsOfInstance_statement	instance_uri label_string comment_string	NTriple_LabelCommentOfInstance_statement
NTriple_QueryRelation_stmnt	domain_instance_uri range_instance_uri relation_ontology_url relation_name	NTriple_Relation_statement
SlashDoubleQuotes	input findstring replacestring	output
NTriple_QueryPropertyOfInstance_statement	instance_uri property_ontology_url property_name property_string	NTriple_PropertyOfInstance_statement property_uri
ConcatenateRDFdoc	NTripleInstanceStatement NTripleAnnotationsStatement NTriplePropertyStatement NTripleRelationStatement	RDFdoc
ReplaceCharsForQueryID	input	output
NTriple_InstanceOf_statement	instance_ontology_url type_ontology_url instance_name type_name	instance_uri NTriple_InstanceOf_statement
DefineSemanticRelation_hasParticipant	domain_instance_uri relation_uri range_instance_uri	NTriple_Relation_statement
DefineSemanticRelation_discovered_by	domain_instance_uri relation_uri range_instance_uri	NTriple_Relation_statement
DefineSemanticRelation_references	domain_instance_uri relation_uri range_instance_uri	NTriple_Relation_statement
InstantiateSemanticType_Protein	instance_ontology_url instance_name type_uri label_string comment_string datetime	NTriple_InstanceOf_statement instance_uri
InstantiateSemanticType_ProteinTerm	instance_ontology_url instance_name type_uri label_string comment_string datetime	NTriple_InstanceOf_statement instance_uri
ProteinTermAnnotations	protein_name uniprot_id	protein_label protein_comment protein_term_label protein_term_comment
ConcatenateStringList	stringlist delimiter	output
InstantiateQueryInstance	instance_ontology_url instance_name type_uri label_string comment_string datetime	NTriple_InstanceOf_statement instance_uri
ReplaceCharsForQueryID	input	output
DefineSemanticRelation_expansion_of	domain_instance_uri relation_uri range_instance_uri	NTriple_Relation_statement
DefineBooleanPropertyOfInstance	instance_uri property_uri property_string	NTriple_PropertyOfInstance_statement
ConcatenateRDFstatements	stringlist delimiter	output
DefinePropertyOfInstance	property_uri property_string instance_uri	NTriple_PropertyOfInstance_statement
DefineSemanticRelation_references	domain_instance_uri relation_uri range_instance_uri	NTriple_Relation_statement
SlashDoubleQuotes	input findstring replacestring	output
DefineSemanticRelation	domain_instance_uri relation_uri range_instance_uri	NTriple_Relation_statement
DefinePropertyOfInstance	property_uri property_string instance_uri	NTriple_PropertyOfInstance_statement
ConcatenateRDFstatements	stringlist delimiter	output
ReplaceCharsForQueryID	input	output
InstantiateQueryInstance	instance_ontology_url instance_name type_uri label_string comment_string datetime	NTriple_InstanceOf_statement instance_uri
SlashDoubleQuotes	input findstring replacestring	output
DefineBooleanPropertyOfInstance	instance_uri property_uri property_string	NTriple_PropertyOfInstance_statement
RelativeFrequencyPoiInCorpus	corpus_total poi_count_in_corpus	relative_frequency
RelativeFrequencyPoiInCorpus	corpus_total poi_count_in_corpus	relative_frequency
PoiAndDpQuery	poi_query dp_query	poi_and_dp_query
CountListElements	list	count
CloneQueries	copy_number input	clones
MinLogLikelihood	query_frequency discovered_frequency query_discovered_frequency total_frequency	minloglikelihood
CloneFrequencies	copy_number input	clones
UniProtOrNot2	uniprotIDlist	uniprotID_or_False
UniProtOrNot1	uniprotIDlist	uniprotID_or_False
FilterTrueProteinPairsByUniProtID	protein1 uniprot1 protein2 uniprot2	true_protein1 true_uniprot1 true_protein2 true_uniprot2
example_interaction_doc		interaction_doc
ConcatenateRelation	protein_name1 protein_name2 interaction_term uniprot_id1 uniprot_id2	relation id_relation
FilterTrueProteinByUniProtID	protein uniprot	true_protein true_uniprot
UniProtOrNot	uniprotIDlist	uniprotID_or_False
ReplaceLuceneTokenByOriginalTerm	query_string tokenlist	output_list
Concat_synonyms	synonymlist query_term	new_query
ListFindAndReplace	input findstringlist replacestringlist	output
Prioritise_lucene_query	query_string priority_string	lucene_query
InstantiateSemanticType	instance_ontology_url instance_name type_uri label_string comment_string datetime	NTriple_InstanceOf_statement instance_uri
DefineSemanticRelation_has_output	domain_instance_uri relation_uri range_instance_uri	NTriple_Relation_statement
DefineSemanticRelation_discovered_by	domain_instance_uri relation_uri range_instance_uri	NTriple_Relation_statement
NTriple_WorkflowRelation_stmnt	domain_instance_uri relation_uri range_instance_uri	NTriple_Relation_statement
ConcatenateStringList	stringlist delimiter	output
UniProtOrNot	uniprotIDlist	uniprotID_or_False
FilterTrueProteinByUniProtID	protein uniprot	true_protein true_uniprot
Strip_xml	tagged_term	term
RepositoryRef	sesame_url repository	bioaid_repository_url
Timestamp		now_RFC822 now_short now_ISO8601

Outputs (7)

Name	Description
ProteinURL
PubMed_URL
protein_discovery_score
Protein_name
Relation
RDFtriples_doc_url
BioAID_RDFrepository_URL

Links (63)

Source	Sink
aida_magic_word	s00_InitializeSemanticStorage:aida_magic_word
max_document_nr	02_RetrieveDocumentsFromMedline:maxHits
query	01_ProcessQuery:query_string
01_ProcessQuery:extended_lucene_query	02_RetrieveDocumentsFromMedline:queryString
01_ProcessQuery:extended_lucene_query	05_ScoreExtractedProteins:query
01_ProcessQuery:extended_lucene_query	s03_AddExpandedQueryToSemanticModel:query
01_ProcessQuery:extended_lucene_query	s03_AddExpandedQueryToSemanticModel_Obsolete:expanded_query
02_RetrieveDocumentsFromMedline:abstract	03_ExtractProteins_HomoSapiens:input_text
02_RetrieveDocumentsFromMedline:abstract	04_ExtractProteinRelations_HomoSapiens:input_text
02_RetrieveDocumentsFromMedline:pubmed_URL	s04_AddDocToSemanticModel:pubmed_URL
02_RetrieveDocumentsFromMedline:pubmed_id	s04_AddDocToSemanticModel:pubmed_id
03_ExtractProteins_HomoSapiens:protein_name	05_ScoreExtractedProteins:discovered_protein
03_ExtractProteins_HomoSapiens:protein_name	s05_AddProteinToSemanticModel:protein_name
03_ExtractProteins_HomoSapiens:uniprotID	06_UniProtXrefURLs:UniProtID
03_ExtractProteins_HomoSapiens:uniprotID	s05_AddProteinToSemanticModel:uniprot_id
04_ExtractProteinRelations_HomoSapiens:relation_term	s06_AddProteinRelationToSemanticModel:interaction_term
04_ExtractProteinRelations_HomoSapiens:uniprot_id1	s06_AddProteinRelationToSemanticModel:uniprot_id1
04_ExtractProteinRelations_HomoSapiens:uniprot_id2	s06_AddProteinRelationToSemanticModel:uniprot_id2
05_ScoreExtractedProteins:min_log_likelihood	s07_AddScoreToSemanticModel:score
05_ScoreExtractedProteins:min_log_likelihood	s07_AddScoreToSemanticModel:score
06_UniProtXrefURLs:EntrezUniProtURL	s05_AddProteinToSemanticModel:entrez_pubmed_URL
06_UniProtXrefURLs:ExpasyUniProtURL	s05_AddProteinToSemanticModel:expasy_URL
06_UniProtXrefURLs:iHopSearchURL	s05_AddProteinToSemanticModel:iHop_search_URL
06_UniProtXrefURLs:iHopSentencesURL	s05_AddProteinToSemanticModel:iHop_sentence_URL
Timestamp:now_ISO8601	s03_AddExpandedQueryToSemanticModel:datetime
Timestamp:now_ISO8601	s04_AddDocToSemanticModel:datetime
Timestamp:now_ISO8601	s05_AddProteinToSemanticModel:datetime
false:value	s00_InitializeSemanticStorage:do_not_add_to_repository
false:value	s00_InitializeSemanticStorage:do_not_clear_repository
false:value	s00_InitializeSemanticStorage:do_not_clear_tmp_rdf_file
query	s01_AddBiologicalModelToSemanticModel:BioModelComment
query	s01_AddBiologicalModelToSemanticModel:ModelIdentifyingName
query	s02_AddOriginalQueryToSemanticModel:query
04_ExtractProteinRelations_HomoSapiens:protein1	s06_AddProteinRelationToSemanticModel:protein_name1
s00_InitializeSemanticStorage:BioAIDinstances_ontology_url	s01_AddBiologicalModelToSemanticModel:InstanceOntologyURL
s00_InitializeSemanticStorage:BioAIDinstances_ontology_url	s02_AddOriginalQueryToSemanticModel:InstanceOntologyURL
s00_InitializeSemanticStorage:BioAIDinstances_ontology_url	s03_AddExpandedQueryToSemanticModel_Obsolete:InstanceOntologyURL
s00_InitializeSemanticStorage:BioAIDinstances_ontology_url	s04_AddDocToSemanticModel:instance_ontology_url
s00_InitializeSemanticStorage:RDFoutput_doc_url	s02_AddOriginalQueryToSemanticModel:RDF_doc_filename
s00_InitializeSemanticStorage:RDFoutput_doc_url	s03_AddExpandedQueryToSemanticModel_Obsolete:RDF_doc_filename
s00_InitializeSemanticStorage:RDFoutput_doc_url	s04_AddDocToSemanticModel:rdf_output_doc_url
s00_InitializeSemanticStorage:TextMining_ontology_url	s03_AddExpandedQueryToSemanticModel_Obsolete:TextMiningOntologyURL
s02_AddOriginalQueryToSemanticModel:query_instance	s03_AddExpandedQueryToSemanticModel_Obsolete:original_query_instance_uri
02_RetrieveDocumentsFromMedline:pubmed_URL	PubMed_URL
03_ExtractProteins_HomoSapiens:protein_name	Protein_name
04_ExtractProteinRelations_HomoSapiens:protein2	s06_AddProteinRelationToSemanticModel:protein_name2
04_ExtractProteinRelations_HomoSapiens:relation	Relation
05_ScoreExtractedProteins:min_log_likelihood	protein_discovery_score
06_UniProtXrefURLs:EntrezUniProtURL	ProteinURL
Timestamp:now_ISO8601	s02_AddOriginalQueryToSemanticModel:datetime
s00_InitializeSemanticStorage:BioAID_Repository_url	BioAID_RDFrepository_URL
s00_InitializeSemanticStorage:BioAIDinstances_ontology_url	s03_AddExpandedQueryToSemanticModel:InstanceOntologyURL
s00_InitializeSemanticStorage:BioAIDinstances_ontology_url	s05_AddProteinToSemanticModel:instance_ontology_url
s00_InitializeSemanticStorage:RDFoutput_doc_url	s01_AddBiologicalModelToSemanticModel:RDF_doc_filename
s00_InitializeSemanticStorage:RDFoutput_doc_url	s03_AddExpandedQueryToSemanticModel:RDF_doc_filename
s00_InitializeSemanticStorage:RDFoutput_doc_url	s05_AddProteinToSemanticModel:tmp_rdf_output_fileref
s01_AddBiologicalModelToSemanticModel:biomodel_instance_uri	s02_AddOriginalQueryToSemanticModel:model_instance_uri
s01_AddBiologicalModelToSemanticModel:biomodel_instance_uri	s03_AddExpandedQueryToSemanticModel:model_instance_uri
s01_AddBiologicalModelToSemanticModel:biomodel_instance_uri	s05_AddProteinToSemanticModel:model_instance_uri
s02_AddOriginalQueryToSemanticModel:query_instance	s03_AddExpandedQueryToSemanticModel:original_query_instance_uri
s03_AddExpandedQueryToSemanticModel_Obsolete:QueryRDFdoc_url	RDFtriples_doc_url
s04_AddDocToSemanticModel:doc_instance_uri	s05_AddProteinToSemanticModel:doc_instance_uri
s05_AddProteinToSemanticModel:protein_instance	s07_AddScoreToSemanticModel:protein_instance

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Taverna 1

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Marco Roos

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Information Statistics

7694 viewings

2591 downloads

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Version History

In chronological order:

BioAID_ProteinDiscovery_HomoSapiens

Created by Marco Roos on Friday 22 August 2008 11:00:29 (UTC)

Last edited by Marco Roos on Tuesday 26 August 2008 15:56:58 (UTC)
BioAID_EnirchBioModelWithProteinsFromText

Created by Marco Roos on Friday 22 August 2008 11:00:29 (UTC)

Last edited by Marco Roos on Tuesday 26 August 2008 16:05:11 (UTC)

Revision comment:

Protein discovery workflow that stores instances in a semantic model that separates biology (intensional) knowledge from procedural (extensional) knowledge.
Semantic types in the semantic sub workflows are obtained provisionally using strings produced by a workflow (GetFromSesame.xml) that gets types from a Sesame repository containing the template ontologies.
BioAID_EnirchBioModelWithProteinsFromText

Created by Marco Roos on Friday 22 August 2008 11:00:29 (UTC)

Last edited by Marco Roos on Wednesday 27 August 2008 23:15:01 (UTC)

Revision comment:

Minor update. Changed the description.
BioAID_EnirchBioModelWithProteinsFromText

Created by Marco Roos on Wednesday 29 October 2008 09:14:51 (UTC)

Revision comment:

Adjustments for semantic model updates.
BioAID_EnirchBioModelWithProteinsFromText

Created by Marco Roos on Wednesday 29 October 2008 09:27:18 (UTC)

Last edited by Marco Roos on Friday 15 May 2009 16:38:18 (UTC)

Revision comment:

Minor updates to get the syncing of document instances and proteins right.
BioAID_EnirchBioModelWithProteinsFromText
Created by Marco Roos on Saturday 16 May 2009 00:57:14 (UTC)

Revision comment:
- Temporary switch to development server because of minor unresolved issues with production server
- Changed location of SynSets service.
BioAID_EnirchBioModelWithProteinsFromText
Created by Marco Roos on Saturday 16 May 2009 01:06:26 (UTC)

Last edited by Marco Roos on Saturday 16 May 2009 01:13:19 (UTC)

Revision comment:
1. Temporary return to aida development server due to minor issues with production server
2. Changed URL of SynSets service (it moved)

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Marco Roos	Friday 27 November 2009 11:43:02 (UTC)
	This workflow may need some work because of a recent server migration... Our apologies.

Other workflows that use similar services (1)

Taverna 1

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Marco Roos

BioAID_ProteinDiscovery_filterOnHumanUnipr... (11)

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This workflow finds proteins relevant to the query string via the following steps: A user query: a single gene/protein name. E.g.: (EZH2 OR "Enhancer of Zeste"). Retrieve documents: finds 'maximumNumberOfHits' relevant documents (abstract+title) based on query (the AIDA service inside is based on Apache's Lucene) Discover proteins: extract proteins discovered in the set of relevant abstracts with a 'named entity recognizer' trained on genomic terms using a Bayesian approach; the AIDA serv...

Created: 2009-05-28

Credits: Marco Roos Martijn Schuemie AID AID_myGrid_collaboration

Attributions: BioAID_DiseaseDiscovery_RatHumanMouseUniprotFilter